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- 저자 : Ruolin Li (검색결과 3 건)
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PLAGL2 increases adriamycin resistance and EMT in breast cancer cells by activating the Wnt pathway
Li Yuxiao,Liu Ruolin,Han Xingzhao,Xu Wei,Liu Yahui 한국유전학회 2023 Genes & Genomics Vol.45 No.1
Background Adriamycin (ADR) is an effective treatment for breast cancer; nevertheless, it is often linked with acquired resistance in breast cancer cells, reducing ADR’s therapeutic efficacy and increasing the risk of recurrence and poor prognosis. It has been revealed that the zinc-finger transcription factor pleomorphic adenoma gene like-2 (PLAGL2) is required for epithelial to mesenchymal transition (EMT) in cancer cells. Recent data indicates that PLAGL2 is also involved in regulating chemotherapeutic drug resistance, albeit the exact mechanism by which this happens remains unknown. Objective This study examines the effect of PLAGL2 on adriamycin resistance and EMT in breast cancer cells. Methods The small interfering RNA (siRNA) targeting PLAGL2 was transfected to breast cancer cells to alter PLAGL2 expression. Cell counting kit-8 (CCK-8) and colony formation assay detected cell growth and proliferation rate. Moreover, wound-healing and transwell assays were conducted to evaluate migration and invasion. Western blot (WB) checked the apoptosis and EMT-associated proteins. Results PLAGL2 expression is associated with breast cancer cells’ acquired resistance to ADR in this investigation. Additionally, deletion of PLAGL2 was associated with enhanced sensitivity to ADR, reduced proliferation, migration, and invasion capabilities, increased E-cadherin levels, and reduced Wnt6, β-catenin, and DVL1 levels in ADR-resistant breast cancer cells (MCF-7/ADR and MDA-MB-231/ADR cells). PLAGL2 could bind to the promoter region of Wnt6 and promote its expression. Additionally, the results of this research established that Wnt signaling is implicated in breast cancer cells’ resistance to ADR since BML-284, a Wnt signaling activator partly restored the sensitivity of MCF-7/ADR and MDA-MB-231/ADR cells to ADR. Conclusion PLAGL2 promotes adriamycin resistance and cell aggressiveness in breast cancer cells via activating the Wnt signaling pathway.
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Chao Zhang,Guo-Qiang Li,Ruolin Wang 한국강구조학회 2013 International Journal of Steel Structures Vol.13 No.3
This paper provides a new way to calculate the temperature of steel components in localized fires. A newly developed concept named adiabatic surface temperature (AST) on fire-structural interface research has been used in the calculation to represent the fire exposed boundary conditions. Based on AST, a simple heat transfer model with the capability of considering heat conduction among different parts of the steel sections has been proposed. The popular CFD code FDS (version 5.3.0),which can output ASTs, has been adopted to simulate the heating of a steel beam and a steel column in a localized fire. Steel temperatures calculated by the proposed model agree very well with the results from CFD simulation. Studies also obviously show that using the surrounding gas temperatures for thermal calculation of steel members exposed to fire might yield unreasonable and unsafe results.
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Microstructure and Hydrogen Absorption Properties of a BCC Phase Accompanied Laves Alloy
Yunlong Zhang,Tiebang Zhang,Jinshan Li,Ruolin Li,Yun Yu,Yalin Lu 대한금속·재료학회 2019 METALS AND MATERIALS International Vol.25 No.3
A non-stoichiometry Zr0.7Ti0.4V1.5Cr0.4alloy has been synthesized by arc melting following annealing treatment or meltspinningto obtain the bulk and ribbon samples, respectively. XRD investigation reveals the multiphase structure consistingof C15-Laves, V-BCC and a small amount of α-Zr or Zr3V3O. The alloy shows easy activation and fast hydrogenationkinetics. The annealed alloy absorbs 2.51 wt% H at room temperature, higher than the melt-spun ribbons. Refined grains bymelt-spinning accelerates the hydrogenation of bulk alloy. The absorption behavior in presence of 1 mol% air has been testedto evaluate the anti-poisoning ability. Pressure–composition–temperature characteristics and thermodynamics parametersindicate the low equilibrium pressure and high hydrides stability. Hydrides investigation reveals that the Laves phase dominantmultiphase structure contributes to the enhanced hydrogen capacity and multi-stage hydrogen release in DSC curve.
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