안면부에 발생한 비특이성 염증

유동수,박태원,박래정,최순철,정환석,현영민 大韓口腔顎顔面 放射線學會 1997 Imaging Science in Dentistry Vol.27 No.1

Patient with complaints of swelling, pain in the maxillary region and discomfort visited Seoul National University Dental Hospital in August last year. Clinical examination and diagnostic imagings implied he was suffered from fungal hyphal infection but no causative fungus was found by the histopathologic and microbiologic investigation. Therefore he was diagnosed with nonspecific inflammation. But as yet, we do think this case is very similiar to some kinds of mucormycosis. So we presented this case for more thorough discussion. Followings are founded in the examination. 1. Patient had suffered from Diabetes mellitus and complained of stuffness, headache, swelling in buccal checks and paresthesia. And we found more maxillary bony destruction and ulcer with elevated margin in the palate by clinical examination. 2. In the first visit, Plain films revealed general bony destruction of the maxilla, radiopaqueness in the sinonasal cavities. CT and MRI showed soft tissue mass filled in the paranasal sinus except frontal sinus and bony destruction in involved bones. 3. No causative bacteria and fungus was found in the biopsy and microbiologic cultures. 4. Caldwell-Luc operation and curettage were carried and antibiotics were taken for 4 months. But now he was worse than in the past. 5. In the second visit, involvement of orbit, parapharyngeal sinus, clivus, cavernous sinus and middle cranial fossa were seen clearly in the CT and MRI.

皮膚科 外來 癩患者의 動態

宋浚榮,朴義守,徐舜鳳,徐基錫,河龍馬,孫在卿,金基洪,金蘭姬 大韓癩學會 1981 癩學 會誌 Vol.14 No.1

흑조위축병 바이러스 RNA 를 절단하는 망치머리형 라이보자임의 제작

박종석(Jong Sug Park),김주곤(Ju Kon Kim),손성한(Seong Han Sohn),이석순(Sug Soon Lee),황영수(Young Soo Hwang) 한국응용생명화학회 1995 Applied Biological Chemistry (Appl Biol Chem) Vol.38 No.6

To develop an antiviral agent for the rice black-streaked dwarf virus (RBSDV), a hammerhead type ribozyme, which has a potential target site on the genome segment 3, was designed. Oligonucleotides for the ribozyme and its substrate were synthesized, annealed, and cloned into a plasmid pBluescript II KS(+). Ribozyme and substrate RNAs were then synthesized by in vitro transcription with T₃ RNA polymerase, obtaining RNAs in expected size, 193 and 182 nucleotides, respectively. The substrate RNA was efficiently cleaved into two fragments when incubated with the ribozyme at 55℃, while the cleavage was not detected at 37℃. In addition, the segment 3 RNA of RBSDV was also cleaved into two fragments by the same ribozyme at 55℃. Taken together, our results demonstrated that the hammerhead ribozyme has an in vitro endonucleolytic activity and may be used as an antiviral agent in transgenic plants.

A New Soybean Cultivar for Soy Sauce and Paste with Disease Resistance and High Yielding "Jinmi"

Sug Kee Suh,Young Jin Oh,Ho Ki Park,Kyong Ho Kim,Hag Sin Kim,Moon Soo Park,Duck Yong Suh,Soon Chul Kim 한국육종학회 2003 한국육종학회지 Vol.35 No.2

A new soy sauce and soy paste soybean variety, “Jinmi” was developed from the cross between HS12 (Jangyeobkong/Hwangkeumkong) and Mallikong by the soybean breeding team of the National Honam Agricultural Experiment Station in 2001. The preliminary, advanc

Toward next generation large optical telescope for Korean astronomy I. precision CNC grinding and metrology

Sug-Whan Kim,Ho-Soon Yang,Geon-Hee Kim,Jeong-Yeol Han,Ju-Hwan Kim,Hyung-Gon Kim 한국천문학회 2003 天文學會報 Vol.28 No.1

Direct detection of cariogenic streptococci in metal brackets in vivo using polymerase chain reaction

