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Foreign Currency Noncore Bank Liabilities and Macroprudential Levy in Korea
( Sung Bin Cho ),( Joon Ho Hahm ) 한국국제경제학회 2014 한국국제경제학회 동계학술대회 Vol.2014 No.1
Recent research indicates that noncore liabilities of banks are highly procyclical and constitute an important transmission channel of global liquidity shocks to open emerging economies. Using the bank level data in Korea, we examine empirical properties of foreign currency noncore bank liabilities, and assess policy effectiveness of the macroprudential levy introduced in post-crisis Korea. Our panel regression and VAR analyses indicate that the foreign currency noncore bank liability ratio yields significant information on the vulnerability of banks, and the macroprudential levy has exerted non-trivial impacts on the noncore funding of banks leading to the mitigation of foreign currency liquidity risks of Korean banks. The findings of the present study strengthen the rationale for using appropriate macroprudential policies as a guard against financial vulnerability in open emerging economies.
Special Lecture : VEGF; Hot Track To Qualified Ulcer Healing
( Sang Woon Park ),( Min Ho Kim ),( Yong Seok Kim ),( Eun Jeong Jang ),( Joo Sang Park ),( Sang Jong Park ),( Hyun Wook Baik ),( Gregory Chung ),( Sung Won Cho ),( Ki Baik Hahm ) 대한소화기학회 2007 SIDDS Vol.9 No.-
Background and Aim: Irrespective of etiologies of peptic ulcer diseases (PUD), the most ulcers develop on the lesser curvature side of stomach including incisura and anterior wall of duodenal bulb. However, still no clear explanation why ulcers are prevalent in these areas has been given except some speculations including insufficient perfusion through abnormality in blood vessel, weak structural points or host characteristics. Here, we hypothesized that VEGF polymorphism can predict the susceptibility to peptic ulcer disease through deranged angiogenic activities. Methods: Based on several single nucleotide polymorphisms (SNPs) of vascular endothelial growth factor (VEGF) gene reported in literature search and their frequency studies done with Korean population, we performed the case-control study of 864 patients of chronic gastritis and gastric ulcer in 10 SNPs of VEGF gene including -2488 C/T, -634G/C, -7C/T, 3436G/C, 6112C/A, 6894C/T, 9374G/A, 9812C/T, 13128C/T, and 13553C/T, but of which results showed no statistically significant association between chronic gastritis and gastric ulcer. Results: We performed denatured high-performance liquid chromatography analysis to discover the novel SNP of VEGF gene, after which two novel SNPs of VEGF gene, -1780T/C and IVS-99 G/C, were identified, among which -1780T/C showed significant association between chronic gastritis and peptic ulcer disease, showing OR=2.93 on co-dominant analysis (p<0.001), OR=8.62 on dominant analysis (p<0.001), and OR=3.21 on recessive analysis (p<0.001). Promoter assay using site directed mutagenesis and in vitro angiogenesis assay showed repressed transcription of VEGF gene in gastric epithelial cells and defective tube formation in endothelial cells transfected with plasmid containing -1780C/C mutant of VEGF gene. Conclusion: Novel VEGF polymorphism, -1780T/C, is significantly associated with the predisposition to PUD after the exposure to etiologic risks.
