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Electrical stimulation modulates fibroblast through the collagen and MAPK pathway
( Un Cheol Yeo ),( Kwan Ho Jeong ),( Young Jun Woo ),( Hong Jin Joo ),( Jung Eun Kim ),( Hoon Kang ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.2
Background: Electrical stimulation (ES) have been studied in variable skin therapeutic conditions such as woundhealing. However, the underlying mechanism and optimal parameter settings are not clarified yet. Objectives: The aim of this study is to investigate the influence of alternative current (AC) ES on the underlying signaling pathway related to wound healing in human fibroblasts cells (hFBCs). Methods: Cultured hFBCs were electrically stimulated with different parameter settings (voltage: 3.5V, 6V, 8V/frequency: 1Mhz, 2Mhz) at AC. Collagen synthesis-related gene expressions were measured by real time-PCR. The protein levels of MAPK pathway and メ -SMA were measured by western blot assay. In animal model, different parameter settings of AC were applied to the shaved dorsal skin of rabbit for 16 days. Results: ES stimulated fibroblasts showed increased expression of wound healing factors such as collagen type 1, IGF-1, PDGF, TGFモ1, and TIMP/MMP ratio. ERK and AKT levels were significantly increased in 8V-1Mhz of ES compared to control group. Interestingly, the effect of AC (8V), as we observed the promote wound repair compare to control group in the rabbit skin. Conclusion: This study demonstrated that ES modulates fibroblast activities through the collagen and MAPK pathway, providing new insights related to the use of ES to promote wound healing.
MLSO 2 : Laser basics & physics
여운철 ( Un Cheol Yeo ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2
Laser treatment is so popular in cosmetic dermatologic treatment. But, the basic physics regarding laser treatment is so confusing. Whenever we encounter problem in laser treatment, we need to modify laser parameters according to individual cases. That is the moment we need vast variety of knowledge about laser basics and physics. Not only doctors but also paramecial persons should aware the mechanism of laser treatment to support doctor``s procedure. For this specific lecture, to enhance our understanding of laser, followings will be discussed 1. What is LASER ? light amplification by stimulated emission of radiation 2. Dosimetry energy(joule), power(watt), fluence(joule/cm2) fluence=dose=energy density fluence rate(W/cm2)= power density = irradiance = intensity 3. Laser tissue interaction reflection, scattering, transmission, absorption, 4. Chromophores in skin Water, oxy-hemoglobin, deoxy-hemoglobin, met-hemoglobin, melanin, fat 5. SPTL (selective photothermolysis) wavelength, pulse duration, fluence 6. Cooling cryogen spray cooling, contact cooling, air cooling
의학적 피부관리를 위한 의료기기의 사용과 법률에 대한 고찰
여운철 ( Un Cheol Yeo ),정찬우 ( Chan Woo Jeong ),한승경 ( Seung Kyung Hann ),김홍직 ( Hong Jig Kim ),한을남 ( Eul Nam Han ),박기범 ( Ki Beom Park ),최광호 ( Kwang Ho Choi ),목혜수 ( Hae Soo Mok ),문병천 ( Byung Chun Moon ),김용상 대한피부과학회 2009 대한피부과학회지 Vol.47 No.11
Background: Medical skin care is essential for the treatment of skin diseases all over the world. Medical skin care is also part of medical practice and this must be differentiated from the simple skin care that is given for normal healthy skin. Objective: We wanted to discuss medical skin care and the related medical devices and legal issues. Methods: We reviewed the related laws and regulations, we consulted experts and associations and we analyzed the result of the survey. Results: Legally, medical skin care and simple skin care are well classified. However, many illegal procedures are still performed by non-medical personnel and many adverse effects have been reported as a result. Furthermore, there are no legal restrictions for the performer based on the grade of each medical skin care procedure. Conclusion: For the best results and safe procedures, medical skin care must be performed by approved medical equipment under the supervision of a physician or medical personnel. Continuous control and guidance by the government is strongly needed. (Korean J Dermatol 2009;47(11):1236~1245)
