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- 저자 : Romina Sepehri (검색결과 1 건)
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Romina Sepehri,Payam Zahedi,Mahboubeh Kabiri,Chakavak Nojavan 한국섬유공학회 2022 Fibers and polymers Vol.23 No.11
Coating polymeric nanofibers with anti-coagulant agents is one of the most important methods to enhance theperformance of these materials against blood interactions. In this work, poly(ethylene terephthalate) (PET)/graphene oxide(GO) nanofibers coated with heparin (Hep) were fabricated and their physicochemical properties alongside hemocompatibilitywere investigated. To study the effect of GO on PET nanofibers, the electrical conductivity of 4.08×10-8 S cm-1 and elasticmodulus of approximately 47 MPa for sample containing 3 wt.% of GO (PET/GO 3) were observed. After NH3 plasma, Hepwas coated on the optimal PET/GO 3 nanofibrous sample and Fourier transform infrared spectroscopy as well as watercontact angle results exhibited the appropriate Hep coating by dedicating characteristic peak of 1187 cm-1 and 25 °,respectively. In addition, the scanning electron microscopic images of PET/GO 3 nanofibers showed Hep coating has nosignificant influence on the size of nanofibrous diameter. Prothrombin time and partial thromboplastin time were increasedup to 106 s and 350 s; additionally, the number of platelets and hemolytic index were decreased in PET/GO 3 nanofibers inpresence of Hep. Eventually, cultivation of mesenchymal stem cells revealed that the sample coated with Hep dedicated thehighest cell proliferation with the most living cells. The overall outcomes conducted us the Hep-coated PET/GO 3nanofibrous sample was a promising candidate for vascular tissue engineering.
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