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Zhang, Xingming,Le, Tuan-Anh,Hoshiar, Ali Kafash,Yoon, Jungwon IEEE 2018 IEEE/ASME transactions on mechatronics Vol.23 No.4
<P>Magnetic nanoparticles (MNPs) are a promising candidate for use as carriers in drug delivery systems. A navigation system with real-time actuation and monitoring of MNPs is inevitably required for more precise targeting and diagnosis. In this paper, we propose a novel electromagnetic navigation system with a coil combined with a soft magnetic core. This system can be used for magnetic particle imaging (MPI) and electromagnetic actuator functions with a higher steering force and enhanced monitoring resolution. A soft magnetic core with coils can increase the magnetic gradient field. However, this also generates harmonic noise, which makes it difficult to acquire MNP monitoring signals with MPI. Therefore, the use of amplitude modulation magnetic particle imaging (AM MPI) is suggested. AM MPI uses a low-amplitude excitation field combined with a low-frequency drive field. Using this system, the measured signal becomes less sensitive to the soft magnetic core. Based on the new MPI scheme and the combination of the coil with the magnetic cores, the proposed navigation system can implement one-dimensional (1-D) MNP navigation and 2-D MPI. The proposed navigation system can shorten the 1-D guidance time by about 25% for MNPs in the size range of 45–60 nm and give an improved 2-D imaging resolution of 43%, compared with an air-coil structure.</P>
Zhang, Xingming,Le, Tuan-Anh,Yoon, Jungwon Elsevier 2017 Journal of magnetism and magnetic materials Vol.427 No.-
<P><B>Abstract</B></P> <P>Targeted drug delivery using magnetic nanoparticles is an efficient technique as molecules can be directed toward specific tissues inside a human body. For the first time, we implemented a real-time imaging-based guidance system of nanoparticles using untethered electro-magnetic devices for simultaneous guiding and tracking. In this paper a low-amplitude-excitation-field magnetic particle imaging (MPI) is introduced. Based on this imaging technology, a hybrid system comprised of an electromagnetic actuator and MPI was used to navigate nanoparticles in a non-invasive way. The real-time low-amplitude-excitation-field MPI and electromagnetic actuator of this navigation system are achieved by applying a time-division multiplexing scheme to the coil topology. A one dimensional nanoparticle navigation system was built to demonstrate the feasibility of the proposed approach and it could achieve a 2Hz navigation update rate with the field gradient of 3.5T/m during the imaging mode and 8.75T/m during the actuation mode. Particles with both 90nm and 5nm diameters could be successfully manipulated and monitored in a tube through the proposed system, which can significantly enhance targeting efficiency and allow precise analysis in a real drug delivery.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A real-time system comprised of an electromagnetic actuator and a low-amplitude-excitation-field MPI can navigate magnetic nanoparticles. </LI> <LI> The imaging scheme is feasible to enlarge field of view size. </LI> <LI> The proposed navigation system can be cost efficient, compact, and optimized for targeting of the nanoparticles. </LI> </UL> </P>
ASEAN logistics network model and algorithm
Nguyen Thi-Yen,Nguyen Tuan-Anh,Zhang Jin 한국해운물류학회 2021 The Asian journal of shipping and Logistics Vol.37 No.3
Reasonable layout of logistics centers in the ASEAN countries has important practical significance for improving logistics network efficiency and reducing logistics transportation costs. This paper based on the current status of the ASEAN logistics network and the characteristics of the hub-and-spoke network, taking the minimum total cost as the optimization goal, establishing the central location model, and the design self-adaptive genetic algorithms to solve it. Therefore, the number of central nodes in the ASEAN logistics network has been determined, the radiation range between nodes, and route allocation. The results indicate that the ASEAN network layout model is a hub-and-spoke logistics network. With Singapore as the logistic center hub node. Jakarta logistics development belt will form the main radiating logistics demand cities of Kuching and Ho Chi Minh city. Kuala Lumpur logistics development belt’s main radiating logistics demand cities will be East Kalimantan and Da Nang city. Chon Buri logistics development belt mainly radiates the cities of Phnom Penh and Riau city. Bangkok logistics development belt mainly radiates the cities of Hanoi, Vientiane, and Yangon city.
Solubility of N-ethylcarbazole in ethanol+petroleum ether mixtures at various temperatures
Wenge Yang,Keyi Wu,Yong-Hong Hu,Tuan Zhang,Qirun Guo,Shouhai Yang,Ying Shi 한국화학공학회 2015 Korean Journal of Chemical Engineering Vol.32 No.6
The solubility of N-ethylcarbazole in (ethanol+petroleum ether) binary solvent mixtures was measured with the temperature changing from 280.15 K to 316.15 K. The experimental data matched the solvent/Redlich-Kister (CNIBS/R-K) equation and the Jouyban-Acree equation. Computational results showed the CNIBS/R-K equation was more suitable than the Jouyban-Acree equation. The solution process in the thermodynamic properties, including the Gibbs energy, enthalpy, and entropy, was calculated by the van’t Hoff analysis.
