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트리클로로초산풀퍼릴의 염소화反應 : Chlorination of Furfuryl Trichloroacetate
金澤泳,김공수 成均館大學校 1967 論文集 Vol.12 No.-
3급 아민(피리민, 트리에틸 아민) 존재하에 플퍼릴 알코오올에 트리클로로 아세틸 클로라이드 또는 트리클로로 무수초산을 작용시켜 합성한 플퍼릴 트리클로로 아세테이트의 염소화 반응조건 및 염소화물의 산, 알카리 및 광선 온도에 대한 영향을 조사하였다. Furfuryl trichloroacetate, which synthesized using furfuryl alcohol and anhydrous trichloroacetic acid or trichloroacetyl chloride in the solution of tertiary amine (Pyridine, Teiethyl amine) and benzene, has been chlorinated in the presence of Iodine or anhydrous Aluminium chloride. Chlorinated product was to be stable and could separated by vacuum distillation without decomposition at low temperature. But as the lower chlorinated product could be detected at high temperature, the results show that the chlorinated product might be decomposed to the lower one at the high temperature.
급성 골수성 백혈병에서 Aclacinomycin , 6 - Thioguanine , ARA - C 복합 화학 요법의 치료 효과
이문호(Mun Ho Lee),이재훈(Jae Hoon Lee),김병국(Byoung Kook Kim),김노경(Noe Kyeong Kim),최강원(Kang Won Choe),이홍복(Hong Bock Lee),김승택(Seung Taik Kim),서철원(Cheol Won Suh),김시영(Si Young Kim),방영주(Yung Jue Bang) 대한내과학회 1988 대한내과학회지 Vol.34 No.2
N/A Thirty-three patients with AML (untreated 22 and relapsing 11) were treated with induction chemotherapy with Aclacinomycin, 6-Thioguanine and Ara-C, followed by 2 courses of consolidation chemotherapy only, The results were as following: 1) Complete remission rate was 64% in previously untreated patients, and 55% in relapsing patients, respectively. 2) Median duration of response was 47+ weeks in previously untreated, and 26 weeks in relapsing patients, respectively. 3) 1n previously untreated patients, median survival was 58+ weeks. 4) In patients with relapsing AML, median survival of overall patients was 27 weeks. 5) Median period of granulocytopenia (<500/mm3) was 17 days and median time to complete remission was 27 days. Infection was suspected in most cases during hypoplastic phase and caustive organisms were gram negative bacteria, staphylococcus and fungi in most cases. 6) Among the potential prognostic variables including age, inital WBC count, performacne status and peripheral blast count, none was statistically significantly related to complete remission rate. 7) Toxicities including anorexia, nausea, vomiting, headache, alopecia and stomatitis were of mild degree and no demonstable acute cardiotoxicities were observed.
급성백혈병의 관해수도시 trimethoprim sulfamethoxazole 의 간염예방효과에 관한 연구
최강원(Kang Won Choe),우준희(Jun Hee Woo),방영주(Yung Jue Bang),배현주(Hyun Joo Bae),서철원(Cheol Won Suh),김시영(Si Young Kim),박선양(Seon Yang Park),김병국(Byoung Kook Kim),김노경(Noe Kyeong Kim),김승택(Seung Taik Kim) 대한내과학회 1988 대한내과학회지 Vol.35 No.1
N/A Fifty patients with acute leukemia were studied during remission induction treatment in a prospectively radnomized trial to assess the effect of prophylactic trimethoprim/sulfamethoxazole on infection and fever rate. Twenty-three patients randomly received two single-strength trimethoprim/sulfamethoxazole tablets twice daily and twenty-seven patients did not receive any drugs. There were no significant differences in the duration of granulocytopenia, number of febrile days, or use of parenteral antibiotics. But trimethorpim/sulfamefhoxazole prophylaxis resulted in a reduced incidence of microbiologically documented infections (8 versus eighteen; p<0.05). This was mainly the result of a reduction in the episodes of bacteremia in the treatment group as compared with the contirol group. The number of patients without fever in the treatment group was eight compared to only 2 in the control group (p<0.05). Thus, trimethoprim/sulfamethoxazole prophylaxis during granulocytopenia reduced the incidence of microbiologically docummented infection and had more patients afebrile.
