안면거상술시의 하악각 교정

조성태,황귀환,차동섭 大韓成形外科學會 1999 Archives of Plastic Surgery Vol.26 No.3

Many people want to receive facial rejuvenation with surgical treatment, but the post operative result is not always satisfying following classic soft tissue surgery. The reasons for dissatisfaction are many. We were particularly interested in the skeletal disharmony which is frequent in orientals. Since many orientals have flat and quadrangular facial contours, they often don't obtain the harmony of the facial skeleton and soft tissue despite successful surgery. So, to correct facial contour, mandibular angle contouring can be performed at the time of face lift. Seven patients had mandibular angle resection performed during facial rhytidectomy from October of 1996 to October of 1998 at Kangbuk Samsung Hospital, and they were followed from 4 months to 24 months. At the time of face lift, we tried the retromandibular approach for mandibular angle resection when it was indicated, instead of the intraoral approach which does not leave a noticeable scar and does not have the risk of facial nerve injury. Because of a restricted operative field, the intraoral approach has the disadvantages of a long operation time and a high risk of complications. The retromandibular approach with rhytidectomy incision showed neither noticeable scar nor developed a facial nerve injury. In conclusion, we found that mandibular angle contouring by retromandibular approach is easy and the result is more normal with a shorter recovery time. There were no complications and aesthetic results were quite satisfactory.

Physiologically based pharmacokinetic (PBPK) modeling of fl urbiprofen in different CYP2C9 genotypes

Sang-Sup Whang,Chang-Keun Cho,Eui Hyun Jung,Pureum Kang,Hye-Jung Park,Yun Jeong Lee,Chang-Ik Choi,Jung-Woo Bae,Hyung Sik Kim,Choon-Gon Jang,Seok-Yong Lee 대한약학회 2022 Archives of Pharmacal Research Vol.45 No.8

The aim of this study was to establish the physiologicallybased pharmacokinetic (PBPK) model of fl urbiprofenrelated to CYP2C9 genetic polymorphism anddescribe the pharmacokinetics of fl urbiprofen in diff erentCYP2C9 genotypes. PK-Sim® software was used for themodel development and validation. A total of 16 clinicalpharmacokinetic data for fl urbiprofen in diff erent CYP2C9genotypes, dose regimens, and age groups were used for thePBPK modeling. Turnover number (k cat ) of CYP2C9 valueswere optimized to capture the observed profi les in diff erentCYP2C9 genotypes. In the simulation, predicted fractionmetabolized by CYP2C9, fraction excreted to urine, bioavailability,and volume of distribution were similar to previouslyreported values. Predicted plasma concentration-timeprofi les in diff erent CYP2C9 genotypes were visually similarto the observed profi les. Predicted AUC inf in CYP2C9*1/*2 ,CYP2C9*1/*3 , and CYP2C9*3/*3 genotypes were 1.44-,2.05-, and 3.67-fold higher than the CYP2C9*1/*1 genotype. The ranges of fold errors for AUC inf , C max , and t 1/2 were 0.84–1.00, 0.61–1.22, and 0.74–0.94 in development and0.59–0.98, 0.52–0.97, and 0.61–1.52 in validation, respectively,which were within the acceptance criterion. Thus, thePBPK model was successfully established and described thepharmacokinetics of fl urbiprofen in diff erent CYP2C9 genotypes,dose regimens, and age groups. The present modelcould guide the decision-making of tailored drug administrationstrategy by predicting the pharmacokinetics of fl urbiprofenin various clinical scenarios.

멀티미디어 매체의 특성과 학습 효과에 대한 탐색적 연구

황상민 ( Sang Min Whang ),김성일 ( Sung Il Kim ),김소영 ( So Young Kim ),변은희 ( Eun Hee Byun ),이재호 ( Jae Ho Lee ),조광수 ( Kwang Soo Cho ),최상섭 ( Sang Sup Choi ),이정모 ( Jung Mo Lee ) 한국교육공학회 1998 교육공학연구 Vol.14 No.2

Studies on the Effect of Priming Treatment on the Germination of Sesame (Sesamum indicum L.)

