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Mansoor, Sana,Maheshwari, Anshu,Guglielmo, Matthew Di,Furuya, Katryn,Wang, Makala,Crowgey, Erin,Molle-Rios, Zarela,He, Zhaoping The Korean Society of Pediatric Gastroenterology 2021 Pediatric gastroenterology, hepatology & nutrition Vol.24 No.5
Purpose: The rs641738 C>T in membrane-bound O-acyltransferase domain-containing protein 7 (MBOAT7) is implicated, along with the rs738409 C>G polymorphism in patatin-like phospholipase domain-containing protein 3 (PNPLA3), in nonalcoholic fatty liver disease (NAFLD). The association of these polymorphisms and NAFLD are investigated in Hispanic children with obesity. Methods: Obese children with and without NAFLD were enrolled at a pediatric tertiary care health system and genotyped for MBOAT7 rs641738 C>T and PNPLA3 rs738409 C>G. NAFLD was characterized by the ultrasonographic presence of hepatic steatosis along with persistently elevated liver enzymes. Genetic variants and demographic and biochemical data were analyzed for the effects on NAFLD. Results: Among 126 enrolled subjects, 84 in the case group had NAFLD and 42 in the control group did not. The two groups had similar demographic distribution. NAFLD was associated with abnormal liver enzymes and elevated triglycerides and cholesterol (p<0.05). Children with NAFLD had higher percentage of PNPLA3 GG genotype at 70.2% versus 31.0% in non-NAFLD, and lower MBOAT7 TT genotype at 4.8% versus 16.7% in non-NAFLD (p<0.05). PNPLA3 rs738409 C>G had an additive effect in NAFLD; however, MBOAT7 rs641738 C>T had no effects alone or synergistically with PNPLA3 polymorphism. NAFLD risk increased 3.7-fold in subjects carrying PNPLA3 GG genotype and decreased in MBOAT7 TT genotype. Conclusion: In Hispanic children with obesity, PNPLA3 rs738409 C>G polymorphism increased the risk for NAFLD. The role of MBOAT7 rs641738 variant in NAFLD is less evident.
Virmani, Richa,Sajid, Andaleeb,Singhal, Anshika,Gaur, Mohita,Joshi, Jayadev,Bothra, Ankur,Garg, Richa,Misra, Richa,Singh, Vijay Pal,Molle, Virginie,Goel, Ajay K.,Singh, Archana,Kalia, Vipin C.,Lee, Ju American Society for Biochemistry and Molecular Bi 2019 The Journal of biological chemistry Vol.294 No.22
<P><I>Bacillus anthracis</I> is the causative agent of anthrax in humans, bovine, and other animals. <I>B. anthracis</I> pathogenesis requires differentiation of dormant spores into vegetative cells. The spores inherit cellular components as phenotypic memory from the parent cell, and this memory plays a critical role in facilitating the spores' revival. Because metabolism initiates at the beginning of spore germination, here we metabolically reprogrammed <I>B. anthracis</I> cells to understand the role of glycolytic enzymes in this process. We show that increased expression of enolase (Eno) in the sporulating mother cell decreases germination efficiency. Eno is phosphorylated by the conserved Ser/Thr protein kinase PrkC which decreases the catalytic activity of Eno. We found that phosphorylation also regulates Eno expression and localization, thereby controlling the overall spore germination process. Using MS analysis, we identified the sites of phosphorylation in Eno, and substitution(s) of selected phosphorylation sites helped establish the functional correlation between phosphorylation and Eno activity. We propose that PrkC-mediated regulation of Eno may help sporulating <I>B. anthracis</I> cells in adapting to nutrient deprivation. In summary, to the best of our knowledge, our study provides the first evidence that in sporulating <I>B. anthracis</I>, PrkC imprints phenotypic memory that facilitates the germination process.</P>
Moll, Jochen,Torres-Arredondo, Miguel Angel,Fritzen, Claus-Peter Techno-Press 2012 Smart Structures and Systems, An International Jou Vol.10 No.3
Guided waves have shown a great potential for structural health monitoring (SHM) applications. In contrast to traditional non-destructive testing (NDT) methodologies, a key element of SHM approaches is the high process of automation. The monitoring system should decide autonomously whether the host structure is intact or not. A basic requirement for the realization of such a system is that the sensors are permanently installed on the host structure. Thus, baseline measurements become available that can be used for diagnostic purposes, i.e., damage detection, localization, etc. This paper contributes to guided wave-based inspection in anisotropic materials for SHM purposes. Therefore, computational strategies are described for both, the solution of the complex equations for wave propagation analysis in composite materials based on exact elasticity theory and the popular global matrix method, as well as the underlying equations of two active damage localization algorithms for anisotropic structures. The result of the global matrix method is an angular and frequency dependent wave velocity characteristic that is used subsequently in the localization procedures. Numerical simulations and experimental investigations through time-delay measurements are carried out in order to validate the proposed theoretical model. An exemplary case study including the calculation of dispersion curves and damage localization is conducted on an exemplary unidirectional composite structure where the ultrasonic signals processed in the localization step are simulated with the spectral element method. The proposed study demonstrates the capabilities of the proposed algorithms for accurate damage localization in anisotropic structures.
