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WEATHER CHARACTERISTICS AT OBSERVATORY CANDIDATE SITES IN WEST TIBET
SASAKI, TOSHIYUKI,NAOE, HIROAKI,UTSUMI, YOSUKE,WANG, HONGSHUAI,YAO, YONGQIANG,YOSHIDA, MICHITOSHI,OHSHIMA, NORIO,MIKAMI, YOSHITAKA,OKADA, NORIO,KOYANO, HISASHI,SEKIGUCHI, KAZUHIRO,ANDO, HIROYASU,LIU, The Korean Astronomical Society 2015 天文學論叢 Vol.30 No.2
The high plateaus in west China may provide suitable sites for astronomical observations with the institute's middle-range telescopes and possibly with larger telescopes. Under China-Japan collaborations for site survey in west China, we have been conducting searches for good sites and monitoring their characteristics over several years. As recent results of our site survey show, sites in west Tibet are revealed with a high possibility of good astronomical observations. Weather characteristics at Gar in Ali, Tibet, show its high clear-sky ratios, especially in winter, comparable to Mauna Kea, Hawaii. But it has some wind problem in winter, where stronger wind speeds, over 20m/sec, occur frequently even though the sky is clear. To find calmer sites, we have conducted numerical simulations for the Ali area using the Japan Meteorological Agency NonHydrostatic Model. We have found another site, named ZoZo Hill, near Gar. We will continue to monitor the Gar site to clarify weather characteristics over the whole year and hopefully start to negotiate for site monitoring at ZoZo Hill this year.
EMISSION LINE VELOCITY FIELD OF THE MAGELLANIC IRREGULAR GALAXY NGC 4449
SASAKI MINORU,OHTANI HIROSHI,SAITO MAMORU,OHTA KOUJI,YOSHIDA MICHITOSHI,SHIMIZU TASUHlRO,KOYANO HISASHI,KOSUGI GEORGE,AOKI KENTARO,SASAKI TOSHIYUKI The Korean Astronomical Society 1996 Journal of The Korean Astronomical Society Vol.29 No.suppl1
The imaging spectroscopic observations of the Magellanic irregular galaxy NGC 4449 were made to show the detailed kinematic structure of the galaxy. Many filamentary structures and Several bubble-like structures are recognized in a 3D data cube of H$\alpha$ emission line. Velocity field shows the kpc-scale mosaic structure and counter- rotation of ionized gas.
Tumor necrosis factor-α converting enzyme is a key mediator of abdominal aortic aneurysm development
Kaneko, Hidehiro,Anzai, Toshihisa,Horiuchi, Keisuke,Kohno, Takashi,Nagai, Toshiyuki,Anzai, Atsushi,Takahashi, Toshiyuki,Sasaki, Aya,Shimoda, Masayuki,Maekawa, Yuichiro,Shimizu, Hideyuki,Yoshikawa, Tsu Elsevier 2011 Atherosclerosis Vol.218 No.2
<P><B>Abstract</B></P><P><B>Objective</B></P><P>Tumor necrosis factor (TNF)-α is known to be elevated in plasma and the aorta in abdominal aortic aneurysm (AAA) patients. We sought to clarify the role of TNF-α converting enzyme (Tace), which cleaves the transmembrane precursor of TNF-α, in AAA development.</P><P><B>Methods</B></P><P>We obtained aortic sample of AAA during surgical operation to assess the histological features and protein expression of human AAA. AAA was induced in mice with temporal systemic deletion of Tace by the inducible Mx-1 Cre transgene (TaceMx1) and in wild-type littermates (CON) by periaortic application of CaCl<SUB>2</SUB> (AAA/TaceMx1, AAA/CON).</P><P><B>Results</B></P><P>Tace expression was increased in human AAA samples as compared with normal aorta. Six weeks postoperatively, aortic diameter in AAA/TaceMx1 was decreased than in AAA/CON in association with attenuated TNF-α expression and extracellular matrix disruption. Increased activities of matrix metalloproteinase (MMP)-9 and MMP-2, numbers of Mac-2-positive macrophages, CD3-positive T lymphocytes and CD31-positive vessels in periaortic tissues, mRNA expression of CD68, monocyte chemotactic protein-1, TNF-α, vascular endothelial growth factor-A, p47 and glutathione peroxidases, and protein expression of phospho-c-Jun N-terminal kinase in AAA were all attenuated by Tace deletion. Protein expression of transforming growth factor (TGF)-β1 was upregulated by Tace deletion in sham-operated mice. TGF-β1 expression was further increased in AAA/TaceMx1.</P><P><B>Conclusions</B></P><P>Tace was overexpressed in the aortic wall in human and experimental AAA. Temporal systemic deletion of Tace prevented AAA development in association with attenuating inflammation, oxidative stress, neoangiogenesis and extracellular matrix disruption, suggesting a crucial role of Tace in AAA development.</P>