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Efficacy of Ultraviolet A1 Phototherapy in Recalcitrant Skin Diseases
( Kee Suck Suh ),( Jin Seuk Kang ),( Jae Woo Baek ),( Tae Kwon Kim ),( Jin Woo Lee ),( Young Seung Jeon ),( Min Soo Jang ),( Sang Tae Kim ) 대한피부과학회 2010 Annals of Dermatology Vol.22 No.1
Background: Ultraviolet (UV) radiation has been used for decades to treat a variety of skin diseases. UVA1 was used initially as an effective treatment for acute exacerbated atopic dermatitis. Since then, UVA1 has been attempted for recalcitrant skin diseases. Objective: This study examined the efficacy of UVA1 phototherapy in three recalcitrant skin diseases. Methods: This retrospective study reviewed the efficacy and follow-up of 26 patients with atopic dermatitis (AD), mycosis fungoides (MF) and localized scleroderma (LS). SUPUVASUN 3000 (Mutzhas Co., Munich, Germany) and SELLAMED 3000 (Sellas Medizinische Gerate GmbH, Gevelsberg, Germany) were the UVA1 equipment used. Irradiation was performed in accordance with the disease. Low-dose (20 J/cm2), medium-dose (65 J/cm2) and high-dose regimens (100 J/cm2) of UVA1 therapy were employed. The frequency of the therapy ranged from 3 to 5 times weekly. The therapeutic effectiveness was assessed according to the clinical examination before and after the last treatment. Results: In patients with AD, complete and partial remission was achieved in four (80%) and one (20%) patient, respectively. In patients with MF, complete and partial remission was observed in thirteen (86.7%) and two (13.3%) patients, respectively. In patients with LS, complete and partial remission was observed in three (50%) and three (50%) patients, respectively. Conclusion: UVA1 phototherapy is an effective treatment modality for acute exacerbated AD, MF and LS. (Ann Dermatol 22(1) 1∼8, 2010)
Insulin Binding and its Action in Adipocytes of Hyperthyroid and Hypothyroid Rats
Kang, Sung Ku,Cha, Bong Yun,Kim, Young Woo,Bang, Byong Kee,Min, Byong Sok,Son, Ho Young,Lee, Kwang Woo,Kim, Hak Joong CATHOLIC MEDICAL CENTER 1986 Bulletin of the Clinical Research Institute Vol.14 No.1
The studies of the effects of thyroid hormone on insulin secretion and glucose metabolism have been made, but the results have been controversial. In order to evaluate the effects of thyroid hormone at the cellular level, insulin binding and insulin-induced lipogenesis in isolated rat epididymal fat cells were studied in control, hyperthyroid and hypothyroid rats. Hyperthyoidism was induced by daily intraperitoneal injection of sodium L-thyroxine and hypothyroidism by a single injection of ^131I. The adipocytes were isolated by treatment of collagenase as originally described by Gliemann (1967). The results were as follows: 1. The fasting serum insulin levels of hyperthyroid (21.6±3.7 uU/ml) and hypothyroid groups (20.5 ± 7.0 uU/ml) were not different from the value of control (23.1 ± 11 uU/ml). The fasting blood glucose level of hypothyroid group (164.9 ± 12.0 mg/dl) was higher than the values of the controls (148.2±13.2 mg/dl) or the hyperthyroid group (147.0±12.5 mg/dl), (p < .005). 2. The specific ^125l-insulin binding of the hyperthyroid group was not different from the value of the controls, but the value of the hypothyroid group was higher than the value of the controls (p<.005). 3. The insulin receptor concentration of the hypothyroid group (1.09±0.02ng/0.5×10exp(5) cells) was higher than the value of the controls (0.72±0.01ng/0.5×10exp(5) cells) or the hyperthyroid roup (0.79±0.02ng/0.5×10s cells), (p<.05). 4. The average affinities of the receptors in all groups showed an inverse correlation with the insulin concentration. The average affinity of the hypothyroid group was higher than the value of the control or the hyperthyroid group. 5. Insulin-induced lipogenesis was reduced proportionately in all insulin concentrations in both the hyperthyroid and hypothyroid groups compared with the dose-response curve of the control group. The maximal amount of Ilipogenesis of the hyperthyroid and hypothyroid groups were 63.4% (p<.05) and 32.3% (p<.005) of the controls, respectively. These studies suggest that thyroid hormone may regulate the concentration of insulin receptors, and altered thyroid states reduce insulin-induced lipogenesis in the adipocyte at post-receptor levels.
Characteristic Analysis of Multipurposal Sericinjam under Rearing
Kee-young Kim,Gyoo-byung Sung,Hae-yong Kweon,Mi-ja Kim,Sang-duk Ji,Nam-suk Kim,Pil-don Kang 한국응용곤충학회 2013 한국응용곤충학회 학술대회논문집 Vol.2013 No.10
7 new sericinjams are in breeding by the hybridization of silkworm genetic resource, that is, ND strain and the parent silkworm, and the feature of new sericinjam was classified by a cocoon color. According to cocoon color, sericinjam showed two kind of color including the light green and yellow. D601, D704 and D707 with the light green silk were a difference to density of color. Also D703, D705, D751 and D752 with the yellow silk showed a difference to density of color. As investigating the pupation rate which means the healthiness of the silkworm, D601 was highest with 93%, and D703 was lowest with 65.6%. The ratio of the sericin silk showed some difference every breed, and D601 among them was highest with 91%. There is close correlation between sericin cocoon quantity and the dried silkgrand weight. The weight of the dried silkgrand for sericinjams which were compared with baeokjam was low about 2.5 ~ 7.9 times. Among sericinjams, D601 was lowest, and D707 was highest. The pure sericin content of sericinjams was an above 96%, and sericin content of per one cocoon was low 1.4 ~ 2.5 times than baeokjam. Blood of silkworm which makes the light green silk exhibited anti bacterial activity against Gram-negative bacteria.