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RISS 인기검색어
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- 저자 : S. Karaca (검색결과 3 건)
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Analysis of Dam-Reservoir Interaction by Using Homotopy Analysis Method
M. A. Karaca,S. Küçükarslan 대한토목학회 2012 KSCE Journal of Civil Engineering Vol.16 No.1
In this paper, dam-reservoir interaction for a vibrating structure in an unbounded and incompressible and inviscid fluid is analyzed by using homotopy analysis method. In the derivation of the hydrodynamic pressure variable, it is assumed that vibration of dam is in the normal direction of dam-reservoir interface and this interface is vertical. Moreover, bottom of fluid is rigid and horizontal. The results are compared with finite element method and analytical ones. It is seen that the results are efficient and gives better values than the previous published results and this method can be extendable for compressible fluid domains.
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A. Hassani,F. Vafaei,S. Karaca,A. R. KHATAEE 한국공업화학회 2014 Journal of Industrial and Engineering Chemistry Vol.20 No.4
The adsorption ability of Turkish lignite as a cheap and abundant material for removal of methylene blue was investigated. The depending of adsorption capacity on contact time, initial dye concentration, amount of adsorbent, mixing rate, pH and temperature was studied. An artificial neural network was used to model the adsorption process. BET, SEM and FT-IR analysis before and after adsorption were performed. The adsorption kinetic, thermodynamic and isotherm were also investigated. The rate of adsorption was shown the best fit with the pseudo-second order model. The values of thermodynamic parameters indicated that the dye adsorption on the lignite was endothermic.
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Syn, Wing‐,Kin,Choi, Steve S.,Liaskou, Evaggelia,Karaca, Gamze F.,Agboola, Kolade M.,Oo, Ye Htun,Mi, Zhiyong,Pereira, Thiago A.,Zdanowicz, Marzena,Malladi, Padmini,Chen, Yuping,Moylan, Cynthia,J Wiley Subscription Services, Inc., A Wiley Company 2011 Hepatology Vol.53 No.1
<P><B>Abstract</B></P><P>Nonalcoholic steatohepatitis (NASH) is a leading cause of cirrhosis. Recently, we showed that NASH‐related cirrhosis is associated with Hedgehog (Hh) pathway activation. The gene encoding osteopontin (OPN), a profibrogenic extracellular matrix protein and cytokine, is a direct transcriptional target of the Hh pathway. Thus, we hypothesize that Hh signaling induces OPN to promote liver fibrosis in NASH. Hepatic OPN expression and liver fibrosis were analyzed in wild‐type (WT) mice, Patched‐deficient (Ptc<SUP>+/−</SUP>) (overly active Hh signaling) mice, and OPN‐deficient mice before and after feeding methionine and choline–deficient (MCD) diets to induce NASH‐related fibrosis. Hepatic OPN was also quantified in human NASH and nondiseased livers. Hh signaling was manipulated in cultured liver cells to assess direct effects on OPN expression, and hepatic stellate cells (HSCs) were cultured in medium with different OPN activities to determine effects on HSC phenotype. When fed MCD diets, Ptc<SUP>+/−</SUP> mice expressed more OPN and developed worse liver fibrosis (<I>P</I> < 0.05) than WT mice, whereas OPN‐deficient mice exhibited reduced fibrosis (<I>P</I> < 0.05). In NASH patients, OPN was significantly up‐regulated and correlated with Hh pathway activity and fibrosis stage. During NASH, ductular cells strongly expressed OPN. In cultured HSCs, SAG (an Hh agonist) up‐regulated, whereas cyclopamine (an Hh antagonist) repressed OPN expression (<I>P</I> < 0.005). Cholangiocyte‐derived OPN and recombinant OPN promoted fibrogenic responses in HSCs (<I>P</I> < 0.05); neutralizing OPN with RNA aptamers attenuated this (<I>P</I> < 0.05). <I>Conclusion:</I> OPN is Hh‐regulated and directly promotes profibrogenic responses. OPN induction correlates with Hh pathway activity and fibrosis stage. Therefore, OPN inhibition may be beneficial in NASH (H<SMALL>EPATOLOGY</SMALL> 2011)</P>
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