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Seo, Seunghwan,Shin, Ji-Sun,Lee, Woo-Seok,Rhee, Young Kyoung,Cho, Chang-Won,Hong, Hee-Do,Lee, Kyung-Tae Elsevier 2017 Journal of Functional Foods Vol.29 No.-
<P><B>Abstract</B></P> <P>Lactobacillus strains are used in the functional food industry as promising probiotics with purported beneficial effects. We recently reported on the immunostimulatory effects of <I>Lactobacillus sakei</I> K040706 (K040706) in macrophages and in a cyclophosphamide-induced immunosuppression model. And this study assessed the anti-inflammatory effects and molecular mechanisms involving K040706 in a mouse model of colitis with dextran sodium sulfate (DSS). K040706 significantly attenuated the clinical signs and histological characteristics in DSS-induced colitic mice, which are well-correlated with the restoration of tight junction protein expression and the significant reduction of immune cell infiltration and expression of ICAM-1 and VCAM-1. Moreover, K040706 reduced the abnormal expression of pro-inflammatory mediators, such as iNOS, TNF-α, IL-1β, and IL-6, and the activation of NF-κB, STAT3 and TLR4. K040706 also improved the composition of intestinal microbiota. These results suggest K040706 has shown significant anti-inflammatory effects in a DSS-induced colitis model and has the potential to treat IBD.</P> <P><B>Highlights</B></P> <P> <UL> <LI> K040706 attenuated DSS-induced colitis severity and epithelial injury. </LI> <LI> K040706 suppressed the DSS-induced expression of pro-inflammatory mediators. </LI> <LI> K040706 downregulated the DSS-induced activation of TLR4/NF-κB/STAT3 signaling. </LI> <LI> K040706 improved the intestinal microbiota composition. </LI> <LI> K040706 has potential as a treatment option for inflammatory bowel disease. </LI> </UL> </P>