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안미정,허승담,지영흔,주홍구,이용덕,심기범,신태균,Ahn, Mee-jung,Heo, Seung-dam,Jee, Young-heun,Joo, Hong-gu,Lee, Yong-duk,Sim, Ki-Bum,Shin, Tae-kyun The Korean Society of Veterinary Science 2003 大韓獸醫學會誌 Vol.43 No.4
The phosphorylation of extracellular signal-regulated kinases (p-ERK) in the spinal cord of rats with acute monophasic experimental autoimmune encephalomyelitis (EAE) was studied using immunohistochemistry and treatment with inhibitor. P-ERK is constitutively expressed in glial cells in the normal spinal cord. In EAE, some inflammatory cells in the subarachnoid space were positive for p-ERK at the early stage, and its immunoreactivity declined when those cells infiltrated the parenchyma at the peak stage. In a blocking experiment using its inhibitor, the intravenous administration of PD98059 from day 7 to 13 post-immunization did not modulate EAE paralysis. Considering the results, we postulate that intravenous administration of PD98059 is not effective in ameliorating EAE paralysis, although many inflammatory cells express ERK in the subarachnoid space.