Dehydration Reduces Crack Development in IQF “Baby Carrots”

Rajasekaran R. Lada,Philip Joy,Cameron Fullerton,Brian Williums,Angus Ells 한국원예학회 2006 한국원예학회 기타간행물 Vol.- No.-

Antibacterial, Antifungal and Anticonvulsant Evaluation of Novel Newly Synthesized 1-[2-(1H-Tetrazol-5-yl)ethyl]-1H-benzo[d][1,2,3]triazoles

Rajasekaran, Aiyalu,Murugesan, Sankaranarayanan,AnandaRajagopal, Kalasalingam The Pharmaceutical Society of Korea 2006 Archives of Pharmacal Research Vol.29 No.7

Several novel 1-[2-(1H-tetrazol-5-yl) ethyl]-1H-benzo[d][1,2,3]triazoles (3a-h) have been synthesized by the condensation of 1-[2-(1H-tetrazol-5-yl)-ethyl]-1H-benzotriazole (2) and appropriate acid chlorides. 1-[2-(1H-tetrazol-5-yl)-ethyl]-1H-benzotriazole (2) was synthesized by reacting 3-(1H-benzo[d][1,2,3]triazol-1-yl)propanenitrile with sodium azide and ammonium chloride in the presence of dimethylformamide. The synthesized compounds were characterized by IR and PMR analysis. The titled compounds were evaluated for their in vitro antibacterial and antifungal activity by the cup plate method and anticonvulsant activity evaluated by the maximal electroshock induced convulsion method in mice. All synthesized compounds exhibited moderate antibacterial activity against Bacillus subtilis and moderate antifungal activity against Candida albicans. Compounds 5-(2-(1 H-benzo[d][1,2,3]triazo-1-yl)ethyl)-1H-tetrazol-1-yl)(4-aminophenyl)methanone 3d and 5-(2-(1 H-benzo[d][1,2,3]triazo-1-yl)ethyl)-1H-tetrazol-1-yl)(2-aminophenyl)methanone 3e elicited excellent anticonvulsant activity.

Optimal lay-up of hybrid composite beams, plates and shells using cellular genetic algorithm

Rajasekaran, S.,Nalinaa, K.,Greeshma, S.,Poornima, N.S.,Kumar, V. Vinoop Techno-Press 2003 Structural Engineering and Mechanics, An Int'l Jou Vol.16 No.5

Laminated composite structures find wide range of applications in many branches of technology. They are much suited for weight sensitive structures (like aircraft) where thinner and lighter members made of advanced fiber reinforced composite materials are used. The orientations of fiber direction in layers and number of layers and the thickness of the layers as well as material of composites play a major role in determining the strength and stiffness. Thus the basic design problem is to determine the optimum stacking sequence in terms of laminate thickness, material and fiber orientation. In this paper, a new optimization technique called Cellular Automata (CA) has been combined with Genetic Algorithm (GA) to develop a different search and optimization algorithm, known as Cellular Genetic Algorithm (CGA), which considers the laminate thickness, angle of fiber orientation and the fiber material as discrete variables. This CGA has been successfully applied to obtain the optimal fiber orientation, thickness and material lay-up for multi-layered composite hybrid beams plates and shells subjected to static buckling and dynamic constraints.

Mechanical properties of thin-walled composite beams of generic open and closed sections

Rajasekaran, S. Techno-Press 2005 Structural Engineering and Mechanics, An Int'l Jou Vol.21 No.5

A general analytical model for thin-walled composite beams with an arbitrary open/(or/and) closed cross section and arbitrary laminate stacking sequence i.e., symmetric, anti-symmetric as well as un-symmetric with respect to the mid plane of the laminate, is developed in the first paper. All the mechanical properties, mechanical centre of gravity and mechanical shear centre of the cross section are defined in the function of the geometry and the material properties of the section. A program "fungen" and "clprop" are developed in Fortran to compute all the mechanical properties and tested for various isotropic sections first and compared with the available results. The locations of mechanical centre of gravity and mechanical shear centre are given with respect to the fibre angle variation in composite beams. Variations of bending and torsional stiffness are shown to vary with respect to the fibre angle orientations.

Prediction of concrete strength using serial functional network model

Rajasekaran, S.,Lee, Seung-Chang Techno-Press 2003 Structural Engineering and Mechanics, An Int'l Jou Vol.16 No.1

The aim of this paper is to develop the ISCOSTFUN (Intelligent System for Prediction of Concrete Strength by Functional Networks) in order to provide in-place strength information of the concrete to facilitate concrete from removal and scheduling for construction. For this purpose, the system is developed using Functional Network (FN) by learning functions instead of weights as in Artificial Neural Networks (ANN). In serial functional network, the functions are trained from enough input-output data and the input for one functional network is the output of the other functional network. Using ISCOSTFUN it is possible to predict early strength as well as 7-day and 28-day strength of concrete. Altogether seven functional networks are used for prediction of strength development. This study shows that ISCOSTFUN using functional network is very efficient for predicting the compressive strength development of concrete and it takes less computer time as compared to well known Back Propagation Neural Network (BPN).

