A magneto-thermo-viscoelastic problem with fractional order strain under GN-II model

Sunita Deswal,Kapil Kumar Kalkal,Sandeep Singh Sheoran 국제구조공학회 2017 Structural Engineering and Mechanics, An Int'l Jou Vol.63 No.1

In this work, we present a theoretical framework to study the thermovisco-elastic responses of homogeneous, isotropic and perfectly conducting medium subjected to inclined load. Based on recently developed generalized thermoelasticity theory with fractional order strain, the two-dimensional governing equations are obtained in the context of generalized magneto-thermo-viscoelasticity theory without energy dissipation. The Kelvin-Voigt model of linear viscoelasticity is employed to describe the viscoelastic nature of the material. The resulting formulation of the field equations is solved analytically in the Laplace and Fourier transform domain. On the application of inclined load at the surface of half-space, the analytical expressions for the normal displacement, strain, temperature, normal stress and tangential stress are derived in the joint-transformed domain. To restore the fields in physical domain, an appropriate numerical algorithm is used for the inversion of the Laplace and Fourier transforms. Finally, we have demonstrated the effect of magnetic field, viscosity, mechanical relaxation time, fractional order parameter and time on the physical fields in graphical form for copper material. Some special cases have also been deduced from the present investigation.

Plane strain consolidation of a compressible clay stratum by surface loads

Rani, Sunita,Puri, Manoj,Singh, Sarva Jit Techno-Press 2014 Geomechanics & engineering Vol.7 No.4

An analytical solution of the fully coupled system of equations governing the plane strain deformation of a poroelastic medium with anisotropic permeability and compressible fluid and solid constituents is obtained. This solution is used to study the consolidation of a poroelastic clay layer with free permeable surface resting on a rough-rigid permeable or impermeable base. The stresses and the pore pressure are taken as the basic state variables. Displacements are obtained by integrating the coupled constitutive relations. The case of normal surface loading is discussed in detail. The solution is obtained in the Laplace-Fourier domain. Two integrations are required to obtain the solution in the space-time domain which are evaluated numerically for normal strip loading. Consolidation of the clay layer and diffusion of pore pressure is studied for both the bases. It is found that the time settlement is accelerated by the permeability of the base. Initially, the pore pressure is not affected by the permeability of the base, but has a significant effect, as we move towards the bottom of the layer. Also, anisotropy in permeability and compressibilities of constituents of the poroelastic medium have a significant effect on the consolidation of the clay layer.

Curcumin Induces Apoptosis in Pre-B Acute Lymphoblastic Leukemia Cell Lines Via PARP-1 Cleavage

Mishra, Deepshikha,Singh, Sunita,Narayan, Gopeshwar Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.8

Curcumin, a polyphenolic compound isolated from the rhizomes of an herbaceous perennial plant, Curcuma longa, is known to possess anticancerous activity. However, the mechanism of apoptosis induction in cancers differs. In this study, we have (1) investigated the anticancerous activity of curcumin on REH and RS4;11 leukemia cells and (2) studied the chemo-sensitizing potential of curcumin for doxorubicin, a drug presently used for leukemia treatment. It was found that curcumin induced a dose dependent decrease in cell viability because of apoptosis induction as visualized by annexin V-FITC/ PI staining. Curcumin-induced apoptosis of leukemia cells was mediated by PARP-1 cleavage. An increased level of caspase-3, apoptosis inducing factor (AIF), cleaved PARP-1 and decreased level of Bcl2 was observed in leukemia cells after 24h of curcumin treatment. In addition, curcumin at doses lower than the $IC_{50}$ value significantly enhanced doxorubicin induced cell death. Therefore, we conclude that curcumin induces apoptosis in leukemia cells via PARP-1 mediated caspase-3 dependent pathway and further may act as a potential chemo-sensitizing agent for doxorubicin. Our study highlights the chemo-preventive and chemo-sensitizing role of curcumin.

Obstetric outcome of induction of labor using prostaglandin gel in patients with previous one cesarean section

Vijayata Sangwan,Sunita Siwach,Pinki Lakra,Mukesh Sangwan,Sanjeet Singh,Rajiv Mahendru 대한산부인과학회 2019 Obstetrics & Gynecology Science Vol.62 No.6

ObjectiveAfter globally acceptance of planned vaginal birth after cesarean section (VBAC), the mode of induction is still amatter of debate and requires further discussion. We aimed to study obstetric outcomes in post-cesarean patientsundergoing induction of labor with prostaglandin gel compared with patients who developed spontaneous laborpains. MethodsAll patients at 34 weeks or more of gestation with previous one cesarean section eligible for trial of labor aftercesarean section admitted in a labor room within one year were divided in 2 groups. Group one consisted of patientswho experienced the spontaneous onset of labor pains and group 2 consisted of patients who underwent inductionof labor with prostaglandin gel. They were analyzed for maternofetal outcomes. Descriptive statistics, independentsample t-test, and chi-square test were applied using SPSS 20 software for statistical analysis. ResultsBoth groups were comparable in maternal age, parity, and fetal weight, but different in bishop score, mode ofdelivery, and neonatal outcome. Admisson bishop score was 6.61±2.51 in group 1 and 3.15±1.27 in group 2 (P<0.005). In the patients who experienced spontaneous labor, 86.82% had successful VBAC. In the patients with induced labor,64.34% had successful VBAC with an average dose of gel of 1.65±0.75. Both groups had one case each of uterinerupture. The neonatal intensive care unit admission rate was 4.1% in group one and 10.4% in group 2. ConclusionThis study reflects that supervised labor induction with prostaglandin gel in previous one cesarean section patients isa safe and effective option.

