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- 저자 : Sohag Abdullah Al Mamun (검색결과 2 건)
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Repositioning Vitamin C as a Promising Option to Alleviate Complications associated with COVID-19
Farjana Mithila,Moni Akhi,Sohag Abdullah Al Mamun,Hasan Adeba,Hannan Md. Abdul,Hossain Md. Golzar,UDDIN MD JAMAL 대한감염학회 2020 Infection and Chemotherapy Vol.52 No.4
Vitamin C, also known as L-ascorbic acid, is an essential vitamin with pleiotropic functions, ranging from antioxidant to anti-microbial functions. Evidence suggests that vitamin C acts against inflammation, oxidative stress, autophagy chaos, and immune dysfunction. The ability to activate and enhance the immune system makes this versatile vitamin a prospective therapeutic agent amid the current situation of coronavirus disease 2019 (COVID-19). Being highly effective against the influenza virus, causing the common cold, vitamin C may also function against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and its associated complications. Severe infections need higher doses of the vitamin to compensate for the augmented inflammatory response and metabolic demand that commonly occur during COVID-19. Compelling evidence also suggests that a high dose of vitamin C (1.5 g/kg body weight) in inflammatory conditions can result in effective clinical outcomes and thus can be employed to combat COVID-19. However, further studies are crucial to delineate the mechanism underlying the action of vitamin C against COVID-19. The current review aims to reposition vitamin C as an alternative approach for alleviating COVID-19-associated complications.
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Tahjib-Ul-Arif,Popy Rani Roy,Abdullah Al Mamun Sohag,Sonya Afrin,Mostafa M Rady,M. Afzal Hossain 한국작물학회 2018 Journal of crop science and biotechnology Vol.21 No.4
Salinity is one of the most brutal abiotic stressors, commencing a great stumbling block in the way of attaining food security in Bangladesh. Cultivation of rice in saline soils can be possible after enhancing its salt tolerance. This study aimed to examine the potential impact of exogenous calcium (3 and 5 mM Ca2+ in CaCl2) on conferring salt tolerance in rice (cv. BRRI dhan28). At the germination stage, Ca2+-primed seeds were grown under 100 mM NaCl stress conditions for nine days. At the seedling stage, rice seedlings were grown in a sandponic culture with Hoagland′s nutrient solution amended or not amended with 100 mM NaCl for 20 days with or without Ca2+ supplementation. Our results revealed that NaCl-stressed rice plants showed highly compromised germination indices and growth parameters, which could be attributed to reduced shoot and root growth, decreased photosynthetic pigments, increased H2O2 accumulation, and elevated levels of lipid peroxidation measured as malondialdehyde (MDA). On the other hand, exogenous Ca2+ application noticeably improved germination indices, growth and biomass-related parameters under salt stress. Ca2+-treated salt-stressed plants displayed amplified chlorophyll content, as well as suppressed the accumulation of H2O2, contributing to oxidative damage protection. Ca2+ supplementation for salt-stressed rice seedlings elevated relative water content without increasing excess proline, indicating the role of Ca2+ in maintaining water balance under stressful conditions. Furthermore, exogenous Ca2+ decreased membrane injury under NaCl stress, as mirrored by notably diminished levels of MDA in stressed seedlings. The defensive role of Ca2+ counter to oxidative stress was connected with the elevated activities of antioxidant enzymes such as catalase, ascorbate peroxidase, and peroxidase. In general, the best results in terms of growth at both germination and seedling stages were obtained in response to 3 mM Ca2+ treatment. Finally, Ca2+ supplementation can be an effective practice to cultivate rice in saline soils.
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