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        • KCI등재SCOPUS

          Apoptosis Induction Effects of EGCG in Laryngeal Squamous Cell Carcinoma Cells through Telomerase Repression

          Xi,Wang,Miao-Wang,Hao,Ke,Dong,Fang,Lin,Ji-Hong,Ren,Hui-Zhong,Zhang 대한약학회 2009 Archives of Pharmacal Research Vol.32 No.9

          Epigallocatechin-3-gallate (EGCG), the major component of green tea polyphenol, has potent efficiency to prevent the growth of a variety of cancer cells. As a novel anticancer agent for treatment of cancers, EGCG is promising and the mechanism has not been fully understood. Laryngeal squamous cell carcinoma (LSCC) is one common tumor in head and neck cancers. In the present study, we assess the effects of EGCG on LSCC cell line Hep-2, and their possible involvement in EGCG-induced apoptosis. The result showed that treatment of Hep-2 cells with EGCG decreased the cell viability, inhibited the growth and proliferation, induced apoptosis and increased the activity of caspase-3 in a dose-dependent manner. Furthermore, we found that EGCG-treatment repressed telomerase activity effectively in a concentrationdependent manner. The combined results show that EGCG induced apoptosis in Hep-2 cells via inhibiting the telomerase activity. Epigallocatechin-3-gallate (EGCG), the major component of green tea polyphenol, has potent efficiency to prevent the growth of a variety of cancer cells. As a novel anticancer agent for treatment of cancers, EGCG is promising and the mechanism has not been fully understood. Laryngeal squamous cell carcinoma (LSCC) is one common tumor in head and neck cancers. In the present study, we assess the effects of EGCG on LSCC cell line Hep-2, and their possible involvement in EGCG-induced apoptosis. The result showed that treatment of Hep-2 cells with EGCG decreased the cell viability, inhibited the growth and proliferation, induced apoptosis and increased the activity of caspase-3 in a dose-dependent manner. Furthermore, we found that EGCG-treatment repressed telomerase activity effectively in a concentrationdependent manner. The combined results show that EGCG induced apoptosis in Hep-2 cells via inhibiting the telomerase activity.

        • A PORTABLE INTELLIGENT ELECTROCARDIO INSTRUMENT (PIECI)

          Li,,Ren,Xian,Teng,,Ji,Quan,Tan,,Jia,Yu,Zhao,,Xi,Lin 대한전자공학회 1992 HICEC:Harbin International Conference on Electroni Vol.1 No.1

          This paper relates to the principle of PIECI controlled by single chip microcomputer. It is widely used in person's life for its portable, small and lower price. It is the result of computer technics combined with experience in clinic. The structure diagrams and some mathematics modes are given in this paper. Also, the software system function, pseudo difference reconizing and processing technics is dis-cussed in the article.

        • Analysis on Pulse Shaping in Faster-than-Nyquist System

          Yajie,Ren,Jiancun,Fan,Xinmin,Luo,Xi,Chen 대한전자공학회 2017 대한전자공학회 학술대회 Vol.2017 No.1

          In faster-than-Nyquist (FTN) signaling, information symbols are transmitted at a rate higher than that suggested by the Nyquist criterion, which causes unavoidable inter-symbol interference (ISI). As one of the most important part in FTN systems, the selection of shaping pulses draws a lot of attention. Pulse shaping filters are necessary in wireless communication systems to generate band-limited signals and reduce ISI in transmission, and help to decrease the detection complexity as well. For sinc pulses, it has been established that with a small increase in the signaling rate beyond the Nyquist rate, there is no reduction in the minimum Euclidean distance for binary signaling. In this paper, we compare the waveforms of different shaping pulses, and present the ISI with different symbol accelerating factor. Furthermore, we do simulations with different shaping pulses and give the selection of pulses in FTN systems.

        • A 4th-Order Wideband Sigma Delta Modulator Using Linear System Theory Technique

          Ming-yuan,Ren,Yong-sheng,Zhang,Wei-kun,Wu,Zhen-xi,Bao,Zi-wei,Zhao,Chao,Li,Hong-guo,Zhang 보안공학연구지원센터 2016 International Journal of Signal Processing, Image Vol.9 No.1

          A 4th-Order Wideband Sigma Delta modulator structure is proposed in this paper, which uses linear system theory technique. There are many implementation techniques to improve the performance of Sigma Delta ADCs, such as noise coupling, differential sampling and dynamic elements matching. An extra loop delay is needed to be added in the system. This paper explains how to make the modulator stable with the addition of feed-forward and feed-back branches which are used to compensate the extra loop delay. Next, we restore the signal and noise transfer functions. A 4th-Order Wideband delta-sigma modulator have been designed and simulated to verify the method.