Sang Kyun Cho,Kang Bo Shim,YU Yuoung Lee,Jac Duck Scong,Jeong Dong Whang,Young Sup Ahn,Duck Yong Suh 한국육종학회 2005 한국육종학회 학술발표회 발표요지 Vol.37 No.1

Venous Anastomosis with Dorsal Veins Using Additional Incisions after Wound Closure in Metacarpophalangeal Joint Level Replantation

Cho, Sang Hyun,Bahar-Moni, Ahmed Suparno,Whang, Jong Ick,Seo, Hyeung Gyo,Park, Hyun Sik,Kim, Ji Sup,Park, Hyun Chul The Korean Society for Microsurgery 2016 Archives of reconstructive microsurgery Vol.25 No.1

In cases of replantation, accurate closure of all structures, including bone, tendons, arteries, nerves, and veins is essential. Among these, the vein is a weaker structure and is damaged severely in most amputation cases. After fixation of bone, repair of tendons, nerves, and arteries, surgeons often experience difficulty in performing venous anastomoses. We found that in such cases, venous anastomosis is easy to perform using an additional incision after closure of the original wound. In a 33-year-old male patient with amputation of all four fingers at the metacarpophalangeal joint level, venous anastomoses were performed with dorsal veins using additional incisions after completion of the fixation of bones and repair of all other structures and closure of the skin due to surgical site tension.

액취증에 관한 임상적 고찰

조성태,백인구,황귀환,임동훈,차동섭 大韓成形外科學會 1997 Archives of Plastic Surgery Vol.24 No.5

Axillary osmidrosis is caused by excessive apocrine secretion with acrid odor and causes extreme social embarassement. We reviewed and evaluated the results of the treatment of 86 % osmidrosis axillae patients (172 cases), who were treated in Kangbuk Samsung hospital from 1994 to 1996. The following results were obtained. 1. Manual method is considered to be superior to Inaba's method in terms of reverence, hematoma and tissue necrosis. 2. Prevalence rate of hematoma is reversely related to the age of patients and this may be due to inadequate cooperation of young patients. 3. Prevalence rate of tissue necrosis tends to decrease according to the earlier detection of hematoma. 4. Flap thickness has no relation with complication and recurrence. We have carried out comparative study of surgical method employed today in aspects of complication and recurrence rate and hereby resort that our study result can provide better clinical outcomes.

Candidate of Probiotic Bacteria Isolated from Several Jeotgals: Korean Traditional Fermented Seafoods

Gyu Sung Cho,Hyung Ki Do,Chae Yoon Bae,Gyu Sup Cho,Cher Won Whang,Heuyn Kil Shin 한국식품영양과학회 2006 Preventive Nutrition and Food Science Vol.11 No.2

Seventy eight bacterial strains were isolated from several jeotgals using MRS and M 17 agar media. The probiotic properties such as tolerance of extreme growth condition, production of antimicrobial compound, production of hydrogen peroxide, and enzymatic activity of bile salt hydrolase were investigated. DHK 4, 10, 21 and 74 strains showed a strong tolerance property against extreme conditions such as low pH and 0.5% oxgall-supplemented medium. DHK 10 and 47 strains produced hydrogen peroxide on TMB agar plate. DHK 8 and 10 strains produced antimicrobial compounds onto MRS agar against E. facalis. DHK 4, 6, 21, 29, 33, 63 and 87 strains had high activities of bile salt hydrolase. Especially, DHK 10 displayed a strong probiotic candidate; the abilities to produce the antimicrobial compound, hydrogen peroxide, and bile salt hydrolase. All these strains are assumed to be useful probiotic candidates. Among 78, twenty seven strains which have probiotic properties were tentatively identified by 16S rRNA sequencing. Among them, 7 Lactobacillus spp., 6 Leuconosotoc spp., 2 Weisella spp., 1 Pediococcus sp., 1 Staphylococcus sp., 1 Enterococcus sp. and 2 Streptococcus spp. were tentatively identified.

Mirizzi 증후군

조성원(Sung Won Cho),심찬섭(Chan Sup Shim),황효주(Hyo Joo Whang),함승원(Seung Won Ham),조종근(Jong Geun Cho),김익수(Ik Soo Kim) 대한소화기학회 1987 대한소화기학회지 Vol.19 No.2

Mirizzi syndrome is obstruction of the common hepatic duct secondary to pressure from an impacted stone, either in the cystic duct or the neck of the gallbladder. We experienced of a 61-year-old female patient, whose clinical symptoms v:ere progressive jaun- dice, loss of appetite, pain on right upper quadrant abdomen, and fever with chill and ultrasonogram and ERCP revealed dilatation of common hepatic duct and intrahepatic duct with impacted stone on lateral wall of common hepatic duct.