Hahm, Young Hye,Hahm, Sung Ho,Jo, Hyoun Young,Ahn, Yeong Hee Hindawi 2018 International journal of analytical chemistry Vol.2018 No.-
<P>Glycosylation is one of the most important posttranslational modifications for proteins, including therapeutic antibodies, and greatly influences protein physiochemical properties. In this study, glycopeptide mapping of a reference and biosimilar recombinant antibodies (rAbs) was performed using liquid chromatography-electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) and an automated Glycoproteome Analyzer (GPA) algorithm. The tandem mass analyses for the reference and biosimilar samples indicate that this approach proves to be highly efficient in reproducing consistent analytical results and discovering the implications of different rAb production methods on glycosylation patterns. Furthermore, the comparative analysis of a mutagenized rAb glycoprotein proved that a single amino acid mutation in the Fc portion of the antibody molecule caused increased variations in glycosylation patterns. These variations were also detected by the mass spectrometry method efficiently. This mapping method, focusing on precise glycopeptide identification and comparison for the identified glycoforms, can be useful in differentiating aberrant glycosylation in biosimilar rAb products.</P>
안성은 ( Sung Eun Ahn ),이항락 ( Hang Lak Lee ),조승철 ( Seung Chul Cho ),윤재훈 ( Jai Hoon Yoon ),이오영 ( Oh Young Lee ),윤병철 ( Byung Chul Yoon ),최호순 ( Ho Soon Choi ),함준수 ( Joon Soo Hahm ),이민호 ( Min Ho Lee ),이동후 ( 대한소화기학회 2009 대한소화기학회지 Vol.53 No.4
목적: 허혈성 대장염의 임상 경과는 다양하나 대부분 보존 치료로 2-3일 내에 호전되나 드물게 수술 치료가 필요한 경우, 사망하는 경우도 있다. 저자들은 심한 임상경과를 예측할 수 있는 예후 인자들에 대해 알아보고자 연구를 시작했다. 대상 및 방법: 2004년부터 2006까지 한양대학교병원에 허혈성 대장염으로 진단받은 환자 41명을 경증과 중증으로 나누어 후향 분석하였다. 결과: 환자들의 평균연령은 63.8세였고, 남자 13명, 여자 28명이었다. 음주력이 있는 환자는 10명이고 흡연력은 11명이었다. 환자들의 기저질환은 고혈압 24명, 당뇨병 14명, 혈액 투석 중인 말기 신질환 11명, 심혈관 질환 5명, 악성 종양 5명이었다. 약물 복용력은 항혈소판제 11명, 항고혈압제 21명, 비스테로이드 항염증제 5명이었다. 처음 발현한 증상으로 복통, 혈변, 설사, 복막자극징후, 내원 당시 혈액검사, 대장 내시경 또는 복부 전산화 단층촬영에서 대장 침범 부위로 나누어서 중증의 허혈성 대장염으로의 진행 여부를 살펴보았다. 중증의 임상경과를 보인 경우는 남자(p=0.049), 음주력(p=0.025), 말기 신질환이 있을 때(p=0.013), 검사실 소견에서 LDH (p=0.002), CRP (p=0.014) 수치가 의미가 있었다. 신체검진에서는 복막자극징후(p=0.000)가 유의한 의미가 있었다. 여러 위험인자를 포함한 로지스틱 회귀 분석에서는 말기 신질환이 중증 허혈성 대장염의 유일한 위험인자였다. 결론: 말기 신질환 환자에서 허혈성 대장염은 중증으로 발전할 가능성이 높다. 따라서 허혈성 대장염이 발생한 말기 신질환 환자에서는 주의가 필요하다. Background/Aims: In general, ischemic colitis has a very good prognosis. However, there are a lot of controversies in relation to the prognostic factors. The aim of this study was to evaluate risk factors of severe ischemic colitis. Methods: A retrospective study was undertaken of patients with ischemic colitis hospitalized at the Hanyang University Hospital during the interval 2004-2006. Patients were divided into two groups: those with mild course and those with severe course which led to operation, systemic inflammatory response syndrome, or death. Results: A total of 41 cases (M/F=13/28, mean age=63.8 years) of biopsy proven ischemic colitis were included, of which 31 (75.6%) had a mild course and 10 (24.4%) a severe course. Coexisting medical diseases of patients were hypertension (n=24), diabetes (n=14), end-stage renal disease (n=11), cardiovascular disease (n=5), and malignancy (n=5). Male (p=0.049), alcoholics (p=0.025), end-stage renal disease (p=0.013), LDH (p=0.002), CRP (p=0.014), and peritoneal irritation sign (p=0.001) were the significant risk factors of severe ischemic colitis in univariate analysis. In multivariate logistic regression analysis, end-stage renal disease (p=0.026) was the only significant risk factor of severe ischemic colitis. Conclusions: Careful attention must be paid to end-stage renal disease patients having ischemic colitis. (Korean J Gastroenterol 2009;53:235-238)
Park, Sang-Ho,Kangwan, Napapan,Park, Jong-Min,Kim, Eun-Hee,Hahm, Ki Baik WJG Press 2013 World journal of gastroenterology Vol.19 No.47
