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RISS 인기검색어
- 검색키워드
- 저자 : Rui Moreira (검색결과 4 건)
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Rui A.S. Moreira,Francisco J.Q. de Melo,Jose Dias Rodrigues 한국소성가공학회 2010 기타자료 Vol.2010 No.6
This work is devoted to the analysis of the static and dynamic properties of composition corks used as damping cores in sandwich structures. A mixed displacement-stress beam finite element is formulated, implemented and used as a valuable numerical tool in an inverse identification methodology, where the core material is characterized from the free vibration response of the sandwich beam. The obtained values for the storage modulus and loss factor are compared to the static Young"s modulus identified from an experimental characterization analysis using compression and tensile tests.
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Rui Moreira,Fernando Bimbela,Noemí Gil-Lalaguna,José Luis Sánchez,António Portugal 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.101 No.-
Using lignocellulosic char instead of the original biomass avoids the need for costly cleaning andconditioning stages of the producer gasification gas. However, lignocellulosic char gasification has beenless extensively studied than gasification of lignocellulosic biomass, and a review of published works onthis topic was missing. In this review the present status of char gasification technologies and their futureprospects are critically discussed, including possible research opportunities. To date, most studies onchar gasification have been performed in thermogravimetric analyzers (TGA) or TGA-like experimentalsetups. The major setback of TGA and TGA-like equipment is that they do not mimic the actual reactionconditions occurring in gasification reactors, which impedes a direct extrapolation of thefindings duringthe scale-up of different gasification technologies. For this reason, in this literature review focus was puton studies undertaken in industrially relevant reactors, both in batch and continuous configurations. Overall, char gasification can be deemed a valid alternative for clean syngas production, contributing toan integral valorization of lignocellulosic residues within different biorefinery schemes. Of these, processintensification by microwave heating offers interesting opportunities for research and scaling-up, thoughefforts must be directed toward developing continuous microwave-assisted gasification processes.
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Saul Matos de Castro,Rui Moreira,Ana Cristina Braga,Afonso Pinhao Ferreira,Maria Cristina Pollmann 대한치과교정학회 2015 대한치과교정학회지 Vol.45 No.4
Objective: To quantify, for each activation, the effect of preactivations of differing distribution and intensity on the neutral position of T-loops (7-mm height), specifically the horizontal force, moment to force (M/F) ratio, and load to deflection ratio. Methods: A total 100 loops measuring 0.017 × 0.025 inches in cross-section were divided into two groups (n = 50 each) according to composition, either stainless steel or beta-titanium. The two groups were further divided into five subgroups, 10 loops each, corresponding to the five preactivations tested: preactivations with occlusal distribution (0°, 20°, and 40°), gingival distribution (20°), and occlusal-gingival distribution (40°). The loops were subjected to a total activation of 6-mm with 0.5-mm iterations. Statistical analysis was performed using comprised ANOVA and Bonferoni multiple comparison tests, with a significance level of 5%. Results: The location and intensity of preactivation influenced the force intensity. For the M/F ratio, the highest value achieved without preactivation was lower than the height of the loop. Without preactivation, the M/F ratio increased with activation, while the opposite effect was observed with preactivation. The increase in the M/F ratio was greater when the preactivation distribution was partially or fully gingival. Conclusions: Depending on the preactivation distribution, displacement of uprights is higher or lower than the activation, which is a factor to consider in clinical practice.
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Daniel B. Rodrigues,Helena R. Moreira,Mariana T. Cerqueira,Alexandra P. Marques,António G. Castro,Rui L. Reis,Rogério P. Pirraco 한국생체재료학회 2022 생체재료학회지 Vol.26 No.4
Background: T cell priming has been shown to be a powerful immunotherapeutic approach for cancer treatment in terms of efficacy and relatively weak side effects. Systems that optimize the stimulation of T cells to improve therapeutic efficacy are therefore in constant demand. A way to achieve this is through artificial antigen presenting cells that are complexes between vehicles and key molecules that target relevant T cell subpopulations, eliciting antigenspecific T cell priming. In such T cell activator systems, the vehicles chosen to deliver and present the key molecules to the targeted cell populations are of extreme importance. In this work, a new platform for the creation of T cell activator systems based on highly tailorable nanoparticles made from the natural polymer gellan gum (GG) was developed and validated. Methods: GG nanoparticles were produced by a water in oil emulsion procedure, and characterized by dynamic light scattering, high resolution scanning electronic microscopy and water uptake. Their biocompatibility with cultured cells was assessed by a metabolic activity assay. Surface functionalization was performed with anti-CD3/CD28 antibodies via EDC/NHS or NeutrAvidin/Biotin linkage. Functionalized particles were tested for their capacity to stimulate CD4+ T cells and trigger T cell cytotoxic responses. Results: Nanoparticles were approximately 150 nm in size, with a stable structure and no detectable cytotoxicity. Water uptake originated a weight gain of up to 3200%. The functional antibodies did efficiently bind to the nanoparticles, as confirmed by SDS-PAGE, which then targeted the desired CD4+ populations, as confirmed by confocal microscopy. The developed system presented a more sustained T cell activation over time when compared to commercial alternatives. Concurrently, the expression of higher levels of key cytotoxic pathway molecules granzyme B/perforin was induced, suggesting a greater cytotoxic potential for future application in adoptive cancer therapy. Conclusions: Our results show that GG nanoparticles were successfully used as a highly tailorable T cell activator system platform capable of T cell expansion and re-education.
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