계층 그리드 화일을 이용한 선택률의 추정

김상욱(Sang-Wook Kim),조완섭(Wan-Sup Cho),황규영(Kyu-Young Whang) 한국정보과학회 1991 한국정보과학회 학술발표논문집 Vol.18 No.2

선택률(selectivity)의 정확한 추정은 질의최적화 과정 및 물리적 데이타베이스 설계시의 필수적인 요소가 된다. 본 연구에서는 시스템에 저장된 튜플의 분포를 고려하여 보다 정확하게 선택률을 추정할 수 있는 새로운 선택률 추정기법을 제안한다. 제안된 기법에서는 튜플의 분포정보를 저장하는 자료구조로서 다차원 동적 해쉬 화일구조(multidimensional dynamic hashed file structure)의 하나인 계층 그리드 화일(Multilevel Grid file)을 이용한다. 본 논문에서는 먼저 계층 그리드 화일의 각 단계 디렉토리가 시스템에 저장된 튜플의 분포를 반영한다는 것을 밝히고, 이를 기반으로 선택률을 추정하는 기법을 제안한다. 계층 그리드 화일은 삽입과 삭제가 빈번히 발생되는 동적인 환경에서도 튜플의 분포를 지속적으로 유지할 수 있다. 따라서 제안된 기법에서는 히스토그램(histogram) 기법과 같은 기존의 정적인 기법의 문제점인 재구성의 오버헤드를 해결할 수 있다는 것이 가장 큰 장점이다.

주문형 비디오 시스템에서의 동적 버퍼 할당 기법

이상호(Sang-Ho Lee),문양세(Yang-Sae Moon),황규영(Kyu-Young Whang),조완섭(Wan-Sup Cho) 한국정보과학회 2001 정보과학회논문지 : 시스템 및 이론 Vol.28 No.9·10

주문형 비디오 시스템에서 초기대기시간과 메모리 요구량의 최소화는 중요하다. 초기대기시간의 최소화는 빠른 응답 시간의 서비스를 제공할 수 있게 하고, 메모리 요구량의 최소화는 동일한 메모리량으로 더 많은 동시 사용자 요청을 서비스할 수 있게 한다. 주문형 비디오 시스템에서는 사용자 요청에게 할당되는 버퍼의 크기가 증가함에 따라 초기대기시간과 메모리 요구량이 증가하므로 사용자 요청에게 할당되는 버퍼의 크기를 최소화해야 한다. 그러나, 기존의 정적 버퍼 할당 기법은 시스템이 완전 부하된 상태에 있다는 가정하에서 버퍼 크기를 결정하여 시스템이 불완전 부하인 경우에는 사용자 요청에게 필요 이상으로 큰 버퍼를 할당한다. 본 논문에서는 시스템의 완전 부하 상태 뿐만 아니라 불완전 부하 상태에서도 사용자 요청에게 최소 크기의 버퍼를 할당하는 동적 버퍼 할당 기법을 제안한다. 동적 버퍼 할당 기법은 서비스 중인 사용자 요청 수와 이들 요청들을 서비스하는 동안에 도착하는 사용자 요청 수에 기반하여 버퍼 크기를 동적으로 결정한다. 또한, 분석과 시뮬레이션을 통하여 동적 버퍼 할당 기법이 초기대기시간과 지원 가능한 동시 사용자 요청 수에 있어서 정적 버퍼 할당 기법에 비해 크게 우수함을 보인다. 시뮬레이션 결과, 동적 버퍼 할당 기법이 정적 버퍼 할당 기법에 비해 평균 초기대기시간을 29% ~ 65% 줄이고, 다수의 디스크들로 구성된 시스템에서는 서비스한 평균 동시 사용자 요청 수를 48% ~ 68% 증가시킨 것으로 나타났다. 이와 같은 결과는 동적 버퍼 할당 기법이 주문형 비디오 시스템의 성능과 용량을 크게 향상시킴을 보여주는 것이다. In video-on-demand (VOD) systems it is important to minimize initial latency and memory requirements. The minimization of initial latency enables the system to provide services with short response time, and the minimization of memory requirements enables the system to service more concurrent user requests with the same amount of memory. In VOD systems, since initial latency and memory requirement increase according to the increment of buffer size allocated to user requests, the buffer size allocated to user requests must be minimized. The existing static buffer allocation scheme, however, determines the buffer size based on the assumption that the system is in the fully loaded state. Thus, when the system is in a partially loaded state, the scheme allocates user requests unnecessarily large buffers. This paper proposes a dynamic buffer allocation scheme that allocates user requests the minimum buffer size in the fully loaded state as well as a partially loaded state. This scheme dynamically determines the buffer size based on the number of user requests in service and the number of user requests arriving while servicing current requests. In addition, through analyses and simulations, this paper validates that the dynamic buffer allocation outperforms the static buffer allocation in initial latency and the number of concurrent user requests that can be supported. Our simulation results show that, in proportion to the static buffer allocation scheme, the dynamic buffer allocation scheme reduces the average initial latency by 29% ~ 65%, and, in a system having several disks, increases the average number of concurrent user requests by 48% ~ 68%. Our results show that the dynamic buffer allocation scheme significantly improves the performance and reduce the capacity requirements of VOD systems.