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Kailasa, Suresh Kumar,Koduru, Janardhan Reddy,Desai, Mittal L.,Park, Tae Jung,Singhal, Rakesh Kumar,Basu, Hirakendu Elsevier 2018 Trends in analytical chemistry Vol.105 No.-
<P><B>Abstract</B></P> <P>Plasmonic metal nanoparticles have been explored as a new class of chemical read-outs for assaying of a variety of chemical and biological species because of their unique physico-chemical and size dependent properties. Metal nanoparticles-based optical technologies are based on either new class of organic molecular assembly or with aggregation-induced optical changes features, which can also improve the sensitivity of drug assays in pharmaceutical analysis. This review describes the advantages of surface chemistry of plasmonic metal nanoparticles (e.g., silver, copper, gold, and platinum) for tuning of their colorimetric sensing applications in various drugs assays in pharmaceutical and biological samples. It provides insights of various plasmonic metal nanoparticles-based sensing strategies for the selective, sensitive and simultaneous colorimetric assay of drugs in pharmaceutical samples. Finally, we listed some research challenges to accelerate the development of plasmonic metal nanoparticles-based colorimetric sensors that are directly applicable for assaying drugs in pharmaceutical samples.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Surface chemistry of plasmonic metal NPs plays key role in sensing of drugs. </LI> <LI> Progress on plasmonic metal NPs for assaying of various drugs is reviewed. </LI> <LI> Plasmonic metal NPs act as magnificent visual readouts for simultaneous analysis of drugs. </LI> <LI> Analytical performances of plasmonic metal NPs sensors were tabulated. </LI> </UL> </P>
Pinakin Patel,Pranav Mohan Singhal,Kamal Kishor Lakhera,Aishwarya Chatterjee,Agil Babu,Suresh Singh,Shubhra Sharma,Bhoopendra Singh Gora,Naina Kumar Agarwal 대한두개안면성형외과학회 2023 Archives of Craniofacial Surgery Vol.24 No.5
Background: Oral cavity cancers, the second most common type in India, are responsible for 10% of the overall cancer burden. With a recurrence rate of 30% to 40% and a 5-year survival rate of 50%, these malignancies account for substantial morbidity and mortality. Despite advances in treatment modalities, survival rates following treatment completion have not improved significantly. The present study aimed to establish specific epidemiological and pathological factors responsible for recurrence after treatment completion in buccal mucosa cancers. Methods: A retrospective analysis of the data of 116 patients treated for biopsy-proven cancers of the buccal mucosa was undertaken 1 year after treatment completion. Factors such as age, sex, education, lymphovascular invasion, extranodal extension (ENE), perineural invasion, depth of invasion, and pathological margin status were compared between patients who presented with recurrence and those who did not. Statistical significance was set at p< 0.05. Results: Of the 116 patients, 40 (34.5%) developed a recurrent disease within 1 year. The mean age of the study population was 43.3 years, and males constituted 91.4% of the included patients. Ipsilateral buccal mucosa was the commonest site of disease recurrence. Neck node metastasis, ENE, and margins of resection < 5 mm were significantly related to the recurrence of disease. However, surprisingly, lymphovascular invasion, perineural invasion, and depth of invasion > 10 mm did not show statistically significant associations. Conclusion: Neck node metastasis, ENE, and margins of resection < 5 mm were the histopathological factors associated with recurrence in cancers of the buccal mucosa.
Bhamore, Jigna R.,Jha, Sanjay,Singhal, Rakesh Kumar,Park, Tae Jung,Kailasa, Suresh Kumar Elsevier 2018 Journal of molecular liquids Vol.264 No.-
<P><B>Abstract</B></P> <P>In this work, we synthesized fluorescent carbon dots (CDs) using <I>Pyrus pyrifolia</I> (pear) fruit <I>via</I> hydrothermal method at 180 °C for 6 h without using any further treatment or surface passivating agents. The synthesized CDs possess intense blue fluorescence under UV lamp at 365 nm and exhibit emission peak at 471 nm when excited at 390 nm. Because of specific surface functional groups, the synthesized CDs showed high selectivity to detect Al<SUP>3+</SUP> ion through chelation enhanced fluorescence (CHEF) mechanism. The emission peak intensity of CDs at 471 nm was gradually enhanced with increasing concentration of Al<SUP>3+</SUP> ion, thereby Al<SUP>3+</SUP> ion was quantified by plotting calibration curve over the range of 0.005–50 μM with a detection limit of 0.0025 μM (2.5 nM). The nanoprobe was subsequently evaluated by assaying Al<SUP>3+</SUP> ion from spiked water samples, signifying the utility of nanoprobe for assaying of Al<SUP>3+</SUP> ion real samples. Furthermore, we also demonstrate that the bioimaging ability of CDs for imaging of <I>Bacillus subtilis</I> bacterial cell, suggesting that the nanoprobe can be used for cell imaging applications.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Fluorescent carbon dots are derived from <I>Pyrus pyrifolia</I> (pear) fruit. </LI> <LI> Al<SUP>3+</SUP> ion was detected <I>via</I> chelation enhanced fluorescence mechanism. </LI> <LI> Al<SUP>3+</SUP> ion detection limit is 0.0025 μM (2.5 nM). </LI> <LI> The CDs acted as probes for imaging of <I>Bacillus subtilis</I> bacterial cells. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>Schematic representation for fabrication of CDs using pear fruit and sensing of Al<SUP>3+</SUP> ion <I>via</I> chelation enhanced fluorescence mechanism.</P> <P>[DISPLAY OMISSION]</P>