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Boronated Porphyrins and Chlorins as Potential Anticancer Drugs
Ol'shevskaya, Valentina A.,Zaytsev, Andrey V.,Savchenko, Arina N.,Shtil, Alexander A.,Cheong, Chan-Seong,Kalinin, Valery N. Korean Chemical Society 2007 Bulletin of the Korean Chemical Society Vol.28 No.11
Analyzed are recent advances in design of novel boronared conjugates of synthetic and natural porphyrins and chlorins. These compounds showed high efficacy as cytotoxic agents for tumor cells in culture and as phototoxins in photodynamic therapy of tumor xenografts. Thus, boronated porphyrins and chlorins emerge as promising class of anticancer agents with potentially multiple advantages: the chemotherapeutic drugs alone and photo- and radiosensitizers in binary treatments.
Boronated Porphyrins and Chlorins as Potential Anticancer Drugs
Valentina A. Ol'shevskaya,Andrey V. Zaytsev,Arina N. Savchenko,Alexander A. Shtil,정찬성,Valery N. Kalinin* 대한화학회 2007 Bulletin of the Korean Chemical Society Vol.28 No.11
Analyzed are recent advances in design of novel boronared conjugates of synthetic and natural porphyrins and chlorins. These compounds showed high efficacy as cytotoxic agents for tumor cells in culture and as phototoxins in photodynamic therapy of tumor xenografts. Thus, boronated porphyrins and chlorins emerge as promising class of anticancer agents with potentially multiple advantages: the chemotherapeutic drugs alone and photo- and radiosensitizers in binary treatments.