Influence of Stimulant Medication on Pedestrian Safety for Children with Excessive Daytime Sleepiness

Rouse Jenni B.,Avis Kristin T.,Schwebel David C. 대한수면학회 2021 sleep medicine research Vol.12 No.1

Background and Objective Pedestrian crashes represent a leading cause of pediatric injury. Children have particular risk due to underdeveloped cognitive and executive function skills. Given children with excessive daytime sleepiness (EDS) face deficiencies in executive function and cognitive skill that impact cognitive functions necessary for safe pedestrian engagement, this study examined whether treatment with the stimulant medication modafinil might improve both cognitive functioning and pedestrian safety among children with EDS. Methods Twelve children aged 8–16 years diagnosed with EDS participated in a within-subjects experiment. Children completed two laboratory visits, one while treated with modafinil and one untreated. During each visit, children completed two self-report sleepiness inventories, two cognitive tests [psychomotor vigilance test (PVT) and Conners’ continuous performance task (CPT; version 3.0, Multi-Health Systems, Inc.)], and 20 virtual pedestrian environment street-crossings. Parents completed a sleepiness survey about children. Results Related samples t-tests found consistent patterns of reduced sleepiness, improved cognitive functioning, and safer pedestrian behavior while children were medicated with modafinil compared to unmedicated. Statistically significant differences emerged for parent-reported child sleepiness (p < 0.01); PVT false starts, indicating improved attention, vigilance and alertness (p < 0.10); CPT omissions, signifying failure to respond to stimuli (p < 0.05); and shortest time-to-contact with oncoming virtual traffic (p < 0.05). Chi-square demonstrated children had fewer collisions with oncoming virtual traffic while medicated than unmedicated (p < 0.05). Conclusions Medication with the stimulant modafinil improved multiple aspects of cognitive functioning and pedestrian safety among children with EDS. The greatest benefits emerged on measures of alertness, attention, and response latency. Results suggest modafinil may improve real-world functioning in tasks like crossing streets.

Regulatory T Cells and Infectious Disease

Rouse, Barry T.,Sehrawat, Sharvan The Korean Association of Immunobiologists 2007 Immune Network Vol.7 No.4

Various cell types that express regulatory function may influence the pathogenesis of most and perhaps all infections. Some regulatory cells are present at the time of infection whereas others are induced or activated in response to infection. The actual mechanisms by which different types of infections signal regulatory cell responses remain poorly understood. However a most likely mechanism is the creation of a microenvironment that permits the conversion of conventional T cells into cells with the same antigen specificity that have regulatory function. Some possible means by which this can occur are discussed. The relationship between regulatory cells and infections is complex especially with chronic situations. The outcome can either be of benefit to the host or damage the disease control process or in rare instances appears to be a component of a finely balanced relationship between the host and the infecting agent. Manipulating the regulatory cell responses to achieve a favorable outcome of infection remains an unfulfilled objective of therapeutic immunology.

수리분과위원회

Hunter Rouse,Simon Lnce 한국수자원학회 1995 한국수자원학회 학술대회 Vol.1995 No.1

Regulatory T Cells and Infectious Disease

BARRY T. ROUSE,SHARVAN SEHRAWAT 대한면역학회 2007 Immune Network Vol.7 No.4

How Do Early Childhood Teachers Understand and Support the Needs of Young English Language Learners?

Carolina Cabezas,Elizabeth Rouse 환태평양유아교육연구학회 2014 Asia-Pacific journal of research in early childhoo Vol.8 No.1

In Australia, over one third of all children in Early Childhood programs speak a first language other than English. Despite considerable work into teachers’ beliefs on cultural diversity, attention to aspects of second language acquisition in the Early Years has been limited within the Early Childhood field. This paper reports on a small study investigating how four early childhood educators understand theory of Second Language Acquisition (SLA) and bilingualism, and how they cater for language-minority students in their programs. The findings revealed a complex interplay between the way participants interpret and support the needs of these children, their experience in the field, and professional education. The teachers in the study reveal various perspectives on how SLA and bilingualism manifest during the early years, and how they affect the learning of children with a Language Background other than English (LBOTE). The teachers also seemed to rely on experiential and intuitive approaches in planning and teaching English Language Learners (ELLs). This study brings new perspectives to understanding the nature of teachers’ beliefs and practice regarding English language learners.

