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- 저자 : Sanghera (검색결과 2 건)
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Infrared Scanning Near-Field Optical Microscopy (IR-SNOM) Below the Diffraction Limit
J,S,Sanghera,I,D,Aggarwal,A,Cricenti,R,Generossi,M,Luce,P,Perfetti,G,Margoritondo,N,Tolk,D,Piston 한국세라믹학회 2007 세라미스트 Vol.10 No.3
Infrared Scanning Near-field Optical Microscopy (IR-SNOM) is an extremely powerful analytical instrument since it combines IR spectroscopy’s high chemical specificity with SNOM’s high spatial resolution. In order to do this in the infrared, specialty chalcogenide glass fibers were fabricated and their ends tapered to generate SNOM probes. The fiber tips were installed in a modified near field microscope and both inorganic and biological samples illuminated with the tunable output from a free-electron laser located at Vanderbilt University. Both topographical and IR spectral images were simultaneously recorded with a resolution of ~50 nm and ~100 nm, respectively. Unique spectroscopic features were identified in all samples, with spectral images exhibiting resolutions of up to μ60, or at least 30 times better than the diffraction limited lens-based microscopes. We believe that IR-SNOM can provide a very powerful insight into some of the most important bio-medical research topics.
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Biomarker for Ischemic Stroke Using Metabolome: A Clinician Perspective
Evgeny Sidorov,Dharambir K. Sanghera,Jairam K. P. Vanamala 대한뇌졸중학회 2019 Journal of stroke Vol.21 No.1
Finding ischemic stroke biomarker is highly desirable because it can improve diagnosis even before a patient arrives to the hospital. Metabolome is one of new technologies that help to find biomarkers. Most metabolome-related ischemic stroke studies were done in Asia and had exploratory designs. Although failed to find specific biomarkers, they discovered several important metabolite-stroke associations which belong to three pathophysiological mechanisms: Excitotoxicity with activation of glutamate, resulting in the increase of glutamate derivatives proline and pyroglutamate; Oxidative stress with production of free radicals and perturbed concentrations of uric acid, matrix metalloproteinase-9, branch-chained amino acids, sphingolipids, homocysteine, asymmetric dimethylarginine, nitric oxide and folate cycle metabolites; and Stroke mediated inflammation, affecting phospholipid metabolism with perturbed levels of lysophosphatidylethanolamine and lysophosphatidylcholine. The discovered metabolite-stroke associations need further evaluation in prospective, high-quality studies with patients matched for age, risk factors, and medications.
ScienceON
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