Demographic Risk Factors, Affected Anatomical Sites and Clinicopathological Profile for Oral Squamous Cell Carcinoma in a North Indian Population

Krishna, Akhilesh,Singh, R.K.,Singh, Shraddha,Verma, Pratima,Pal, U.S.,Tiwari, Sunita Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.16

Background: Oral cancer is a common form of cancer in India, particularly among men. About 95% are squamous cell carcinomas. Tobacco along with alcohol are regarded as the major risk factors. Objectives: (i) To determine associations of oral squamous cell carcinoma (OSCC) with respect to gender, age group, socioeconomic status and risk habits; (ii) To observe the distribution of affected oral anatomical sites and clinico-pathological profile in OSCC patients. Materials and Methods: This is an unmatched case-control study during period January 2012 to December 2013. Total of 471 confirmed OSCC patients and 556 control subjects were enrolled. Data on socio-demography, risk habits with duration and medical history were recorded. Results: There were significant associations between OSCC with middle age (41-50years; unadjusted OR=1.63, 95%CI=1.05-2.52, p=0.02) (51-60 years; unadjusted OR=1.79, 95%CI=1.15-2.79, p=0.009) and male subjects (unadjusted OR=2.49, 95%CI=1.89-3.27, p=0.0001). Cases with both habits of tobacco chewing and smoking were at a higher risk for OSCC than tobacco chewing alone (unadjusted OR=0.52, 95%CI=0.38-0.72, p=0.0001), duration of risk habits also emerged as a responsible factor for the development of carcinoma. The majority of patients were presented in well-differentiated carcinomas (39.9%). Prevalence of advance stages (TNM stage III, IV) was 23.4% and 18.3% respectively. The buccal mucosa was the most common (35.5%) affected oral site. Conclusions: In most Asian countries, especially India, there is an important need to initiate the national level public awareness programs to control and prevent oral cancer by screening for early diagnosis and support a tobacco free environment.

The current approach to the diagnosis of vascular anomalies of the head and neck: A pictorial essay

Goel, Sinny,Gupta, Swati,Singh, Aarti,Prakash, Anjali,Ghosh, Sujoy,Narang, Poonam,Gupta, Sunita Korean Academy of Oral and Maxillofacial Radiology 2015 Imaging Science in Dentistry Vol.45 No.2

Throughout the years, various classifications have evolved for the diagnosis of vascular anomalies. However, it remains difficult to classify a number of such lesions. Because all hemangiomas were previously considered to involute, if a lesion with imaging and clinical characteristics of hemangioma does not involute, then there is no subclass in which to classify such a lesion, as reported in one of our cases. The recent classification proposed by the International Society for the Study of Vascular Anomalies (ISSVA, 2014) has solved this problem by including non-involuting and partially involuting hemangioma in the classification. We present here five cases of vascular anomalies and discuss their diagnosis in accordance with the ISSVA (2014) classification. A non-involuting lesion should not always be diagnosed as a vascular malformation. A non-involuting lesion can be either a hemangioma or a vascular malformation depending upon its clinicopathologic and imaging characteristics.

Post-traumatic and postoperative neurosensory deficits of the inferior alveolar nerve in mandibular fracture: a prospective study

Yadav, Sunil,Mittal, Hitesh Chander,Malik, Sunita,Dhupar, Vikas,Sachdeva, Akash,Malhotra, Vijaylaxmy,Singh, Gurdarshan The Korean Association of Oral and Maxillofacial S 2016 대한구강악안면외과학회지 Vol.42 No.5

Objectives: We evaluated and recorded post-traumatic and postoperative neurosensory deficits of the inferior alveolar nerve (IAN) in mandibular fracture in order to identify associated risk factors. Materials and Methods: This was a prospective cohort study composed of 60 patients treated for mandibular fracture. The primary study variable was the change between the post-traumatic IAN neurosensory examination score and the score after fracture reduction. Risk factors were categorized as demographic, anatomic, fracture displacement, and treatment. Appropriate descriptive and bivariate statistics were computed. Results: Sixty patients with unilateral mandibular fracture reported within 24 hours of injury were evaluated over a one-year period. A post-traumatic neurosensory deficit was observed in 52 patients (86.7%), the percentage of which was reduced to 23.3% over the follow-up period. Abnormal postoperative neurosensory scores were significantly higher in angle fracture cases (33.3%) compared to body fracture cases (11.1%). When recovered and non-recovered neurosensory scores were compared by fracture location, 88.9% of body fracture cases showed significant recovery compared to 66.7% of mandibular angle fracture cases. Cases with less than 5 mm fracture displacement showed statistically significantly higher neurosensory recovery scores (90.6%) compared to those with more than 5 mm fracture displacement (60.7%). Conclusion: Use of a miniplate with mono-cortical screws does not play a role in increasing IAN post-traumatic neurosensory deficit. Early management can reduce the chances of permanent neurosensory deficit. Mandibular fracture displacement of 5 mm or more and fracture location were found to be associated with an increased risk of post-traumatic IAN neurosensory score worsening.