Ahn, Sug-Joon,Lee, Shin-Jae,Baek, Seung-Hak,Kim, Tae-Woo,Chang, Young-Il,Nahm, Dong-Seok,Lim, Bum-Soon 대한치과교정학회 2005 대한치과교정학회지 Vol.35 No.4

Streptococcus mutans와 Streptococcus sobrinus는 교정장치 주위의 법랑질 탈회를 유발하는 중요한 원인균들이다. 본 연구는 중합효소연쇄반응법을 이용하여 생체 브라켓에 존재하는 이들 균주의 이환율을 평가하기 위해 고안되었다. 상악과 하악치열의 절치 브라켓 각각 4개를 교정치료 종료 시점에서 채취하였다. 브라켓에 부착된 세균들의 DNA를 추출하고 각각의 세균에 해당하는 프라이머를 이용하여 덱스트란 분해효소를 증폭시켰다. 본 연구의 결과는 S. mutans와 S. sobrinus가 하악절치 브라켓에 비해 상악절치 브라켓에 더 많이 존재함을 보여주었으며, 이들 브라켓에 존재하는 세균의 빈도는 이전의 연구에서 구강내에 존재하는 빈도에 비해 더 적음을 보여주었다. S. mutans의 상악절치 브라켓 이환율은 50.0%, 하악절치 브라켓 이환율은 33.8%였고, S. sobrinus는 각각 17.5, 15.0%였다. 상악절치 브라켓에 두 종류의 세균이 모두 이환된 환자는 7명(8.8%)였으며, 하악절치 브라켓에 두 종류의 세균이 모두 이환된 환자는 5명(6.3%)였다. 본 연구의 결과는 법랑질 탈회를 유발하는 치아우식증 원인균이 절치 브라켓에 부착하는 상주균일 가능성을 제시한다. Streptococcus mutans and Streptococcus sobrinus are major etiological agents in enamel demineralization around orthodontic appliances. This study was designed to examine the prevalence of these streptococci on orthodontic brackets in vivo using polymerase chain reaction. Four incisor brackets in the upper and lower arches were removed and collected from 80 patients at the time of debonding. The genomic DNA of adhered bacteria was extracted and each dextranase gene of S. mutans and S. sobrinus was amplified using the specific oligonucleotide primers. The results showed that the maxillary incisor brackets were colonized by both cariogenic streptococci to a somewhat higher degree than that taken from the mandible. The prevalence of S. mutans was 50.0% on the maxillary incisor brackets and 33.8% on the mandibular incisor brackets, and that of S. sobrinus was 17.5% and 15.0%, respectively. Both species were detected on the maxillary incisor brackets of 7 patients (8.8%) and the mandibular incisor brackets of 5 patients (6.3%). These results suggest that cariogenic streptococci can adhere to the incisor brackets and may be resident species on the incisor brackets.

