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Neat Synthesis and Anti-oxidant Activity of α-Hydroxyphosphonates
Rao, K. Uma Maheswara,Sundar, Ch. Syama,Prasad, S. Siva,Rani, C. Radha,Reddy, C. Suresh Korean Chemical Society 2011 Bulletin of the Korean Chemical Society Vol.32 No.9
A simple efficient and neat synthesis of ${\alpha}$-hydroxy phosphonates has been accomplished from aromatic/heterocyclic aldehydes and diethyl phosphite using $KHSO_4$ as a catalyst under solvent-free conditions at ambient temperature. These compounds are characterized by spectral and analytical data and tested for their anti-oxidant activity.
Assessing the Systemic Toxicity in Rabbits after Sub Acute Exposure to Ocular Irritant Chemicals
Reshma, Cherian Sebastian,Sruthi, Sudhakaran,Syama, Santhakumar,Gayathri, Vishwanath,Mohanan, Parayanthala Valappil Korean Society of ToxicologyKorea Environmental Mu 2015 Toxicological Research Vol.31 No.1
Eye is a highly vascularised organ. There are chances that a foreign substance can enter the systemic circulation through the eye and cause oxidative stress and evoke immune response. Here the eyes of rabbits were exposed, for a period of 7 days, to 5 known ocular irritants: Cetyl pyridinium chloride (CPC), sodium salicylate (SS), imidazole (IMI), acetaminophen (ACT) and nicotinamide (NIC). The eyes were scored according to the draize scoring. Blood collected from the treated rabbit were analyzed for haematological and biochemical parameters. After sacrifice, histological analysis of the eye and analysis of pro-inflammatory biomarkers ($IL-1{\alpha}$, $IL-1{\beta}$, IL-8 and $TNF-{\alpha}$) in the cornea using ELISA was carried out. Spleen was collected and the proliferation capacities of spleenocytes were analyzed. Liver and brain were collected and assessed for oxidative stress. The eye irritation potential of the chemicals was evident from the redness and swelling of the conjunctiva and cornea. Histopathological analysis and ELISA assay showed signs of inflammation in the eye. However, the haematological and biochemical parameters showed no change. Spleenocyte proliferations showed only slight alterations which were not significant. Also oxidative stress in the brain and liver were negligible. In conclusion, chemicals which cause ocular irritation and inflammation did not show any systemic side-effects in the present scenario.
Assessing the Systemic Toxicity in Rabbits after Sub Acute Exposure to Ocular Irritant Chemicals
Cherian Sebastian Reshma,Sudhakaran Sruthi,Santhakumar Syama,Vishwanath Gayathri,Parayanthala Valappil Mohanan 한국독성학회 2015 Toxicological Research Vol.31 No.1
Eye is a highly vascularised organ. There are chances that a foreign substance can enter the systemic circulation through the eye and cause oxidative stress and evoke immune response. Here the eyes of rabbits were exposed, for a period of 7 days, to 5 known ocular irritants: Cetyl pyridinium chloride (CPC), sodium salicylate (SS), imidazole (IMI), acetaminophen (ACT) and nicotinamide (NIC). The eyes were scored according to the draize scoring. Blood collected from the treated rabbit were analyzed for haematological and biochemical parameters. After sacrifice, histological analysis of the eye and analysis of pro-inflammatory biomarkers (IL-1α, IL-1β, IL-8 and TNF-α) in the cornea using ELISA was carried out. Spleen was collected and the proliferation capacities of spleenocytes were analyzed. Liver and brain were collected and assessed for oxidative stress. The eye irritation potential of the chemicals was evident from the redness and swelling of the conjunctiva and cornea. Histopathological analysis and ELISA assay showed signs of inflammation in the eye. However, the haematological and biochemical parameters showed no change. Spleenocyte proliferations showed only slight alterations which were not significant. Also oxidative stress in the brain and liver were negligible. In conclusion, chemicals which cause ocular irritation and inflammation did not show any systemic side-effects in the present scenario.
Neat Synthesis and Anti-oxidant Activity of α-Hydroxyphosphonates
K. Uma Maheswara Rao,C. Radha Rani,S. Siva Prasad,Ch. Syama Sundar,C. Suresh Reddy 대한화학회 2011 Bulletin of the Korean Chemical Society Vol.32 No.9
A simple efficient and neat synthesis of α-hydroxy phosphonates has been accomplished from aromatic/heterocyclic aldehydes and diethyl phosphite using KHSO_4 as a catalyst under solvent-free conditions at ambient temperature. These compounds are characterized by spectral and analytical data and tested for their anti-oxidant activity.
Synthesis of New 8-Formyl-4-methyl-7-hydroxy Coumarin Derivatives
Manidhar, D.M.,Rao, K. Uma Maheswara,Reddy, N. Bakthavatchala,Sundar, Ch. Syama,Reddy, C. Suresh Korean Chemical Society 2012 대한화학회지 Vol.56 No.4
8-Formyl-4-Methyl-7-Hydroxy Coumarin Derivatives were synthesized via Penchem condensation followed by Duffs reaction. Treatment of this with N,N-di substituted cyano acetamides in the presence of piperdine afforded New 8-Formyl-4-Methyl-7-Hydroxy Coumarin Derivatives (7a-o). Their structures were characterized by IR, $^1H$ and $^{13}C$ NMR and Mass spectral and elemental analysis data.