The earth mover’s distance and Bayesian linear discriminant analysis for epileptic seizure detection in scalp EEG

Shasha Yuan,Jinxing Liu,Junliang Shang,Xiangzhen Kong,Qi Yuan,Zhen Ma 대한의용생체공학회 2018 Biomedical Engineering Letters (BMEL) Vol.8 No.4

Since epileptic seizure is unpredictable and paroxysmal, an automatic system for seizure detecting could be of greatsignificance and assistance to patients and medical staff. In this paper, a novel method is proposed for multichannel patientspecificseizure detection applying the earth mover’s distance (EMD) in scalp EEG. Firstly, the wavelet decomposition isexecuted to the original EEGs with five scales, the scale 3, 4 and 5 are selected and transformed into histograms andafterwards the distances between histograms in pairs are computed applying the earth mover’s distance as effectivefeatures. Then, the EMD features are sent to the classifier based on the Bayesian linear discriminant analysis (BLDA) forclassification, and an efficient postprocessing procedure is applied to improve the detection system precision, finally. Toevaluate the performance of the proposed method, the CHB-MIT scalp EEG database with 958 h EEG recordings from 23epileptic patients is used and a relatively satisfactory detection rate is achieved with the average sensitivity of 95.65% andfalse detection rate of 0.68/h. The good performance of this algorithm indicates the potential application for seizuremonitoring in clinical practice.

Gradient folding metasurfaces with simultaneous phase and amplitude modulation

Zibin Lin,Weikai Xu,Wei Wang,Shasha Yuan 대한기계학회 2021 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.35 No.12

An elastic metasurface with a gradient index of functional units, namely gradient folding metasurface (GFMS), is proposed to simultaneously manipulate the transmission phase and amplitude of flexural waves. By varying the gradient index common ratio (CR) between each adjacent unit, the GFMS was found to cover an entire 2π span of phase shift. At the same time, the amplitude of the transmitted flexural wave can also be modulated. Based on the generalized Snell's law, two different cases of the wave focusing effect are realized, which illustrate CR dependent wave propagation mode from symmetric to asymmetric and verify the ability of the proposed metasurface to manipulate complete elastic wave through simultaneous phase and amplitude modulation. This study expands phase-amplitude modulation from acoustics to elastic waves and provides more degrees of freedom in elastic metasurface designing.

Catalytic topological insulator Bi₂Se₃ nanoparticles for <i>in</i> <i>vivo</i> protection against ionizing radiation

Zhang, Xiao-Dong,Jing, Yaqi,Song, Shasha,Yang, Jiang,Wang, Jun-Ying,Xue, Xuhui,Min, Yuho,Park, Gyeongbae,Shen, Xiu,Sun, Yuan-Ming,Jeong, Unyong Elsevier 2017 Nanomedicine Vol.13 No.5

<P><B>Abstract</B></P> <P>Bi<SUB>2</SUB>Se<SUB>3</SUB> nanoparticles (NPs) have attracted wide interests in biological and medical applications. Layer-like Bi<SUB>2</SUB>Se<SUB>3</SUB> with high active surface area is promising for free radical scavenging. Here, we extended the medical applications of Bi<SUB>2</SUB>Se<SUB>3</SUB> NPs further to <I>in vivo</I> protection against ionizing radiation based on their superior antioxidant activities and electrocatalytic properties. It was found that Bi<SUB>2</SUB>Se<SUB>3</SUB> NPs can significantly increase the surviving fraction of mice after exposure of high-energy radiation of gamma ray. Additionally, the Bi<SUB>2</SUB>Se<SUB>3</SUB> NPs can help to recover radiation-lowered red blood cell counts, white blood cell counts and platelet levels. Further investigations revealed that Bi<SUB>2</SUB>Se<SUB>3</SUB> NPs behaved as functional free radical scavengers and significantly decreased the level of methylenedioxyamphetamine. <I>In vivo</I> toxicity studies showed that Bi<SUB>2</SUB>Se<SUB>3</SUB> NPs did not cause significant side effects in panels of blood chemistry, clinical biochemistry and pathology.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Bi<SUB>2</SUB>Se<SUB>3</SUB> NPs can significantly increase the surviving fraction of mice up to 70% after Gamma radiation. </LI> <LI> Bi<SUB>2</SUB>Se<SUB>3</SUB> NPs can help to recover radiation-lowered red blood cell counts, white blood cell counts and platelet levels. </LI> <LI> Bi<SUB>2</SUB>Se<SUB>3</SUB> NPs behaved as functional free radical scavengers and significantly decreased the level of methylenedioxyamphetamine. </LI> </UL> </P> <P><B>Graphical Abstract</B></P> <P>Layer-like Bi<SUB>2</SUB>Se<SUB>3</SUB> with high active surface area can protect mice against ionizing radiation based on their superior antioxidant activities and electrocatalytic properties. Bi<SUB>2</SUB>Se<SUB>3</SUB> NPs can significantly increase the surviving fraction of mice up to 70% after exposure of high-energy radiation of gamma ray. Bi<SUB>2</SUB>Se<SUB>3</SUB> NPs behaved as functional free radical scavengers and significantly decreased the level of methylenedioxyamphetamine. <I>In vivo</I> toxicity studies showed that Bi<SUB>2</SUB>Se<SUB>3</SUB> NPs did not cause significant side effects in panels of blood chemistry, clinical biochemistry and pathology.</P> <P>[DISPLAY OMISSION]</P>

