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KO, Sang-Hwan,LEE, Geun-Shik,VO, Thuy T. B.,JUNG, Eui-Man,CHOI, Kyung-Chul,CHEUNG, Ki-Wha,KIM, Jae Wha,PARK, Jong-Gil,OH, Goo Taeg,JEUNG, Eui-Bae Society for Reproduction and Development 2009 Journal of Reproduction and Development Vol.55 No.2
<P>The effect(s) of oral calcium and vitamin D<SUB>3</SUB> were examined on the expression of duodenal and renal active calcium transport genes, i.e., calbindin-D9k (<I>CaBP-9k</I>) and calbindin-D28k (<I>CaBP-28k</I>), transient receptor potential cation channels (<I>TRPV5</I> and <I>TRPV6</I>), Na<SUP>+</SUP>/Ca<SUP>2+</SUP> exchanger 1 (<I>NCX1</I>) and plasma membrane calcium ATPase 1b (<I>PMCA1b</I>), in <I>CaBP-9k</I> KO mice. Wild-type (WT) and KO mice were provided with calcium and vitamin D<SUB>3</SUB>-deficient diets for 10 weeks. The deficient diet significantly decreased body weights compared with the normal diet groups. The serum calcium concentration of the WT mice was decreased by the deficient diet but was unchanged in the KO mice. The deficient diet significantly increased duodenal transcription of <I>CaBP-9k</I> and <I>TRPV6</I> in the WT mice, but no alteration was observed in the KO mice. In the kidney, the deficient diet significantly increased renal transcripts of <I>CaBP-9k</I>, <I>TRPV6</I>, <I>PMCA1b</I>, <I>CaBP-28k</I> and <I>TRPV5</I> in the WT mice but did not alter calcium-relating genes in the KO mice. Two potential mediators of calcium-processing genes, vitamin D receptor (VDR) and parathyroid hormone receptor (PTHR), have been suggested to be useful for elucidating these differential regulations in the calcium-related genes of the KO mice. Expression of VDR was not significantly affected by diet or the KO mutation. Renal <I>PTHR</I> mRNA levels were reduced by the diet, and reduced expression was also seen in the KO mice given the normal diet. Taken together, these results suggest that the active calcium transporting genes in KO mice may have resistance to the deficiency diet of calcium and vitamin D<SUB>3</SUB>.</P>
Dental management of a child with Arnold-Chiari malformation: A case report
Sang Mi Jo,Ko Eun Lee,Ok Hyung Nam,Hyo-Seol Lee,Sung Chul Choi,Kwang Chul Kim,Mi Sun Kim Asia Association for Disability and Oral Health 2020 대한장애인치과학회지 Vol.16 No.2
Arnold-Chiari malformation is a displacement of the tonsils and posterior vermis of the cerebellum through the foramen magnum, compressing the spinomedullary junction. The most common presenting symptoms are headache, cervical pain, back pain, motor weakness, loss of balance, dysphasia, tinnitus, and dysarthria. Other less common symptoms include seizure, obstructive sleep apnea, deafness, numbness of the face, and cranial malformation. In the present case, an 11-year-old female was referred to Department of Pediatric Dentistry at Kyung Hee University Hospital by an ophthalmologist for dental caries on the molars. The patient was diagnosed with Arnold-Chiari malformation. She underwent posterior fossa decompression and cranioclasty at seven years of age. Clinical examination showed poor oral hygiene and dental caries on the maxillary right first molar and mandibular left first molar. Given the patient’s behavior problem, cavity treatment and prophylaxis were performed under conscious sedation for about 1h with nitrous oxide inhalation and midazolam intramuscular administration. In addition, continuous follow-up checks were carried out with periodic prophylaxis for the prevention of dental caries and gingivitis. As the syndrome involves many different medical problems, special care should be considered. Additionally, dental treatment should be carried out in a comprehensive consultation system.
Severe airway obstruction and pleural effusion after arthroscopic shoulder surgery: a case report
Sang Hun Ko,Kwang Hwan Jung,Jae Ryong Cha,Min Chul Song,Chang-Gyu Choe 대한정형외과 스포츠의학회 2015 Arthroscopy and Orthopedic Sports Medicine Vol.2 No.2
Shoulder arthroscopy is used to treat a range of injuries of the shoulder and has many benefits, but it is also associated with undesirable complications. Even so, as the benefits by far surpass the risk, shoulder arthroscopy remains a common practice in orthopedics today. Here, we describe a previously unreported, potentially fatal complication, pleural effusion, after a shoulder arthroscopy. We removed the pleural effusion by thoracentesis with the patient in a beach-chair position.