<P>Although the International Agency for Research on Cancer declared Helicobacter pylori (H. pylori) as a definite human carcinogen in 1994, the Japanese Society for Helicobacter Research only recently (February 2013) adopted the position that H. pylori infection should be considered as an indication for either amelioration of chronic gastritis or for decreasing gastric cancer mortality. Japanese researchers have found that H. pylori eradication halts progressive mucosal damage and that successful eradication in patients with non-atrophic gastritis most likely prevents subsequent development of gastric cancer. However, those who have already developed atrophic gastritis/gastric atrophy retain potential risk factors for gastric cancer. Because chronic perpetuated progression of H. pylori-associated gastric inflammation is associated with increased morbidity culminating in gastric carcinogenesis, a non-microbial approach to treatment that provides long-term control of gastric inflammation through nutrients and other interventions may be an effective way to decrease this morbidity. This non-microbial approach might represent a new form of prerequisite 'rescue' therapy that provides a quicker path to the prevention of gastric cancer as compared to simple eradication.</P>
간 이식 후 합병된 담관 원주 증후군에 의한 폐쇄성 황달
백상현 ( Sang Hyun Bak ),최호순 ( Ho Soon Choi ),양선영 ( Sun Young Yang ),전대원 ( Dae Won Jun ),한성희 ( Sung Hee Han ),이항락 ( Hang Lak Lee ),이오영 ( Oh Young Lee ),윤병철 ( Byung Chul Yoon ),함준수 ( Jun Soo Hahm ),이민호 ( 대한소화기학회 2006 대한소화기학회지 Vol.48 No.2
Biliary complication occurs in 6-34% of all liver transplant patients. Although bile leaks and strictures are relatively common, other biliary complications such as T-tube leak, choledocholithiasis, and biliary cast syndrome can also be observed. The biliary cast syndrome describes the presence of casts causing obstruction with its resultant sequelae of biliary infection, hepatocyte damage secondary to bile stasis and ductal damage, all contributing to cholangiopathy. Because the exact timing of cast formation after orthotopic liver transplantation is not consistent, it is difficult to define the true incidence of biliary cast syndrome without long-term follow-up data. Proposed etiological mechanisms include acute cellular rejection, prolongation of cold ischemic time, infection, biliary drainage tubes, and biliary obstruction. The diagnosis of biliary cast syndrome is usually confirmed by endoscopic retrograde cholangiopancreatography. There have been few published articles about biliary casts in Korea. Herein, we report a case of biliary cast syndrome followed by orthotopic liver transplantation. (Korean J Gastroenterol 2006;48:119-123)
일반논문 : 총액배분자율편성제도의 효과에 관한 실증적 연구: 교육과학기술부 교육 분야 예산의 점증성을 중심으로
함성득 ( Sung Deuk Hahm ),이상호 ( Sang Ho Lee ),양다승 ( Da Sung Yang ) 서울대학교 한국행정연구소 2010 行政論叢 Vol.48 No.4
이 논문은 노무현 대통령의 참여정부가 2005년 도입한 ``총액배분자율편성제도``의 다양한 효과 중에서 점증적 예산편성관행의 개선효과를 분석하는데 초점을 두고, 교육과학기술부 교육 분야 정부제출 예산안을 분석대상으로 제도도입의 효과를 실증적으로 분석하였다. 구체적으로 본 논문은 제도시행 이전과 이후 교육과학기술부의 점증적 예산편성 행태의 변화를 비교하기 위해 2001년부터 2010년까지 교육 분야 예산을 대상으로 기술통계분석과 상관관계분석 그리고 Bailey & O`Connor(1975)와 Wildavsky(1984)의 점증성 기준을 활용하여 제도도입의 효과를 실증적으로 분석하였다. 그 결과 총액배분자율편성제도가 시행된 2005년 이후 교육과학기술부 교육 분야 사업들의 점증적 예산편성관행이 전반적으로 개선되면서 이 제도의 도입으로 기대되었던 효과가 일정부분 발휘되고 있었다. 즉 총액배분자율편성제도가 실시된 이후 교육과학기술부의 교육 분야 예산편성은 자원배분이 부처의 목표를 달성할 수 있도록 전략적으로 이루어지고, 점증성이 완화됨으로써 예산 배분의 효율성이 제고되는 방향으로 개선되고 있다. 다만 세부사업별로 아직까지 총액배분자율편성제도의 도입효과가 일관되게 나타나지는 않았다. This paper empirically examines changes in the budget for educational programs of the Korean Ministry of Education, Science, and Technology(MEST) from 2001 to 2010 to measure the effect of the top-down budgeting system of 2005. In particular, this paper analyzes the effect of the top-down budgeting system on the general accounts budget for educational programs of MEST`s planned budget before and after 2005 using descriptive analysis, correlation analysis, and the criteria of Bailey & O`Connor (1975) and Wildavsky(1984). The empirical results show the overall improvement of incremental budgeting practices in MEST after the introduction of top-down budgeting system. In other words, resources have been strategically allocated based on the investment priorities of the central budgeting agency by restructuring government projects in MEST.