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RISS 인기검색어
- 검색키워드
- 저자 : Mahboubeh Kabiri (검색결과 3 건)
- 무료
- 기관 내 무료
- 유료
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Herbal Extract Loaded Chitosan/PEO Nanocomposites as Antibacterial Coatings of Orthopaedic Implants
Zahra Kharat,Minoo Sadri,Mahboubeh Kabiri 한국섬유공학회 2021 Fibers and polymers Vol.22 No.4
One of the most substantial complications in orthopedic surgeries is implant associated infection. While theimplant interface can be a permissive surface for bacterial colonization, an appropriate coating on the implant can effectivelyhinder biofilm formation. To this aim, henna and thyme extract loaded into a chitosan (CS)/polyethylene oxide (PEO) basednanofibrous hydrogel. CS/PEO/henna and CS/PEO/thymus extract nanofibers were fabricated via two-nozzle electrospinning. The proper weight ratio of CS/PEO/herbal extract was optimized. The appropriate ratio of CS/PEO and the most suitableextract concentrations was obtained to be 7/3 (v/v) and 1 % (v/v), respectively. Contact angle measurements showed anappropriate degree of hydrophilicity in all groups including herbal loaded electrospun nanosheets. Tensile strengthmeasurements showed that inclusion of henna and thymus made minor changes in tensile strength and strain of herbal loadednanofiber, compared to control CS/PEO fibers. Then antibacterial tests were performed and the fibers either by themselves orwhen used as coating on orthopedic screws exhibited a good inhibition zone against both gram negative and gram positivebacteria. The coatings showed no adverse effect on the red blood cells in leading to hemolysis. Cytocompatibility assayindicated that the prepared nanofibrous hydrogel coating was absolutely biocompatible as tested with fibroblast cells. Theresults of this study indicated that our henna and thyme extracts loaded CS/PEO coatings can be used in various medicalfields such as wound dressing and implantation coating to prevent bacterial adhesion, growth and generally, infection.
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Romina Sepehri,Payam Zahedi,Mahboubeh Kabiri,Chakavak Nojavan 한국섬유공학회 2022 Fibers and polymers Vol.23 No.11
Coating polymeric nanofibers with anti-coagulant agents is one of the most important methods to enhance theperformance of these materials against blood interactions. In this work, poly(ethylene terephthalate) (PET)/graphene oxide(GO) nanofibers coated with heparin (Hep) were fabricated and their physicochemical properties alongside hemocompatibilitywere investigated. To study the effect of GO on PET nanofibers, the electrical conductivity of 4.08×10-8 S cm-1 and elasticmodulus of approximately 47 MPa for sample containing 3 wt.% of GO (PET/GO 3) were observed. After NH3 plasma, Hepwas coated on the optimal PET/GO 3 nanofibrous sample and Fourier transform infrared spectroscopy as well as watercontact angle results exhibited the appropriate Hep coating by dedicating characteristic peak of 1187 cm-1 and 25 °,respectively. In addition, the scanning electron microscopic images of PET/GO 3 nanofibers showed Hep coating has nosignificant influence on the size of nanofibrous diameter. Prothrombin time and partial thromboplastin time were increasedup to 106 s and 350 s; additionally, the number of platelets and hemolytic index were decreased in PET/GO 3 nanofibers inpresence of Hep. Eventually, cultivation of mesenchymal stem cells revealed that the sample coated with Hep dedicated thehighest cell proliferation with the most living cells. The overall outcomes conducted us the Hep-coated PET/GO 3nanofibrous sample was a promising candidate for vascular tissue engineering.
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Fatemeh Salahi Chashmi,Mehrdad Khakbiz,Payam Zahedi,Mahboubeh Kabiri 한국섬유공학회 2022 Fibers and polymers Vol.23 No.8
Using poly(lactic acid) (PLA) as biodegradable and biocompatible material is demanded for vascular scaffoldsespecially a susceptible substitute of permanent metal stents in treatment of coronary heart disease. In this work, PLAnanofibers containing aspirin (Asp) loaded into zeolitic imidazolate framework nanoparticles (ZIF-8@Asp NPs) wereprepared for vascular tissue application. In this line, ZIF-8@Asp NPs were synthesized, and their characterization revealedtheir average NP size and the drug loading efficiency of approximately 180 nm and 76 %. Afterward, ZIF-8@Asp NPs wereloaded into PLA nanofibers and the obtained results showed a uniform morphology with an average nanofibers diameter ofaround 544 nm, Young’s modulus of 1.7 MPa, and the ultimate drug release of 19 % after six days. Besides degradationstudies of the sample, the addition of ZIF-8@Asp NPs to the PLA nanofibers displayed no adverse effect on the shaperecovery properties. Finally, the hemolysis and platelet adhesion confirmed that the surface of the ZIF-8@Asp-loaded PLAnanofibrous samples exhibited appropriate hemocompatibility.
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