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Levada Kateryna,Pshenichnikov Stanislav,Omelyanchik Alexander,Rodionova Valeria,Nikitin Aleksey,Savchenko Alexander,Schetinin Igor,Zhukov Dmitry,Abakumov Maxim,Majouga Alexander,Lunova Mariia,Jirsa Mi 나노기술연구협의회 2020 Nano Convergence Vol.7 No.17
Iron oxide nanoparticles (IONs) are frequently used in various biomedical applications, in particular as magnetic resonance imaging contrast agents in liver imaging. Indeed, number of IONs have been withdrawn due to their poor clinical performance. Yet comprehensive understanding of their interactions with hepatocytes remains relatively limited. Here we investigated how iron oxide nanocubes (IO-cubes) and clusters of nanocubes (IO-clusters) affect distinct human hepatic cell lines. The viability of HepG2, Huh7 and Alexander cells was concentration-dependently decreased after exposure to either IO-cubes or IO-clusters. We found similar cytotoxicity levels in three cell lines triggered by both nanoparticle formulations. Our data indicate that different expression levels of Bcl-2 predispose cell death signaling mediated by nanoparticles. Both nanoparticles induced rather apoptosis than autophagy in HepG2. Contrary, IO-cubes and IO-clusters trigger distinct cell death signaling events in Alexander and Huh7 cells. Our data clarifies the mechanism by which cubic nanoparticles induce autophagic flux and the mechanism of subsequent toxicity. These findings imply that the cytotoxicity of ION-based contrast agents should be carefully considered, particularly in patients with liver diseases.
" Multineuron " Neural Simulator and Its Medical Applications
Alexander N. Gorban,S. E. Gliev,D. A. Kochenov,Ye. M. Mirkes,S. E. Golovenkin,S. A. Dogadin,K. G. Nazdrachev,E. V. Maslennikova,G. V. Matyushin,D. A. Rossiev,V. A. Shulman,A. A. Savchenko 대한전자공학회 1994 ICONIP : International Conference On Neural Inform Vol.3 No.1
Boronated Porphyrins and Chlorins as Potential Anticancer Drugs
Ol'shevskaya, Valentina A.,Zaytsev, Andrey V.,Savchenko, Arina N.,Shtil, Alexander A.,Cheong, Chan-Seong,Kalinin, Valery N. Korean Chemical Society 2007 Bulletin of the Korean Chemical Society Vol.28 No.11
Analyzed are recent advances in design of novel boronared conjugates of synthetic and natural porphyrins and chlorins. These compounds showed high efficacy as cytotoxic agents for tumor cells in culture and as phototoxins in photodynamic therapy of tumor xenografts. Thus, boronated porphyrins and chlorins emerge as promising class of anticancer agents with potentially multiple advantages: the chemotherapeutic drugs alone and photo- and radiosensitizers in binary treatments.
Boronated Porphyrins and Chlorins as Potential Anticancer Drugs
Valentina A. Ol'shevskaya,Andrey V. Zaytsev,Arina N. Savchenko,Alexander A. Shtil,정찬성,Valery N. Kalinin* 대한화학회 2007 Bulletin of the Korean Chemical Society Vol.28 No.11
Analyzed are recent advances in design of novel boronared conjugates of synthetic and natural porphyrins and chlorins. These compounds showed high efficacy as cytotoxic agents for tumor cells in culture and as phototoxins in photodynamic therapy of tumor xenografts. Thus, boronated porphyrins and chlorins emerge as promising class of anticancer agents with potentially multiple advantages: the chemotherapeutic drugs alone and photo- and radiosensitizers in binary treatments.