        • KCI등재

          FLOURY ENDOSPERM12 Encoding Alanine Aminotransferase 1 Regulates Carbon and Nitrogen Metabolism in Rice

          Mingsheng,Zhong,Xi,Liu,Feng,Liu,Yulong,Ren,Yunlong,Wang,Jianping,Zhu,Xuan,Teng,Erchao,Duan,Fan,Wang,Huan,Zhang,Mingming,Wu,Yuanyuan,Hao,Xiaopin,Zhu,Ruonan,Jing,Xiuping,Guo,Ling,Jiang,Yihua,Wang,Jianmi 한국식물학회 2019 Journal of Plant Biology Vol.62 No.1

          Starch is a major storage substance in cerealgrains, and starch biosynthesis is a complex process. In orderto elucidate regulation of the starch biosynthesis pathway, wescreened a series of rice (Oryza sativa L.) endospermmutants. In this study, we identified a floury white-coreendosperm mutant named floury endosperm12 (flo12). Theflo12 mutant exhibited loosely packed starch granules and alower thousand kernel weight compared to wild type. Semithinsections revealed that compound starch grains (SG) inflo12 interior endosperm cells were developed abnormally. Furthermore, amylose content was decreased, while totalprotein content was significantly increased in flo12 grains. Map-based cloning showed that FLO12 encodes rice alanineaminotransferase 1 (OsAlaAT1). OsAlaAT1 is highly expressedin developing endosperm. Subcellular localization showedthat OsAlaAT1 is localized in the cytosol. Moreover, theexpression of most starch synthesis-related genes wasdecreased, while most of the storage protein coding geneshad elevated expression levels in the flo12 mutant. Inaddition, overexpression of the OsAlaAT1 gene increasedgrain weight. In brief, we demonstrated that OsAlaAT1regulates carbon and nitrogen metabolism, which provides anew insight for the improvement of rice quality and yield.

        • SCIESCOPUSKCI등재

          The Effect of Lysine to Protein Ratio on Growth Performance and Efficiency of Nitrogen Utilization in Pigs

          Li,,Defa,Xi,,Pengbin,Wang,,Junxun,Wang,,Jitan,Ren,,Jiping,Kang,,Yufan,Thacker,,P. Asian Australasian Association of Animal Productio 2001 Animal Bioscience Vol.14 No.9

          One feeding trial and two metabolic trials were conducted to investigate the effects of lysine to protein ratio in practical swine diets on growth performance and efficiency of nitrogen retention and utilization in different growing phases. In Trial one (the feeding trial), 90 mixed sex pigs weighing $9.1{\pm}1.4kg$ (Duroc ${\times}$ Landrance ${\times}$ Beijing Black) were used to study the effects of concentrations of 5.2, 5.3, 5.8, 6.4 and 7.2 g lysine/100 g CP in diets containing 1.2% lysine on growth performance and serum urea nitrogen. The results showed that feed conversion efficiency and economic efficiency were best for pigs fed the diet containing the lysine concentration of 5.8 g /100 g crude protein. Serum urea nitrogen concentration decreased linearly (p=0.0009) and serum free lysine content increased linearly (p=0.0017) as the lysine to protein ratio in diets increased from 5.2 to 7.2 g/100 g. In Trials two and three (the metabolic trials), five growing barrows (Duroc ${\times}$ Landrance ${\times}$ Beijing black), with initial body weights of approximately $26{\pm}2.4kg$ and $56.3{\pm}3.5kg$, respectively, were allotted to five dietary treatments according to a $5{\times}5$ Latin square design. Trial two contained 5.2, 5.7, 6.1, 6.7 and 6.8 g lysine/100 g CP treatments. Trial three contained 4.6, 5.0, 5.6, 6.1 and 6.6 g lysine/100 g CP treatments. The results showed that nitrogen retention in growing pigs decreased linearly (p=0.0011 in Trial two; p=0.0099 in Trial three) as the lysine to protein ratio in diets increased. The ratio of lysine to protein in diets resulting in maximum nitrogen retention was 5.2 g/100 g and 5.0 g/100 g in Trial two and Trial three, respectively. In Trial two, apparent biological value and gross nitrogen efficiency increased linearly (p=0.0135 and p=0.0192, respectively) as the lysine to protein ratio increased from 5.2 to 6.8 g lysine/100 g CP. In summary, we concluded that the optimal Lysine to Protein Ratios for 8-20 kg and 20-80 kg pigs were 5.8 g/100 g and 5.0 to 5.2 g/100 g, respectively.