림프부종 환자에서 Dermascan - C 와 조직생검을 이용한 피부 두께의 비교
여운철 ( Un Cheol Yeo ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.4
Background: Dermascan-C(Cortex technology, Denmark) is the 20MHz high-frequency ultrasonographic instrument which is suitable for skin measurement due to its high resolution compared to conventional 10MHz ultrasonographic machine. High frequency ultrasonography has been used for evaluating skin thickness by several investigators. There has been little data regarding to the evaluation of lymphedema using high-frequency ultrasonography. Objective : In this study, we examined skin thickness of lymphedema using Dermascan-C and compared the results with those of skin biopsy. Methods : Eight patients with various clinical stage of lymphedema were investigated. Skin biopsy and ultrasonographic measurement was done at the same lymphedema sites. In skin biopsy skin thickness was measured from horny layer to dermosubcutaneous junction. In ultrasonographic evaluation, the same site was measured using automatic algorithm provided by in-built image analyzer in Dermascan-C. Results : In five cases, the skin thickness measured by both methods are consistent, but in three cases it was impossible to measure skin thickness using Dermascan-C. Conclusion : Ultrasonographic evaluation using Dermascan-C could be useful to measure skin thickness in lymphedema. But, measuring skin thickness using Dermascan-C is difficult when the skin is very edematous or has subcutaneous fibrosis. (Kor J Derrnatol 1997;35(4): 752-757)
자외선에 의한 피부 염증 반응 : C57BL mouse의 귀부종 반응
여운철(Un Cheol Yeo),김기호(Ki Ho Kim),조미경(Mi Kyung Jo),전환표(Hwan Pyo Jeon),이주흥(Joo Heung Ree),이애영(Ai Young Lee),윤재일(Jai Il Youn) 대한피부과학회 1989 대한피부과학회지 Vol.27 No.6
This study was undertaken to investigate the change of ear swelling response (ESR) of the mice according to repetitive ultraviolet radiation. 100mJ/crn of UVB was irradiated daily for 4 weeks, and a total of 25 C57BL mice were used as subjects. The results were as follows : 1. After 1 day, 2 days and 3 days irradiation of UVB, ESR reached 21.3+1.5, 22.3+1.1 and 24.3+1.6 respectively with increasing tendency, but there was no statistical significance (Wilcoxon rank sum test p: 0.05). 2. ESR reached at maximum, 78.0+1.8, after 1 week(p<0.01), thereafter ESR decreased gradually with reparative process. 3. Inspite of continued irradiation, ESR decreased gradually after 2 weeks. After 2 weeks, 3 weeks and 4 weeks irradiation, ESR decreased to 51.6+11.8, 45.1+ 3.3 and 42.8-+6.8 respectively, but, there were still increment of ESR (p(0.01).
여운철 ( Un Cheol Yeo ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2
Laser treatment is so popular in cosmetic dermatologic treatment. But, the basic physics regarding laser treatment is so confusing. Whenever we encounter problem in laser treatment, we need to modify laser parameters according to individual cases. That is the moment we need vast variety of knowledge about laser basics and physics. Not only doctors but also paramecial persons should aware the mechanism of laser treatment to support doctor`s procedure. For this specific lecture, to enhance our understanding of laser, followings will be discussed 1. What is LASER ? light amplification by stimulated emission of radiation 2. Dosimetry energy(joule), power(watt), fluence(joule/cm2) fluence=dose=energy density fluence rate(W/cm2)= power density = irradiance = intensity 3. Laser tissue interaction reflection, scattering, transmission, absorption, 4. Chromophores in skin Water, oxy-hemoglobin, deoxy-hemoglobin, met-hemoglobin, melanin, fat 5. SPTL (selective photothermolysis) wavelength, pulse duration, fluence 6. Cooling cryogen spray cooling, contact cooling, air cooling.