A Measurement System for 3D Hand-Drawn Gesture with a PHANToM<sup>TM</sup> Device
Ko, Seong-Young,Bang, Won-Chul,Kim, Sang-Youn Korea Information Processing Society 2010 Journal of information processing systems Vol.6 No.3
This paper presents a measurement system for 3D hand-drawn gesture motion. Many pen-type input devices with Inertial Measurement Units (IMU) have been developed to estimate 3D hand-drawn gesture using the measured acceleration and/or the angular velocity of the device. The crucial procedure in developing these devices is to measure and to analyze their motion or trajectory. In order to verify the trajectory estimated by an IMU-based input device, it is necessary to compare the estimated trajectory to the real trajectory. For measuring the real trajectory of the pen-type device, a PHANToMTM haptic device is utilized because it allows us to measure the 3D motion of the object in real-time. Even though the PHANToMTM measures the position of the hand gesture well, poor initialization may produce a large amount of error. Therefore, this paper proposes a calibration method which can minimize measurement errors.
Ko, Ji-Yun,Park, Chang-Hwan,Koh, Hyun-Chul,Cho, Youl-Hee,Kyhm, Jee-Hong,Kim, Young-Soo,Lee, Inchul,Lee, Yong-Sung,Lee, Sang-Hun Blackwell Publishing Ltd 2007 Journal of Neurochemistry Vol.103 No.4
<P>Abstract</P><P>Human embryonic stem (hES) cells can be guided to differentiate into ventral midbrain-type neural precursor (NP) cells that proliferate <I>in vitro</I> by specific mitogens. We investigated the potential of these NP cells derived from hES cells (hES-NP) for the large-scale generation of human dopamine (DA) neurons for functional analyses and therapeutic applications. To address this, hES-NP cells were expanded <I>in vitro</I> for 1.5 months with six passages, and their proliferation and differentiation properties determined over the NP passages. Interestingly, the total hES-NP cell number was increased by > 2 × 10<SUP>4</SUP>-folds over the <I>in vitro</I> period without alteration of phenotypic gene expression. They also sustained their differentiation capacity toward neuronal cells, exhibiting <I>in vitro</I> pre-synaptic DA neuronal functionality. Furthermore, the hES-NP cells can be cryopreserved without losing their proliferative and developmental potential. Upon transplantation into a Parkinson’s disease rat model, the multi-passaged hES-NP cells survived, integrated into the host striatum, and differentiated toward the neuronal cells expressing DA phenotypes. A significant reduction in the amphetamine-induced rotation score of Parkinson’s disease rats was observed by the cell transplantation. Taken together, these findings indicate that hES-NP cell expansion is exploitable for a large-scale generation of experimental and transplantable DA neurons of human-origin.</P>
Development of a Multiple SMPS System Controlling Variable Load Based on Wireless Network
Ko, Junho,Park, Chul-Won,Kim, Yoon Sang The Korean Institute of Electrical Engineers 2015 Journal of Electrical Engineering & Technology Vol.10 No.3
This paper proposes a multiple switch mode power supply (SMPS) system based on the wireless network which controls variable load. The system enables power supply of up to 600W using 200W SMPS as a unit module and provides a controlling function of output power based on variable load and a monitoring function based on wireless network. The controlling function for output power measures the variation of output power and facilitates efficient power supply by controlling output power based on the measured variation value. The monitoring function guarantees a stable power supply by observing the multiple SMPS system in real time via wireless network. The performance of the proposed system was examined by various experiments. In addition, it was verified through standardized test of Korea Testing Certification. The results were given and discussed.
Construction and Characterization of Novel Expression Vectors for Genetic Adipose Tissue Ablation
Ko, Duck Sung,Choi, Woong Hwan,Kim, Chul Geun The Korean Society for Integrative Biology 1998 Korean journal of biological sciences Vol.2 No.2
Obesity, one of the most common metabolic diseases in industrial countries is characterized by an increase in the number or size of adipocytes. In an effort to create transgenic mouse models for the study of obesity we developed a novel technique in which adipose tissue can be ablated genetically at will, at any specific developmental stage and/or physiological condition, by the treatment of ganciclovir. We made a series of adipocytespecific expression vectors using minimal regulatory regions of brown adipocyte-specific uncoupling protein (UCP-1) gene and adipocyte-specific aP2 gene, and then analyzed their expression characteristics in cultured cell lines. When both constructs pUCP-LacZ and paP2-LacZ were transfected transiently into differentiating 3T3-L1 (pre-while adipocytes) and HIB-1B (pre-brown adipocytes) cell lines in vitro and then monitored by X-gal staining of cells, these regulatory regions were sufficient to show proper differentiation stage-specific expression in adipocvtes. To confirm that adipocytes expressing HSV-TK controlled by these minimal requlatory elements are sufficient to kill themselves with ganciclovir treatment pUCP-TK and paP2-TK expression constructs were transfected stably into HIB-1B and 3T3-L1 cells, respectively, and their ganciclovir sensitivities were tested during in vitro differentiation of cells. As expected more than 80% of cells were dead by the 7th day of treatment with ganciclovir while negative control cells were not affected at all. The data suqqest that the constructed vectors are suitable for obtaining novel obese transqenic models based on a conditional genetic tissue ablation method.