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RISS 인기검색어
- 검색키워드
- 저자 : Stratford, Michael R (검색결과 5 건)
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Árbol de Diana in German : Giving a new look to Pizarnik’s voice
Stratford, Madeleine 이화여자대학교 통역번역연구소 2014 T&I review Vol.4 No.-
Recently, Argentine poet Alejandra Pizarnik (1936-1972) has been gaining visibility in German translation, especially since the 2002 publication of Cenizas – Asche, Asche, translated by Juana and Tobias Burhardt. That anthology introduces Pizarnik’s six most important poetry books in German translation, including Árbol de Diana. Alghough excerpts had previously been translated into German by others, the Burghardts are the first to tackle all 38 poems. In their postscript, they declare that they translated Pizarnik faithfully using the natural resources of German, which could be termed a target-oriented approach. Yet they also write that they sometimes resorted to ingenious alternatives or “tricks” (“alternative Kunstgriffe”) to reproduce the “intensity” and “musicality” of the poems, which could point towards an adaptive approach. This article focuses on how they treated the semantic and stylistic content of Árbol de Diana in order to find out whether their approach reproduces the original effect or deviates from it.
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Amylin as a Future Obesity Treatment
Babak Dehestani,Nicholas RS Stratford,Carel W. le Roux 대한비만학회 2021 The Korean journal of obesity Vol.30 No.4
Obesity is defined as abnormal or excessive fat accumulation that contributes to detrimental health impacts. One-third of the population suffers from obesity, and it is important to consider obesity as a chronic disease requiring chronic treatment. Amylin is co-secreted with insulin from β pancreatic cells upon nutrient delivery to the small intestine as a satiety signal, acts upon sub-cortical homeostatic and hedonic brain regions, slows gastric emptying, and suppresses post-prandial glucagon responses to meals. Therefore, new pharmacological amylin analogues can be used as potential anti-obesity medications in individuals who are overweight or obese. In this narrative review, we analyse the efficacy, potency, and safety of amylin analogues. The synthetic amylin analogue pramlintide is an approved treatment for diabetes mellitus which promotes better glycaemic control and small but significant weight loss. AM833 (cagrilintide), an investigational novel long-acting acylated amylin analogue, acts as a non-selective amylin receptor. This calcitonin G protein-coupled receptor agonist can serve as an attractive novel treatment for obesity, resulting in reduction of food intake and significant weight loss in a dose-dependent manner.
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Dynamic assessment of a FRP suspension footbridge through field testing and finite element modelling
Renos A. Votsis,Tim J. Stratford,Marios K. Chryssanthopoulos,Elia A. Tantele 국제구조공학회 2017 Steel and Composite Structures, An International J Vol.23 No.2
The use of advanced fibre composite materials in bridge engineering offers alternative solutions to structural problems compared to traditional construction materials. Advanced composite or fibre reinforced polymer (FRP) materials have high strength to weight ratios, which can be especially beneficial where dead load or material handling considerations govern a design. However, the reduced weight and stiffness of FRP footbridges results in generally poorer dynamic performance, and vibration serviceability is likely to govern their design to avoid the footbridge being "too lively". This study investigates the dynamic behaviour of the 51.3 m span Wilcott FRP suspension footbridge. The assessment is performed through a combination of field testing and finite element analysis, and the measured performance of the bridge is being used to calibrate the model through an updating procedure. The resulting updated model allowed detailed interpretation of the results. It showed that non-structural members such as the parapets can influence the dynamic behaviour of slender, lightweight footbridges, and consequently their contribution must be included during the dynamic assessment of a structure. The test data showed that the FRP footbridge is prone to pedestrian induced vibrations, although the measured response levels were lower than limits specified in relevant standards.
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Moss, Jennifer,Tinline-Purvis, Helen,Walker, Carol A,Folkes, Lisa K,Stratford, Michael R,Hayles, Jacqueline,Hoe, Kwang-Lae,Kim, Dong-Uk,Park, Han-Oh,Kearsey, Stephen E,Fleck, Oliver,Holmberg, Christia Cold Spring Harbor Laboratory in association with 2010 Genes & development Vol.24 No.23
<P>Nucleotide synthesis is a universal response to DNA damage, but how this response facilitates DNA repair and cell survival is unclear. Here we establish a role for DNA damage-induced nucleotide synthesis in homologous recombination (HR) repair in fission yeast. Using a genetic screen, we found the Ddb1-Cul4(Cdt2) ubiquitin ligase complex and ribonucleotide reductase (RNR) to be required for HR repair of a DNA double-strand break (DSB). The Ddb1-Cul4(Cdt2) ubiquitin ligase complex is required for degradation of Spd1, an inhibitor of RNR in fission yeast. Accordingly, deleting spd1(+) suppressed the DNA damage sensitivity and the reduced HR efficiency associated with loss of ddb1(+) or cdt2(+). Furthermore, we demonstrate a role for nucleotide synthesis in postsynaptic gap filling of resected ssDNA ends during HR repair. Finally, we define a role for Rad3 (ATR) in nucleotide synthesis and HR through increasing Cdt2 nuclear levels in response to DNA damage. Our findings support a model in which break-induced Rad3 and Ddb1-Cul4(Cdt2) ubiquitin ligase-dependent Spd1 degradation and RNR activation promotes postsynaptic ssDNA gap filling during HR repair.</P>
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Glyceollin Transport, Metabolism, and Effects on P-Glycoprotein Function in Caco-2 Cells
Chukwuemezie Chimezie,Adina C. Ewing,Syeda S. Quadri,Richard B. Cole,Stephen M. Boue,Christopher F. Omari,Melyssa Bratton,Elena Glotser,Elena Skripnikova,Ian Townley,Robert E. Stratford 한국식품영양과학회 2014 Journal of medicinal food Vol.17 No.4
Glyceollins are phytoalexins produced in soybeans from their isoflavone precursor daidzein. Their impressive anticancer and glucose normalization effects in rodents have generated interest in their therapeutic potential. The aim of the present studies was to begin to understand glyceollin intestinal transport and metabolism, and their potential effects on P-glycoprotein (Pgp) in Caco-2 cells. At 10 and 25 lM, glyceollin permeability was 2.4 – 0.16 · 10- 4 cm/sec and 2.1 – 0.15 · 10- 4 cm/sec, respectively, in the absorptive direction. Basolateral to apical permeability at 25 lM was 1.6 – 0.10 · 10- 4 cm/sec. Results suggest high absorption potential of glyceollin by a passive-diffusion-dominated mechanism. A sulfate conjugate at the phenolic hydroxyl position was observed following exposure to Caco-2 cells. In contrast to verapamil inhibition of the net secretory permeability of rhodamine 123 (R123) and its enhancement of calcein AM uptake into Caco-2 cells, neither glyceollin nor genistein inhibited Pgp (MDR1; ABCB1) up to 300 lM. There was no significant change in MDR1 mRNA expression, Pgp protein expression, or R123 transport in cells exposed to glyceollin or genistein for 24 h up to 100 lM. Collectively, these results suggest that glyceollin has the potential to be well absorbed, but that, similar to the isoflavone genistein, its absorption may be reduced substantially by intestinal metabolism; further, they indicate that glyceollin does not appear to alter Pgp function in Caco-2 cells.
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