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RISS 인기검색어
- 검색키워드
- 저자 : Soleimanpour, Reza (검색결과 4 건)
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Survivin as a Potential Target for Cancer Therapy
Soleimanpour, Elaheh,Babaei, Esmaeil Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.15
In 1997 for the first time, survivin was described by Amborsini et al. as an anti-apoptotic protein. Subsequent studies revealed that survivin is a multifunctional protein that plays critical roles in several crucial cell processes such as apoptosis, cell cycle, chromosome movement, mitosis and cellular stress responses. Moreover, it's overexpression in cancer cells versus normal cells is associated with chemotherapy resistance, increased tumor recurrence, and shorter patient survival. All of these features make survivin a promising target for cancer therapy. Here, we review the potential characteristics of survivin as a tumor marker.
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Soleimanpour, Reza,Ng, Ching-Tai Techno-Press 2015 Structural monitoring and maintenance Vol.2 No.3
The paper presents an investigation into the mode conversion and scattering characteristics of guided waves at delaminations in laminated composite beams. A three-dimensional (3D) finite element (FE) model, which is experimentally verified using data measured by 3D scanning laser vibrometer, is used in the investigation. The study consists of two parts. The first part investigates the excitability of the fundamental anti-symmetric mode ($A_0$) of guided wave in laminated composite beams. It is found that there are some unique phenomena, which do not exist for guided waves in plate structures, make the analysis become more complicated. The phenomena are observed in numerical study using 3D FE simulations. In the second part, several delaminated composite beams are studied numerically to investigate the mode conversion and scattering characteristics of the $A_0$ guided wave at delaminations. Different sizes, locations and through-thickness locations of the delaminations are investigated in detail. The mode conversion and scattering phenomena of guided waves at the delaminations are studied by calculating reflection and transmission coefficients. The results show that the sizes, locations and through-thickness locations of the delaminations have significant effects on the scattering characteristics of guided waves at the delaminations. The results of this research would provide better understanding of guided waves propagation and scattering at the delaminations in the laminated composite beams, and improve the performance of guided wave damage detection methods.
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A baseline free method for locating imperfect bolted joints
Soleimanpour, Reza,Soleimani, Sayed Mohamad,Salem, Mariam Naser Sulaiman Techno-Press 2022 Structural monitoring and maintenance Vol.9 No.3
This paper studies detecting and locating loose bolts using nonlinear guided waves. The 3D Finite Element (FE) simulation is used for the prediction of guided waves' interactions with loose bolted joints. The numerical results are verified by experimentally obtained data. The study considers bolted joints consisting of two bolts. It is shown that the guided waves' interaction with surfaces of a loose bolted joint generates Contact Acoustic Nonlinearity (CAN). The study uses CAN for detecting and locating loose bolts. The processed experimentally obtained data show that the CAN is able to successfully detect and locate loose bolted joints. A 3D FE simulation scheme is developed and validated by experimentally obtained data. It is shown that FE can predict the propagation of guided waves in loose bolts and is also able to detect and locate them. Several numerical case studies with various bolt sizes are created and studied using the validated 3D FE simulation approach. It is shown that the FE simulation modeling approach and the signal processing scheme used in the current study are able to detect and locate the loose bolts in imperfect bolted joints. The outcomes of this research can provide better insights into understanding the interaction of guided waves with loose bolts. The results can also enhance the maintenance and repair of imperfect joints using the nonlinear guided waves technique.
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Saeid Reza Shahmoradi,Maryam Kabir Salmani,Hamid Reza Soleimanpour,Amir Hossein Tavakoli,Kazem Hosaini,Nooshin Haghighipour,Shahin Bonakdar 한국조직공학과 재생의학회 2019 조직공학과 재생의학 Vol.16 No.1
BACKGROUND: Articular cartilage damage is still a troublesome problem. Hence, several researches have been performed for cartilage repair. The aim of this study was to evaluate the chondrogenicity of demineralized bone matrix (DBM) scaffolds under cyclic hydrostatic pressure (CHP) in vitro. METHODS: In this study, CHP was applied to human bone marrow mesenchymal stem cells (hBMSCs) seeded on DBM scaffolds at a pressure of 5 MPa with a frequency of 0.5 Hz and 4 h per day for 1 week. Changes in chondrogenic and osteogenic gene expressions were analyzed by quantifying mRNA signal level of Sox9, collagen type I, collagen type II, aggrecan (ACAN), Osteocalcin, and Runx2. Histological analysis was carried out by hematoxylin and eosin, and Alcian blue staining. Moreover, DMMB and immunofluorescence staining were used for glycosaminoglycan (GAG) and collagen type II detection, respectively. RESULTS: Real-time PCR demonstrated that applying CHP to hBMSCs in DBM scaffolds increased mRNA levels by 1.3-fold, 1.2-fold, and 1.7-fold (p\0.005) for Sox9, Col2, and ACAN, respectively by day 21, whereas it decreased mRNA levels by 0.7-fold and 0.8-fold (p\0.05) for Runx2 and osteocalcin, respectively. Additionally, in the presence of TGF-b1 growth factor (10 ng/ml), CHP further increased mRNA levels for the mentioned genes (Sox9, Col2, and ACAN) by 1.4-fold, 1.3-fold and 2.5-fold (p\0.005), respectively. Furthermore, in histological assessment, it was observed that the extracellular matrix contained GAG and type II collagen in scaffolds under CHP and CHP with TGF-b1, respectively. CONCLUSION: The osteo-inductive DBM scaffolds showed chondrogenic characteristics under hydrostatic pressure. Our study can be a fundamental study for the use of DBM in articular cartilage defects in vivo and lead to production of novel scaffolds with two different characteristics to regenerate both bone and cartilage simultaneously.
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