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RETRACTED: Marine actinobacterial metabolites: Current status and future perspectives
Manivasagan, P.,Venkatesan, J.,Sivakumar, K.,Kim, S.K. G. Fischer 2013 Microbiological research Vol.168 No.6
This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). This article has been retracted at the request of the Editor. Authors and Editor agreed to retract this article because substantial parts of the text were copied from the following sources without proper attribution: Lam, K.S. (2006), Discovery of novel metabolites from marine actinomycetes. Current Opinion in Microbiology 9(3), pp. 245-251; Subramani, R., Aalbersberg, W. (2012), Marine actinomycetes: An ongoing source of novel bioactive metabolites. Microbiological Research 167(10), pp. 571-580; Dharmaraj, S. (2010), Marine Streptomyces as a novel source of bioactive substances. World Journal of Microbiology and Biotechnology 26(12), pp. 2123-2139. The authors apologize for this oversight and any inconvenience caused.
T Sivakumar,R Rajavel,D Karthikeyan,R Duraisamy,K Srinivasan,S Suresh kumar,Subhas S Karki 경희대학교 융합한의과학연구소 2008 Oriental Pharmacy and Experimental Medicine Vol.8 No.3
The chloroform extract of Croton roxburghii (Family: Euphorbiaceae) was evaluated for its antipyretic effects in Brewer’s yeast induced hyperthermia in rats. The anti-inflammatory effect of the Croton roxburghii was also evaluated by using carrageenan, dextran, histamine, serotonin induced rat paw oedema and cotton pellet induced granuloma (chronic) models in rats. The chloroform extract of Croton roxburghii (CECR) exhibited significant anti-pyretic and antiinflammatory effect at the dose 50, 100 and 200 mg/kg. Maximum inhibition (55.32%) was noted at the dose of 200 mg/kg after 3 h of drug treatment in carrageenan induced paw oedema, whereas the Indomethacin (standard drug) produced 61.33% of inhibition. The extract exhibited significant anti-inflammatory activity in dextran induced paw edema in a dose dependent manner. In the chronic model (cotton pellet induced granuloma) the CECR (200 mg/kg) and Indomethacin (10 mg/kg) showed decreased formation of granuloma tissue by 52.32% and 56.32% respectively. The extract also exhibited a significant antipyretic response in Brewer’s yeast induced pyrexia in rats. Thus, the present study revealed that the CECR exhibited significant antipyretic and anti-inflammatory activity in the tested animal models. The chloroform extract of Croton roxburghii (Family: Euphorbiaceae) was evaluated for its antipyretic effects in Brewer’s yeast induced hyperthermia in rats. The anti-inflammatory effect of the Croton roxburghii was also evaluated by using carrageenan, dextran, histamine, serotonin induced rat paw oedema and cotton pellet induced granuloma (chronic) models in rats. The chloroform extract of Croton roxburghii (CECR) exhibited significant anti-pyretic and antiinflammatory effect at the dose 50, 100 and 200 mg/kg. Maximum inhibition (55.32%) was noted at the dose of 200 mg/kg after 3 h of drug treatment in carrageenan induced paw oedema, whereas the Indomethacin (standard drug) produced 61.33% of inhibition. The extract exhibited significant anti-inflammatory activity in dextran induced paw edema in a dose dependent manner. In the chronic model (cotton pellet induced granuloma) the CECR (200 mg/kg) and Indomethacin (10 mg/kg) showed decreased formation of granuloma tissue by 52.32% and 56.32% respectively. The extract also exhibited a significant antipyretic response in Brewer’s yeast induced pyrexia in rats. Thus, the present study revealed that the CECR exhibited significant antipyretic and anti-inflammatory activity in the tested animal models.
Sivakumar, T,Rajavel, R,Karthikeyan, D,Duraisamy, R,Srinivasan, K,Kumar, S Suresh,Karki, Subhas S Kyung Hee Oriental Medicine Research Center 2008 Oriental pharmacy and experimental medicine Vol.8 No.3
The chloroform extract of Croton roxburghii (Family: Euphorbiaceae) was evaluated for its antipyretic effects in Brewer's yeast induced hyperthermia in rats. The anti-inflammatory effect of the Croton roxburghii was also evaluated by using carrageenan, dextran, histamine, serotonin induced rat paw oedema and cotton pellet induced granuloma (chronic) models in rats. The chloroform extract of Croton roxburghii (CECR) exhibited significant anti-pyretic and anti-inflammatory effect at the dose 50, 100 and 200 mg/kg. Maximum inhibition (55.32%) was notedat the dose of 200 mg/kg after 3 h of drug treatment in carrageenan induced paw oedema, whereas the Indomethacin (standard drug) produced 61.33% of inhibition. The extract exhibited significant anti-inflammatory activity in dextran induced paw edema in a dose dependent manner. In the chronic model (cotton pellet induced granuloma) the CECR (200 mg/kg) and Indomethacin (10 mg/kg) showed decreased formation of granuloma tissue by 52.32% and 56.32% respectively. The extract also exhibited a significant antipyretic response in Brewer's yeast induced pyrexia in rats. Thus, the present study revealed that the CECR exhibited significant antipyretic and anti-inflammatory activity in the tested animal models.
