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Han Zhang,Qi Zhang,Tingting Gao,Yixi Kong,Zeying Qin,Yueyang Hu,Ruilin Cao,Songli Mei 대한신경정신의학회 2019 PSYCHIATRY INVESTIGATION Vol.16 No.5
Objective: This study aims to examine the parallel multiple mediators of depressive symptoms and sleep quality in the relations between stress and physical health-related quality of life (PHQOL)/mental health-related quality of life (MHQOL) among the women in late pregnancy. Methods: Of 1120 pregnant women participated in the cross-sectional study which consisted of Perceived Stress Scale, Edinburgh Postnatal Depression Scale, Pittsburgh Sleep Quality Index and MOS 12-item Short Form Health Survey. Parallel multiple mediator models were used to analyze the relations between stress, depressive symptoms, sleep quality and PHQOL/MHQOL. Results: The effect of perceived stress on PHQOL was partially through the indirect path of sleep quality (β=-0.061). But in the model for MHQOL, depressive symptoms and sleep quality played parallel mediators, and the indirect path effect of depressive symptoms (β=-0.179) was higher than sleep quality (β=-0.029). Conclusion: The findings contributed to the understanding about the influential mechanism of stress on PHQOL/MHQOL. And it reminded the importance of sleep quality and depressive symptoms for improving QOL in late pregnancy.
Yufei Tian,Wei Yang,Gang Chen,Chuanlong Men,Yifan Gu,Ruilin Zhang,Laiyou Wang,Xin Zhang 한국식품과학회 2022 Food Science and Biotechnology Vol.31 No.2
Currently, gut microbiota living in the gastrointestinaltract, plays an important role in regulatinghost’s sleep and circadian rhythms. As a tool, gut microbiotahas great potential for treating circadian disturbanceand circadian insomnia. However, the relationship betweengut microbiota and circadian rhythms is still unclear, andthe mechanism of action has still been the focus ofmicrobiome research. Therefore, this article summarizesthe current evidences associating gut microbiota with factorsthat impact host circadian rhythms neurology sleepdisorder. Moreover, we discuss the changes to these systemsin sleep disorder and the potential mechanism ofintestinal microbiota in regulating circadian rhythms neurologysleep disorder via microbial metabolites. Meanwhile,based on the role of intestinal flora, it is provided anovel insight into circadian related insomnia and will bebenefit the dietary treatment of circadian disturbance andthe circadian related insomnia.