협업형 사실검증 서비스의 의의와 과제

최순욱(Soon-wook Choi),윤석민(Sug-min Youn) 사이버커뮤니케이션학회 2017 사이버 커뮤니케이션 학보 Vol.34 No.2

국내 미디어 관련 학계, 업계가 일제히 ‘가짜 뉴스’, ‘페이크 뉴스(fake news)’, ‘사실 검증(fact check)’을 주목하고 있다. 여기에는 2016년 진행된 미국 대선에서 도널드 트럼프(Donald Trump)가 당선된 것이 영향을 미친 것으로 보인다. 당시 언론들은 예상을 뒤엎은 트럼프 후보의 당선을 설명할 수 있는 원인을 찾았는데, 여기에 대한 답으로 ‘허무맹랑한 내용의 뉴스를 가장한 정보(가짜 뉴스)’가 SNS를 타고 광범위하게 유통되며 유권자들의 표심에 영향을 미쳤다는 분석이 제시되었다. 이는 현재 전 세계적으로 가짜 뉴스의 영향력을 우려하는 움직임들이 일어나는 것과 관련이 있다. 그러나 가짜 뉴스의 유통을 막는 것은 쉬운 일이 아니다. 섣불리 특정 유형의 정보를 가짜 뉴스라고 정의하고 제도, 법 등으로 규제하기 시작하면 표현의 자유를 심각하게 침해할 우려가 있다. 이 때문에 이미 오래 전에 언론의 중요한 기능이자 역할로 인정받았던 사실 검증의 가치와 방법이 재조명받고 있다. 〈SNU팩트체크(SNU FactCheck)〉는 이런 상황에서 서울대학교 언론정보연구소가 16개 언론사와 연합해 2017년 3월 말 시작한 ‘협업형 사실 검증 웹서비스’다. 서울대학교 언론정보연구소는 사실 검증 결과를 통일된 형식으로 표현하고 웹을 통해 배포할 수 있는 척도와 시스템을 제공하고 서비스에 참여하는 언론사들은 여기에 게재될 사실 검증 결과물을 작성한다. 본 논문에서는 사실 검증에 대한 〈SNU팩트체크〉의 기본적 관점과 서비스의 작동 방식, 주요 특징을 설명한다. 이와 함께 〈SNU팩트체크〉의 한계 및 과제에 대해서도 논의할 것이다. 이를 통해 〈SNU팩트체크〉가 언론계와 학계에 시사하는 바를 종합적으로 검토하고자 한다. Media related academics and industry are paying attention to ‘fake news’ and ‘fact check’. It seems that it is related to the election of Donald Trump in the 2016 US presidential election. After the election, the media tried to explain Trump’s election, which overturned the expectation, and many people insisted that fake news was widely circulated on SNS and influenced on voter’s decision. This influenced the movement of fears about the influence of fake news around the world. These claims have affected various movements around the world to prevent the distribution of fake news. But it is not easy to stop the distribution of fake news. If you start to define certain types of information as fake news too easily and regulate it by law, freedom of expression is likely to be seriously infringed. For this reason, the value and method of fact-checking, which has long been recognized as an important function and role of the media, has been reexamined. 〈SNU FactCheck〉 is a collaborative fact-checking web service launched in March 2017 by Institute of Commucation Research(ICR) of Seoul National University, in cooperation with 16 media companies. With 〈SNU FactCheck〉, ICR provides a system that can express the results of fact-check in a unified format and distribute it through the web. Participating media companies use the system to select what to check and conduct the factual verification. In this paper, authors explain the basic point of view about ‘fact’ in 〈SNU fact check〉, how to operate the service, and the main features. The limitations and challenges of the 〈SNU FactCheck〉 also will be discussed. Through this, authors would like to review the implications of 〈SNU FactCheck〉 for journalism and academia.

Mutations in the gyrB, parC, and parE Genes of Quinolone-Resistant Isolates and Mutants of Edwardsiella tarda

( Myoung Sug Kim ),( Lyu Jin Jun ),( Soon Bum Shin ),( Myoung Ae Park ),( Sung Hee Jung ),( Kwang Il Kim ),( Kyung Ho Moon ),( Hyun Do Jeong ) 한국미생물 · 생명공학회 2010 Journal of microbiology and biotechnology Vol.20 No.12

The full-length genes gyrB (2,415 bp), parC (2,277 bp), and parE (1,896 bp) in Edwardsiella tarda were cloned by PCR with degenerate primers based on the sequence of the respective quinolone resistance-determining region (QRDR), followed by elongation of 5` and 3` ends using cassette ligation-mediated PCR (CLMP). Analysis of the cloned genes revealed open reading frames (ORFs) encoding proteins of 804 (GyrB), 758 (ParC), and 631 (ParE) amino acids with conserved gyrase/topoisomerase features and motifs important for enzymatic function. The ORFs were preceded by putative promoters, ribosome binding sites, and inverted repeats with the potential to form cruciform structures for binding of DNA-binding proteins. When comparing the deduced amino acid sequences of E. tarda GyrB, ParC, and ParE with those of the corresponding proteins in other bacteria, they were found to be most closely related to Escherichia coil GyrB (87.6% identity), Klebsiella pneumoniae ParC (78.8% identity), and Salmonella Typhimurium ParE (89.5% identity), respectively. The two topoisomerase genes, parC and parE, were found to be contiguous on the E. tarda chromosome. All 18 quinolone-resistant isolates obtained from Korea thus far did not contain subunit alternations apart from a substitution in GyrA (Ser8→Arg). However, an alteration in the QRDR of ParC (Ser84→Ile) following an amino acid substitution in GyrA (Asp87→Gly) was detected in E. tarda mutants selected in vitro at 8 μg/ml ciprofloxacin (CIP). A mutant with a GyrB (Ser464→Leu) and GyrA (Asp87→Gly) substitution did not show a significant increase in the minimum inhibitory concentration (MIC) of CIP. None of the in vitro mutants exhibited mutations in parE. Thus, gyrA and parC should be considered to be the primary and secondary targets, respectively, of quinolones in E. tarda.