Effect of Surface Condition on the Torsional Fatigue Behaviour of 20MnCr5 Steel
S. Ramesh,S. Natarajan,V. J. Sivakumar 대한금속·재료학회 2021 METALS AND MATERIALS International Vol.27 No.9
Torsional fatigue behaviour of steel is influenced by various significant factors on the surface of steel such as the stress state,the metallurgical conditions and the surface roughness etc. This research presents the results of the studies conducted on thetorsional fatigue life of steel for different surface stresses, conditions and microstructures. Based on the results, inferenceswere derived out of the factors and conditions which are instrumental in increasing the fatigue performance. This researchis done with the purpose of increasing the fatigue performance of power train shafts processed through vacuum carburizingfollowed by second tempering. The fatigue tests were conducted using a bi-directional torsional cyclic loading in a MTSmake torque testing machine. Various researches has been conducted in this paper to find out the impact of surface roughness,second tempering, inter granular oxidation and carbon case depth on the transmission shafts. The existence of surfaceretained austenite has not yielded a notable enhancement in fatigue performance in the power train shaft whereas existenceof martensite with minimum fraction of retained austenite enhanced the fatigue performance significantly from 12,000 to35,000 cycles on ± 3100 N m torque load.
Sivakumar Subramanian,A. S. Sekhar,B. V. S. S. S. Prasad 대한기계학회 2015 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.29 No.6
Leakage characteristics, influenced by centrifugal and thermal radial growth are determined computationally for a generic rotating labyrinthseal used in the gas turbine secondary air system. Three seal locations, namely, R25, R50 and R75 are represented by means ofvarying the rotor radius mimicking different radial positions of the seal from the shaft axis. The combined influence of seal location andits radial (Centrifugal and thermal) growth on the leakage performance is investigated for a wide-ranging speeds from 1000 to 3000 rad/s,temperatures ranging from 200 to 450 oC and pressure ratios varying from 1.1 to 2.5, for a chosen initial clearance of 500 micron. Acomparison of the effect of rotation and temperature gradient among different rotors shows that the radial growth and leakage flow ratessignificantly vary with the increasing radius.
Marine Plastic Pollution in Indo-Pacific: ‘Together’ for Better ‘Future’
S. Sivakumar,Prakash Sharma 한국법제연구원 2021 KLRI journal of law and legislation Vol.11 No.2
According to a 2020 study titled “Changing Sails: Accelerating Regional Actions for Sustainable Oceans in Asia and the Pacific,” the Indo-Pacific region produces nearly half, together with consuming “more than one-third of the total world’s plastic.” It further reveals that owing to the inbuilt constraints in terms of methodology, coupled with inconvenient statistical systems, there remains serious concern for proper data procurement. Further, due to unchecked and uncontrolled human activities, the salubrity of oceans and seas is now “being pushed to a tipping point” and without proper data, the world appears to “swim in the dark.” The picture appears more horrific with COVID-19, particularly with additional reliance placed on the use of plastic. With plenty of challenges there are calls for review of goods production cycles through efficient strategies. In this perspective, we argue, first, no matter where we live, the ocean influences all of us. Therefore, the future we want demand easing of the complex relation between human and oceans, especially in the light of limited Earth’s ability to back rampant human desires. Secondly, the inherently wasteful linear plastic economy has resulted in overconsumption, destructive practices, acidification and subsidies that have caused irreplaceable damage to the state of oceans. As a result, the article maintains that (a) there is a weak legal and institutional framework, and (b) interaction between ocean and human activities, calls for better data demands. Further, the Sustainable Development Goal No. 14 strives towards promoting the health and sustainability of oceans. This holds a great importance, especially for the viable development of the Asia and the Pacific region which inhibits richest pool of the living natural resources in the world. The article suggests that both India and South Korea can take the lead and build up a mechanism of strengthening and promoting scientific know-how, develop research skills and share marine technology.