MicroRNA analysis reveals the role of miR-214 in duck adipocyte differentiation

Wang Laidi,Hu Xiaodan,Wang Shasha,Yuan Chunyou,Wang Zhixiu,Chang Guobin,Chen Guohong 아세아·태평양축산학회 2022 Animal Bioscience Vol.35 No.9

Objective: Fat deposition in poultry is an important factor in production performance and meat quality research. miRNAs also play important roles in regulating adipocyte differentiation process. This study was to investigate the expression patterns of miRNAs in duck adipocytes after differentiation and explore the role of miR-214 in regulating carnitine palmitoyltransferases 2 (CPT2) gene expression during duck adipocyte differentiation. Methods: Successful systems for the isolation, culture, and induction of duck primary fat cells was developed in the experiment. Using Illumina next-generation sequencing, the miRNAs libraries of duck adipocytes were established. miRanda was used to predict differentially expressed (DE) miRNAs and their target genes. The expression patterns of miR-214 and CPT2 during the differentiation were verified by quantitative real-time polymerase chain reaction and western blot. Luciferase reporter assays were used to explore the specific regions of CPT2 targeted by miR-214. We used a miR-214 over-expression strategy in vitro to further investigate its effect on differentiation process and CPT2 gene transcription. Results: There were 481 miRNAs identified in duck adipocytes, included 57 DE miRNA candidates. And the 1,046 targets genes of DE miRNAs were mainly involved in p53 signaling, FoxO signaling, and fatty acid metabolism pathways. miR-214 and CPT2 showed contrasting expression patterns before and after differentiation, and they were selected for further research. The expression of miR-214 was decreased during the first 3 days of duck adipocytes differentiation, and then increased, while the expression of CPT2 increased both in the transcriptional and protein level. The luciferase assay suggested that miR-214 targets the 3’untranslated region of CPT2. Overexpression of miR-214 not only promoted the formation of lipid droplets but also decreased the protein abundance of CPT2. Conclusion: Current study reports the expression profile of miRNAs in duck adipocytes differentiated for 4 days. And miR-214 has been proved to have the regulator potential for fat deposition in duck. Objective: Fat deposition in poultry is an important factor in production performance and meat quality research. miRNAs also play important roles in regulating adipocyte differentiation process. This study was to investigate the expression patterns of miRNAs in duck adipocytes after differentiation and explore the role of miR-214 in regulating carnitine palmitoyltransferases 2 (CPT2) gene expression during duck adipocyte differentiation.Methods: Successful systems for the isolation, culture, and induction of duck primary fat cells was developed in the experiment. Using Illumina next-generation sequencing, the miRNAs libraries of duck adipocytes were established. miRanda was used to predict differentially expressed (DE) miRNAs and their target genes. The expression patterns of miR-214 and CPT2 during the differentiation were verified by quantitative real-time polymerase chain reaction and western blot. Luciferase reporter assays were used to explore the specific regions of CPT2 targeted by miR-214. We used a miR-214 over-expression strategy in vitro to further investigate its effect on differentiation process and CPT2 gene transcription.Results: There were 481 miRNAs identified in duck adipocytes, included 57 DE miRNA candidates. And the 1,046 targets genes of DE miRNAs were mainly involved in p53 signaling, FoxO signaling, and fatty acid metabolism pathways. miR-214 and CPT2 showed contrasting expression patterns before and after differentiation, and they were selected for further research. The expression of miR-214 was decreased during the first 3 days of duck adipocytes differentiation, and then increased, while the expression of CPT2 increased both in the transcriptional and protein level. The luciferase assay suggested that miR-214 targets the 3’untranslated region of CPT2. Overexpression of miR-214 not only promoted the formation of lipid droplets but also decreased the protein abundance of CPT2.Conclusion: Current study reports the expression profile of miRNAs in duck adipocytes differentiated for 4 days. And miR-214 has been proved to have the regulator potential for fat deposition in duck.

3-D Deformation Behavior Simulation of Cable Stitch Based on Particle System in Weft Knitted Fabrics

Sha Sha,Lei Luo,Zhongmin Deng,Dapeng Yuan,Bin Li,Xuewei Jiang,Hui Tao,Qufu Wei 한국섬유공학회 2018 Fibers and polymers Vol.19 No.9

The static simulation of weft knitting can be efficiently realized by graphics simulation techniques, but there still remains a challenge for mechanical models. The lack of practical mechanical models significantly limit the realistic deformation behaviors of complex cable stitches, which lead to a great different between the simulation effect and the actual fabric. In order to obtain the deformation behavior and volumetric performance of cable stitch, loop models were built based on an improved particle system in this work. Compared with plain weft knitted, the offset value of bonding points of cable stitches were measured. By analyzing the relationship between the deformation of loops and the displacement of the particles, the deformation behavior of cable stitch was simulated. Velocity-Verlet integration was introduced to simulate cable stitches and the stable results were obtained. The results show that these models and algorithm displayed the accurate deformation behavior of cable stitches, as demonstrated by qualitative comparisons to measure the deformations of actual samples.