Anti-proliferative, anti-inflammatory and antioxidant effects of curcumin analogue A2
Zhi-Yun Du,Xingchuan Wei,Mou-Tuan Huang,Xi Zheng,Yue Liu,Allan H. Conney,Kun Zhang 대한약학회 2013 Archives of Pharmacal Research Vol.36 No.10
In the present study, we determined the antiproliferative,anti-inflammatory and antioxidant effects of acurcumin analogue, 2,6-bis(3,4-dihydroxybenzylidene) cyclohexanone(designated as A2). In vitro studies showed that A2had a stronger inhibitory effect on the growth of mousemacrophage RAW 264.7 cells than curcumin. A2 also showeda stronger inhibitory effect than curcumin on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced increases inNF-jB activation and IL-1b expression as well as in aldosereductase activity. A2 was a stronger antioxidant than curcuminas determined by inhibition of lipid peroxidation,inhibition of 1,1-diphenyl-2-picryl-hydrazyl free radical formation,and inhibition of 2,20-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) radical formation. In vivo studiesindicated that A2 was more potent than curcumin for inhibitingTPA-induced ear edema and TPA-induced increases inIL-1b. In addition, oral administration of A2 at a dose of2,000 mg/kg body weight did not cause acute toxicity inmice. Taken together, the results of our study indicate that thecurcumin analogue A2 has stronger anti-proliferative, antiinflammatoryand antioxidant activities than curcumin.
Contributed Mini Review : Isoforms, structures, and functions of versatile spectraplakin MACF1
( Li Fang Hu ),( Pei Hong Su ),( Run Zhi Li ),( Chong Yin ),( Yan Zhang ),( Peng Shang ),( Tuan Min Yang ),( Ai Rong Qian ) 생화학분자생물학회(구 한국생화학분자생물학회) 2016 BMB Reports Vol.49 No.1
Spectraplakins are crucially important communicators, linking cytoskeletal components to each other and cellular junctions. Microtubule actin crosslinking factor 1 (MACF1), also known as actin crosslinking family 7 (ACF7), is a member of the spectraplakin family. It is expressed in numerous tissues and cells as one extensively studied spectraplakin. MACF1 has several isoforms with unique structures and well-known function to be able to crosslink F-actin and microtubules. MACF1 is one versatile spectraplakin with various functions in cell processes, embryo development, tissue-specific functions, and human diseases. The importance of MACF1 has become more apparent in recent years. Here, we summarize the current knowledge on the presence and function of MACF1 and provide perspectives on future research of MACF1 based on our studies and others. [BMB Reports 2016; 49(1): 37-44]
Huaqian Wang,Dongli Li,Zhi-Yun Du,Mou-Tuan Huang,Xiaoxing Cui,Yujing Lu,Chenyue Li,Swee Lian Woo,Allan H Conney,Xi Zheng,Kun Zhang 한국식품과학회 2015 Food Science and Biotechnology Vol.24 No.3
Stems and leaves of Acanthopanax trifoliatus (L) Merr (AT) are commonly used as an edible vegetable in China. The scientific basis of antioxidant and antiinflammatory activities of AT was investigated. The polyphenol contents and free radical scavenging activities of AT ethanol extracts (EAT) were determined. Chlorogenic acid, isochlorogenic acid A, isochlorogenic acid C, and rutin were identified as major components in EAT. LPS-induced NO production in RAW264.7 cells was decreased significantly (p<0.05) after EAT treatment, compared with controls. In vivo studies indicated that EAT had more activity than chlorogenic acid per mg of dry weight for inhibition of TPA-induced ear edema. TPA-induced increases in cytokine production (TNF-α, IL-6, MMP-9, and TIMP-1) were significantly (p<0.05) reduced by EAT treatment, compared with controls. EAT exerts anti-inflammatory activities probably due, at least in part, to chlorogenic acid.
Song, Bo,Choi, Ji Il,Zhu, Yuntong,Geng, Zhishuai,Zhang, Le,Lin, Ziyin,Tuan, Chia-chi,Moon, Kyoung-sik,Wong, Ching-ping American Chemical Society 2016 Chemistry of materials Vol.28 No.24
<P>Three phenylenediamine (PD) monomers, o-phenylenediamine (OPD), m-phenylenediamine (MPD), and p-phenylenediamine (PPD), were used to prepare the functionalized graphene (PD/rGO) networks. The results obtained from a series of chemical, thermal, and rheological analyses elucidated the mechanism of the covalent bonding and the existence of cross-linked graphene networks. The measured XRD patterns and molecular dynamic calculations discovered that those PPD and MPD molecules could enlarge graphene interlayer spacing to 1.41 and 1.30 nm, respectively, while OPD molecules were disorderly bonded or nonbonded to the basal planes of graphene layers, resulting in small and variable inter layer distances. The loadings of PD monomers were optimized to achieve superior supercapacitor performance. Electrochemical study showed that PPD/rGO exhibited the largest specific capacitance of 422 F/g with excellent cycling stability and low charge transfer resistance. The large variations in the capacitance values among PD/rGO networks with different PD monomers were explained by the difference in the graphene nanostructures, reversible redox transitions, and charge transfer characteristics. Particularly, density function theory calculations were adopted to compare electronic properties of the PD/rGO composites, including formation energy, electron density distribution, HOMO energy levels, and electron density of states near the Fermi level.</P>