金俊榮,金淙澤 경북대학교 산업기술연구소 1987 産業技術硏究誌 Vol.15 No.-
The crystallinity and the thermal property of four graphites produced in Korea were studied by x-ray and DT/TGA. The sample OR exhibited to be most well graphitized crystal whereas the TH and GA were relatively well crystallized. The amorphous graphite SW had shown little crystallinity by x-ray diffractogram. DTA and TGA study of these graphite show significant difference in ignition temperature and heat of combustion according to the crystallinity.
Ultrasonographic Evaluation of the Endometrial Maturation in the Clomiphene Induced Menstrual Cycles
Rho, Yung Sook,Lee, Jin Woo,Jung, Jae Keun,Lim, Yong Taik,Kim, Seung Jo CATHOLIC MEDICAL CENTER 1986 Bulletin of the Clinical Research Institute Vol.14 No.1
The thrity-two clomiphene induced menstrual cycles were ultrasonographically monitored in order to evaluate the ultrasonographic phasic changes of uterine endometrial morphology and thickness with the follicular maturation (Dates: March, 1985 to February, 1986). 1. The ultrasonographic endometrial changes The ultrasonographic endometrial changes in the early proliferative phase was characterized by a long thin endometrium which became much thicker, giving evidence of growth in endometrial glands and stroma. The stromal cells of the superficial layer may be separated by transduate which was ultrasonographically demonstrated by a hyporeflective area. Following ovulation, we observed the 'ring' sign as an indirect evidence of ovulation. 2. The endometrial thickness The thickness of the central midline uterine echogenic area was 7.29 ± 1.63 ㎜ (Mean ± S.E.M.) in the early proliferative phase. These were 11.43 ± 1.38 ㎜, 11.85 ± 1.08 ㎜, 12.06 ± 1.39 ㎜, 12.52 ± 1.53 ㎜, 13.21 ± 1.81 ㎜, and 13.58 ± 1.61 ㎜, from Day -5 to Day 0 (= The day of ultrasonographic follicular rupture), respectively. It were also 13.66±2.09 ㎜ in the early secretory phase and 15.38±2.31 ㎜ in the late secretory phase, respectively. 3. The mid-luteal serum progesterone level The mean serum level of the mid-luteal progesterone was 22.77±8.75 ng/ml. We concluded that ultrasonographic monitoring of the endometrial morphology and thickness accompanying ovarian follicle monitoring is helpful in determining the endometrial dating as well as the confirmation of the progestational effect on the endometrial tissue and in detecting other organic pelvic disease related to infertility and menstrual disorders.
콩 發芽時의 糖의 代謝에 關한 硏究 (I) (Nucleotide 糖의 分離)
김택영,신현재,Kim, Taik-Yung,Shin, Hyun-Jae 대한화학회 1966 대한화학회지 Vol.10 No.2
Nucleotide galactose and glucose have been isolated during the soybean germination. Techniques for identification depends upon chromatography after elution the absorbed charcoal fraction with ethanol ammonia or 1/10N HCl.
Aspergillus Oryzae 의 α - Amylase 에 관한 연구
김택영,김수종 ( Taik Yung Kim,Soo Jong Kim ) 생화학분자생물학회 1980 BMB Reports Vol.13 No.2
The activity of α-amylase of Aspergillus Oryzae increases markedly in response to some added plant growth regulators; abscisic acid [3-methyl-5-(1`-hydroxy-4`-oxo-2`, 6`, 6`-trimethyl-2`-cyclohexen-1`-yl) cis, trans-2, 4-pentadienoic acid; ABA], gibberellic acid (2, 4a, 7-trihydroxy-1-methyl-8-methylen gibb-3-ene-1, 10-carboxylic acid-1, 4-latone; GA₃), and indole-3-acetic acid (IAA). The activity of α-amylase was increased as much as 1.20 times in the presence of 0.10μM ABA, 1.56 times in 0.01 μM IAA, and 0.24 times in 0.10μM GA₃. Time courses of these effect were studied to make comparisons in the maximum stationary phase. The optimum pH of enzyme was 5.80 and variable under the addition of several anions; Br^-, F^-, Cl^-, NO₃^-, and S^(2-). The relative activities were 100% in the presence of 0.04N Cl^-, 58.0% in the presence of 0.04N Br^-, 60.5% in the presence of 0.1N F^-, 39.2%in the presence of 0.1N NO₃^-, and 14.5% in the presence of 0.1N S^(2-).