롤 가압을 통한 저잔류층 나노임프린트 공정기술 연구

이순원(Soon-Won Lee),박성제(Seong-Je Park),정준호(Jun-Ho Jeong),이응숙(Eung-Sug Lee),최준혁(Jun-Hyuk Choi) 대한기계학회 2010 대한기계학회 춘추학술대회 Vol.2010 No.11

The present work tried to achieve the goal of improving areal uniformity and minimizing residual thickness through applying roll pressing. Soft mold of PUA (poly(urethane acrylate)) was first replicated from the master pattern comprised of hexagonal hole array of photonic crystals in pitch size of 540 ㎚ and height of 270㎚. It was wrapped around quartz roll with no separate adhesive film, and made in contact with silicon substrate. A drop of UV curable resin was dispensed just before roll imprint start, so that it is supposed to fill only into the empty space between nanopatterns in the soft mold and flat silicon substrate. UV exposure is made in the center of quartz roll, and illuminated toward the contact area because the resin in open space will not cure at the presence of oxygen. We achieved almost zero residual layer in the custom-designed process roll, while a problem of incompletely-cured resin created tilted shape of nanoholes.

The effects of orthodontic bonding steps on biofilm formation of <i>Streptococcus mutans</i> in the presence of saliva

Ahn, Sug-Joon,Cho, Eun-Jung,Oh, Sung-Suk,Lim, Bum-Soon Informa Healthcare 2012 Acta odontologica scandinavica Vol.70 No.6

<P><B><I>Objective.</I></B> To investigate the effects of various orthodontic bonding steps on biofilm formation of <I>Streptococcus mutans</I> in the presence of saliva. <B><I>Materials and methods:</I></B> Hydroxyapatite (HA) and orthodontic adhesive (AD) disks were prepared to a uniform size. HA disks were etched with 37% phosphoric acid gel in the etched group (HE). In the primed group (HP), Transbond XT primer was applied to the etched HA surface and light-cured. For biofilm formation, <I>Streptococcus mutans</I> was grown on each specimen in a biofilm medium with either glucose or sucrose in the presence of fluid-phase UWS (F-UWS) or surface adsorbed saliva (S-UWS). The adherent bacteria were quantified by enumeration of the total viable counts of bacteria. Biofilms formed on each surface were examined by scanning electron microscopy. <B><I>Results.</I></B> When glucose was used, both F-UWS and S-UWS suppressed biofilm formation of <I>S. mutans.</I> Compared to HA and HE, biofilm formation was significantly inhibited on HP and AD in the presence of glucose. Biofilm-forming patterns that were inhibited by saliva were restored in a sucrose-containing medium. F-UWS promoted biofilm formation on HA and HE, while S-UWS significantly promoted biofilm formation on HP. <I>S. mutans</I> developed biofilm better on HA and HE than on AD when sucrose was used as the sole carbohydrate source. <B><I>Conclusions.</I></B> This study suggests that the biofilm development by <I>S. mutans</I> is significantly influenced by the orthodontic bonding procedure. Biofilm formation of <I>S. mutans</I> was inhibited on AD more than other surfaces, irrespective of the presence of saliva or a carbohydrate source.</P>