Jochen Moll,Miguel Angel Torres-Arredondo,Claus-Peter Fritzen 국제구조공학회 2012 Smart Structures and Systems, An International Jou Vol.10 No.3
Guided waves have shown a great potential for structural health monitoring (SHM) applications. In contrast to traditional non-destructive testing (NDT) methodologies, a key element of SHM approaches is the high process of automation. The monitoring system should decide autonomously whether the host structure is intact or not. A basic requirement for the realization of such a system is that the sensors are permanently installed on the host structure. Thus, baseline measurements become available that can be used for diagnostic purposes, i.e., damage detection, localization, etc. This paper contributes to guided wave-based inspection in anisotropic materials for SHM purposes. Therefore, computational strategies are described for both, the solution of the complex equations for wave propagation analysis in composite materials based on exact elasticity theory and the popular global matrix method, as well as the underlying equations of two active damage localization algorithms for anisotropic structures. The result of the global matrix method is an angular and frequency dependent wave velocity characteristic that is used subsequently in the localization procedures. Numerical simulations and experimental investigations through time-delay measurements are carried out in order to validate the proposed theoretical model. An exemplary case study including the calculation of dispersion curves and damage localization is conducted on an exemplary unidirectional composite structure where the ultrasonic signals processed in the localization step are simulated with the spectral element method. The proposed study demonstrates the capabilities of the proposed algorithms for accurate damage localization in anisotropic structures.
Seo, Myungeun,Moll, David,Silvis, Craig,Roy, Abhishek,Querelle, Sarah,Hillmyer, Marc A. American Chemical Society 2014 INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH - Vol.53 No.48
<P>Interfacial polymerization of an acid chloride-containing block polymer and a multivalent amine in the presence of a macroporous support was explored as a means to generate a nanoporous thin film composite (TFC) membrane potentially useful for ultrafiltration. When polylactide-<I>b</I>-poly(styrene-<I>co</I>-vinylbenzoyl chloride) (PLA-<I>b</I>-P(S-<I>co</I>-VBC)) in an organic phase and <I>m</I>-phenylenediamine (MPD) in an aqueous phase were used as the reactive block polymer and the amine, respectively, a block polymer thin film was successfully formed on a polysulfone support. This nanostructured film could be converted into a nanoporous layer by subsequent PLA etching under mild basic conditions. While most organic solvents used to dissolve PLA-<I>b</I>-P(S-<I>co</I>-VBC) damaged the support and decreased permeability of the resulting membrane, use of a mixture of methyl isobutyl ketone and acetonitrile produced a TFC membrane with high permeability.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/iecred/2014/iecred.2014.53.issue-48/ie5032259/production/images/medium/ie-2014-032259_0005.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ie5032259'>ACS Electronic Supporting Info</A></P>
Optimal Regional Trade-Integration Schemes in North Africa: Toward a Pro-Industrialization Policy
( Simon Mevel ),( Jaime Moll De Alba ),( Nassim Oulmane ) 세종대학교 경제통합연구소 2016 Journal of Economic Integration Vol.31 No.3
This article examines the status of industrial production in North African Countries as well as the role that regional trade integration through free-trade agreements and trade facilitation may play in spurring this region’s reindustrialization. The study uses Applied General Equilibrium model to assess the potential impact of the establishment of a Continental Free Trade Area as well as the reduction of costs to trade across borders. This article also measures the additional impact of the implementation of the Great Arab Free Trade Area and, finally, a deeper free trade agreement among North African countries and the European Union. The main findings indicate that each free-trade agreement configuration will stimulate, in relative terms, North African countries’ exports from a number of main industries. Whereas industrial products represent the largest share of North African countries’ export gains to Africa in general, mining and energy dominate North African countries’ export gains to the rest of the Arab League and food dominates the exports to the European Union. Therefore, the establishment of the Continental Free Trade Area, accompanied by trade-facilitation measures, appears to be crucial in providing support for North African countries’ industrialization.
Physical and Technological Limitations and Their Optimizations in Submicron ULSI Interconnect
Oh, Soo Young,Chang, Keh JEng,Moll, John L. 대한전자공학회 1991 ICVC : International Conference on VLSI and CAD Vol.2 No.1
The trend of the performance degradations, noise and reliability issues and their potential solutions are analyzed for the submicron ULSI interconnect lines. Ta analyze these submicron interconnect lines, a new paradigm(HIVIE) for fast and accurate 2-D and 3-D interconnect capacitances and resistances calculation is developed. The analysis, using these interconnect parameters from HIVE, shows that a copper(Cu) line will improve the electromigrations, but not the interconnect delay and cross-talk noise significantly. The low temperature operation improve the interconnect delay and electromigration, but it increases the cost of system packaging. The optimum approach will be the combination of additional layers of nan-scaled metal lines in a higher level and the use of repeaters to maximize the performance, noise and reliability and to minimize the risk and cost.