        • SCIESCOPUSKCI등재

          Plasma D-dimer Can Effectively Predict the Prospective Occurrence of Ascites in Advanced Schistosomiasis Japonica Patients

          Wu,,Xiaoying,Ren,,Jianwei,Gao,,Zulu,Xu,,Yun,Xie,,Huiqun,Li,,Tingfang,Cheng,,Yanhua,Hu,,Fei,Liu,,Hongyun,Gong,,Zhihong,Liang,,Jinyi,Shen,,Jia,Liu,,Zhen,Wu,,Feng,Sun,,Xi,Niu,,Zhongzheng,Ning,,An The Korean Society for Parasitology 2017 The Korean Journal of Parasitology Vol.55 No.2

          China still has more than 30,000 patients of advanced schistosomiasis while new cases being reported consistently. D-dimer is a fibrin degradation product. As ascites being the dominating symptom in advanced schistosomiasis, the present study aimed to explore a prediction model of ascites with D-dimer and other clinical easy-achievable indicators. A case-control study nested in a prospective cohort was conducted in schistosomiasis-endemic area of southern China. A total of 291 patients of advanced schistosomiasis were first investigated in 2013 and further followed in 2014. Information on clinical history, physical examination, and abdominal ultrasonography, including the symptom of ascites was repeatedly collected. Result showed 44 patients having ascites. Most of the patients' ascites were confined in the kidney area with median area of $20mm^2$. The level of plasma D-dimer and pertinent liver function indicators were measured at the initial investigation in 2013. Compared with those without ascites, cases with ascites had significantly higher levels of D-dimer ($0.71{\pm}2.44{\mu}g/L$ vs $0.48{\pm}2.12{\mu}g/L$, P=0.005), as well ALB (44.5 vs 46.2, g/L) and Type IV collagen (50.04 vs $44.50{\mu}g/L$). Receiver operating characteristic curve analyses indicated a moderate predictive value of D-dimer by its own area under curve (AUC) of 0.64 (95% CI: 0.54-0.73) and the cutoff value as $0.81{\mu}g/L$. Dichotomized by the cutoff level, D-dimer along with other categorical variables generated a prediction model with AUC of 0.76 (95% CI: 0.68-0.89). Risks of patients with specific characteristics in the prediction model were summarized. Our study suggests that the plasma D-dimer level is a reliable predictor for incident ascites in advanced schistosomiasis japonica patients.

        • KCI등재SCOPUS

          Prediction of Wind Power by Chaos and BP Artificial Neural Networks Approach Based on Genetic Algorithm

          Dai-Zheng,Huang,Ren-Xi,Gong,Shu,Gong 대한전기학회 2015 Journal of Electrical Engineering & Technology Vol.10 No.1

          It is very important to make accurate forecast of wind power because of its indispensable requirement for power system stable operation. The research is to predict wind power by chaos and BP artificial neural networks (CBPANNs) method based on genetic algorithm, and to evaluate feasibility of the method of predicting wind power. A description of the method is performed. Firstly, a calculation of the largest Lyapunov exponent of the time series of wind power and a judgment of whether wind power has chaotic behavior are made. Secondly, phase space of the time series is reconstructed. Finally, the prediction model is constructed based on the best embedding dimension and best delay time to approximate the uncertain function by which the wind power is forecasted. And then an optimization of the weights and thresholds of the model is conducted by genetic algorithm (GA). And a simulation of the method and an evaluation of its effectiveness are performed. The results show that the proposed method has more accuracy than that of BP artificial neural networks (BP-ANNs).

        • KCI등재SCOPUS

          Effect of Circuit Parameters on Stability of Voltage-fed Buck-Boost Converter in Discontinuous Conduction Mode

          Zhao-He,Feng,Ren-Xi,Gong,Qing-Yu,Wang 대한전기학회 2014 Journal of Electrical Engineering & Technology Vol.9 No.4

          The state transition matrix are obtained by solving state equations in terms of Laplace inverse transformation and Cayley-Hamilton theorem, and an establishment of a precise discreteiterative mapping of the voltage-fed buck-boost converter operating in discontinuous conduction mode is made. On the basis of the mapping, the converter bifurcation diagrams and Lyapunov exponent diagrams with the input voltage, the resistance, the inductance and the capacitance as the bifurcation parameters are obtained, and the effect of the parameters on the system stability is deeply studied. The results obtained show that they have a great influence on the stability of the system, and the general trend is that the increase of either the voltage-fed coefficient, input voltage or the load resistance, or the decrease of the filtering inductance, capacitance will make the system stability become poorer, and that all the parameters have a critical value, and when they are greater or less than the values, the system will go through stable 1T orbits, stable 2T orbits, 4T orbits, 8T orbits and eventually approaches chaos.

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