Intra-Operative Frozen Sections: Experience at A Tertiary Care Centre

Preeti, Agarwal,Sameer, Gupta,Kulranjan, Singh,Abhinav, Sonkar Arun,Preeti, Rani,Sunita, Yadav,Mati, Goel Madhu Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.12

The present study was conducted to assess error rates with diagnosis using intra-operative frozen sections, and to indicate ways to increase overall performance. Over a period of two years, 227 cases were biopsied intra-operatively. Errors were observed in 14 cases. Four of these were sampling errors, one by a pathologist and three by surgeons. In seven cases incorrect interpretations were made. Epithelial dysplasia was observed on definitive histology in two cases which was not reported intra-operatively. One case was of ectopic thyroid. In cases of oral cancer where sentinel lymph nodes were sampled, immunohistochemistry for cytokeratin was performed to facilitate identification of micrometastasis. Only single case displayed tumor deposits which was not evident morphologically. Resection margins were reported in seventy eight cases. Some 18% (14/50) benefited from revision of margins; overall sensitivity of intra-operative frozen sections for marginal status was 71.4%, with a specificity of 90.3%. Overall sensitivity was 75% and specificity was 97.5%. Careful observation, pathologist experience and knowledge of limitations help in improving the overall diagnostic outcome.

The current approach to the diagnosis of vascular anomalies of the head and neck: A pictorial essay

Sinny Goel,Swati Gupta,Aarti Singh,Anjali Prakash,Sujoy Ghosh,Poonam Narang,Sunita Gupta 대한영상치의학회 2015 Imaging Science in Dentistry Vol.45 No.2

Throughout the years, various classifications have evolved for the diagnosis of vascular anomalies. However, it remains difficult to classify a number of such lesions. Because all hemangiomas were previously considered to involute, if a lesion with imaging and clinical characteristics of hemangioma does not involute, then there is no subclass in which to classify such a lesion, as reported in one of our cases. The recent classification proposed by the International Society for the Study of Vascular Anomalies (ISSVA, 2014) has solved this problem by including non-involuting and partially involuting hemangioma in the classification. We present here five cases of vascular anomalies and discuss their diagnosis in accordance with the ISSVA (2014) classification. A non-involuting lesion should not always be diagnosed as a vascular malformation. A non-involuting lesion can be either a hemangioma or a vascular malformation depending upon its clinicopathologic and imaging characteristics.

Optimal panel of immunohistochemistry for the diagnosis of B-cell non-Hodgkin lymphoma using bone marrow biopsy: a tertiary care center study

Nisha Marwah,Manali Satiza,Niti Dalal,Sudhir Atri,Monika Gupta,Sunita Singh,Rajeev Sen 대한혈액학회 2021 Blood Research Vol.56 No.1

Background Morphological diagnosis of non-Hodgkin lymphoma (NHL) is usually based on lymph node biopsy. Bone marrow biopsy (BMB) is important for staging, and morphology alone can be challenging for subtyping. Immunohistochemistry (IHC) allows a more precise diagnosis and characterization of NHL using monoclonal antibodies. However, there is a need for a minimal panel that can provide maximum information at an affordable cost. Methods All newly diagnosed cases of B-cell NHL with bone marrow infiltration between 2017 and 2019 were included. BMB was the primary procedure for diagnosing B-cell NHL. Subtyping of lymphomas was performed by immunophenotyping using a panel of monoclonal antibodies on IHC. The primary diagnostic panel of antibodies for B-cell NHL included CD19, CD20, CD79, CD5, CD23, CD10, Kappa, and Lambda. The extended panel of antibodies for further subtyping included CD30, CD45, CD56, Cyclin D1, BCL2, and BCL6. Results All cases of B-cell NHL were classified into the chronic lymphocytic leukemia (CLL) and non-CLL groups based on morphology and primary IHC panel. In the CLL group, the most significant findings were CD5 expression, CD23 expression, dim CD79 expression, and weak surface immunoglobulin (Ig) positivity. In the non-CLL group, they were CD5 expression, positive or negative CD23 expression, strong CD79 expression, and strong surface Ig expression. An extended panel was used for further subtyping of non-CLL cases, which comprised CD10, Cyclin D1, BCL2, and BCL6. Conclusion We propose a two-tier approach for immunophenotypic analysis of newly diagnosed B-cell NHL cases with a minimum primary panel including CD5, CD23, CD79, Kappa, and Lambda for differentiation into CLL/non-CLL group and Kappa and Lambda for clonality assessment. An extended panel may be used wherever required for further subtyping of non-CLL.