Agreement Level of Inflammatory Bowel Disease Symptom Reports between Children and Their Parents

Angharad Vernon-Roberts,Emma Rouse,Nerissa L Bowcock,Daniel A Lemberg,Andrew S Day 대한소아소화기영양학회 2023 Pediatric gastroenterology, hepatology & nutrition Vol.26 No.2

Purpose: Children with inflammatory bowel disease (IBD) frequently undergo clinical assessments, involving triadic communication between clinician, parent, and child. During such encounters parents are traditionally the main communicator of information on their child’s IBD, including subjective symptom reports. The level of agreement between children and their parents for IBD symptoms is poorly understood, and this study aimed to examine this factor. Methods: This was a cross-sectional study among children with IBD, and one parent. A validated paediatric IBD symptom report tool (IBDnow) enabled children and their parent to rate seven pain, well-being, and stool metrics, with dyads completing the tool concurrently. Results were assessed using: Individual agreement: proportion of identical symptom reports by each dyad (ideal score >0.7); Category agreement: percentage of identical reports for IBDnow metrics for the cohort; Inter-rater reliability: Gwet’s AC1 coefficient with higher scores indicating better reliability (maximum=1). Results: Seventy-four parent/child dyads participated; child’s mean age 12.2 years (standard deviation [SD] 2.9, range 6-16), mean time since diagnosis 2.8 years (SD 3), 54% female, 73% had Crohn’s Disease. Mean individual agreement level was 0.6, with 27% of dyads agreeing on ≥6/7 IBDnow metrics. Category agreement was reported by 61% of dyads, 20% of parents overestimated, and 19% underestimated, their child’s symptoms. Inter-rater reliability ranged from fair to good. Conclusion: These results should improve clinician awareness of how IBD symptom reports from parents may introduce bias. Children should be considered the most important source of symptom reports, and tools such as IBDnow utilised to enhance communication.

The Relevance of Polymeric Synthetic Membranes in Topical Formulation Assessment and Drug Diffusion Study

Shiow-Fern Ng,Jennifer J. Rouse,Francis D. Sanderson,Gillian M. Eccleston 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.4

Synthetic membranes are composed of thin sheets of polymeric macromolecules that can control the passage of components through them. Generally, synthetic membranes used in drug diffusion studies have one of two functions: skin simulation or quality control. Synthetic membranes for skin simulation, such as the silicone-based membranes polydimethylsiloxane and Carbosil‚, are generally hydrophobic and rate limiting, imitating the stratum corneum. In contrast, synthetic membranes for quality control, such as cellulose esters and polysulfone, are required to act as a support rather than a barrier. These synthetic membranes also often contain pores; hence, they are called porous membranes. The significance of Franz diffusion studies and synthetic membranes in quality control studies involves an understanding of the fundamentals of synthetic membranes. This article provides a general overview of synthetic membranes, including a brief background of the history and the common applications of synthetic membranes. This review then explores the types of synthetic membranes, the transport mechanisms across them, and their relevance in choosing a synthetic membrane in Franz diffusion cell studies for formulation assessment purposes.

SUNRISE

Feldman Architecture(펠드먼 아키텍처),Adam Rouse(사진) 현대건축사 2020 (월간)Maru Vol.- No.220

SUNRISE

Feldman Architecture(펠드먼 아키텍처),Adam Rouse(사진) 현대건축사 2020 마루 Vol.- No.220

Blockade of cannabinoid 1 receptor improves GLP-1R mediated insulin secretion in mice

Gonzalez-Mariscal, I.,Krzysik-Walker, S.M.,Kim, W.,Rouse, M.,Egan, J.M. North-Holland 2016 Molecular and cellular endocrinology Vol.423 No.-

<P>The cannabinoid 1 receptor (CBI) is an important regulator of energy metabolism. Reports of in vivo and in vitro studies give conflicting results regarding its role in insulin secretion, possibly due to circulatory factors, such as incretins. We hypothesized that this receptor may be a regulator of the entero-insular axis. We found that despite lower food consumption and lower body weight postprandial GLP-1 plasma concentrations were increased in CB1(-/-) mice compared to CB1(+/+) mice administered a standard diet or high fat/sugar diet. Upon exogenous GLP-1 treatment, CB1(-/-) mice had increased glucose stimulated insulin secretion. In mouse insulinoma cells, cannabinoids reduced GLP-1R-mediated intracellular CAMP accumulation and subsequent insulin secretion. Importantly, such effects were also evident in human islets, and were prevented by pharmacologic blockade of CB1. Collectively, these findings suggest a novel mechanism in which endocannabinoids are negative modulators of incretin-mediated insulin secretion. (C) 2015 Elsevier Ireland Ltd. All rights reserved.</P>