The design of a cell-selective fowlicidin-1-derived peptide with both antimicrobial and anti-inflammatory activities

Rajasekaran, Ganesan,Kumar, S. Dinesh,Yang, Sungtae,Shin, Song Yub Elsevier 2019 European journal of medicinal chemistry Vol.182 No.-

<P><B>Abstract</B></P> <P>Fowlicidin-1 (Fowl-1), a cathelicidin expressed in chicken intestine, is known to have both antimicrobial and anti-inflammatory properties. However, its pharmaceutical development has been ultimately compromised by its high host cytotoxicity. In this study, a series of N- and C-terminal-truncated 19-meric Fowl-1 peptides were synthesized. Among these truncated peptides, Fowl-1 (8–26) exhibited broad-spectrum antimicrobial activity without human erythrocyte cytotoxicity while reducing anti-inflammatory activity. Further, Fowl-1 (8–26)-WRK was designed via Thr<SUP>5</SUP>→Trp, Ile<SUP>7</SUP>→Arg, and Asn<SUP>11</SUP>→Lys substitutions in Fowl-1 (8–26) to exhibit more amphipathicity. The results revealed that it exhibited both antimicrobial and anti-inflammatory properties. This study also demonstrated that the inhibitory activity of Fowl-1 (8–26)-WRK against LPS-induced inflammation was mainly due to the binding of LPS to the peptide. Interestingly, compared with human cathelicidin LL-37 and melittin, Fowl-1 (8–26)-WRK showed more potent activity against drug-resistant bacteria. It was also resistant to physiological salts and human serum and acted synergistically in combination with conventional antibiotics, such as chloramphenicol, ciprofloxacin, and oxacillin, suggesting that combined with conventional antibiotics, it is a promising adjuvant. Furthermore, membrane depolarization, SYTOX Green uptake, and flow cytometry revealed that it kills bacteria by damaging their membrane integrity. Therefore, this study suggests that Fowl-1 (8–26)-WRK has considerable potential for future development as an antimicrobial and anti-inflammatory agent for treating antibiotic-resistant infections.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Fowl-1 (8–26)-WRK exerts dual antimicrobial and anti-inflammatory activities. </LI> <LI> Compared to LL-37, Fowl-1 (8–26)-WRK showed more potent activity against drug-resistant bacteria. </LI> <LI> Fowl-1 (8–26)-WRK acted synergistically when combined with conventional antibiotics. </LI> <LI> Fowl-1 (8–26)-WRK has considerable potential for future development as an antimicrobial and anti-inflammatory agent. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

New methodology for light weight solutions to improve BIW structural performance using bulk head optimization

Rajasekaran Mohan,, Hariram Venkatesan,Subramanian Mahadevan 대한기계학회 2016 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.30 No.8

Body-in-white (BIW) is the Car body with welded sheet metal parts painted in white. Automobile companies were trying to optimize mass and improve performance with optimal mass addition. In many automotive industries many BIW designs due to aggressive mass optimization, there is a need to have smart solutions to improve BIW structure performance with very little mass increase. In this paper, a new technique of identifying the optimized internal reinforcements in the BIW at conceptual BIW design phase using Deign of experiments and Multi-objective optimization has been investigated. The paper focus on the Bending and torsion stiffness load cases to evaluate the BIW performance. Bulk head designs were designed at the major joints like A-pillar, B-pillar, C-pillar and rocker and their optimal locations to improve stiffness with minimum mass increase were identified using Design of experiments and multi objective techniques. The research shows that the optimized Bulk head design locations using the DOE technique has improved the overall BIW stiffness performance by 3.9% with 1.2% of mass addition in the BIW.

Proteomic Signature of Nucleus Pulposus in Fetal Intervertebral Disc

Rajasekaran Shanmuganathan,Soundararajan Dilip Chand Raja,Tangavel Chitraa,K.S. Sri Vijay Anand,Nayagam Sharon Miracle,Matchado Monica Steffi,Muthurajan Raveendran,Shetty Ajoy Prasad,Kanna Rishi Muges 대한척추외과학회 2020 Asian Spine Journal Vol.14 No.4

Study Design: Profiling proteins expressed in the nucleus pulposus of fetal intervertebral disc (IVD).Purpose: To evaluate the molecular complexity of fetal IVDs not exposed to mechanical, traumatic, inflammatory, or infective insults to generate improved knowledge on disc homeostasis.Overview of Literature: Low back pain is the most common musculoskeletal disorder, causing a significant reduction in the quality of life, and degenerative disc disorders mainly contribute to the increasing socioeconomic burden. Despite extensive research, the causative pathomechanisms behind degenerative disc disorders are poorly understood. Precise molecular studies on the intricate biological processes involved in maintaining normal disc homeostasis are needed.Methods: IVDs of nine fetal specimens obtained from medical abortions were used to dissect out the annulus fibrosus and nucleus pulposus under sterile operating conditions. Dissected tissues were transferred to sterile Cryovials and snap frozen in liquid nitrogen before transporting to the research laboratory for protein extraction and further liquid chromatography tandem mass spectrometry (LC-MS/ MS) analysis. Collected data were further analyzed using Gene Functional Classification Tool in DAVID and STRING databases.Results: A total of 1,316 proteins were identified through LC-MS/MS analysis of nine fetal IVD tissues. Approximately 247 proteins present in at least four fetal discs were subjected to further bioinformatic analysis. The following 10 clusters of proteins were identified: collagens, ribosomal proteins, small leucine-rich proteins, matrilin and thrombospondin, annexins, protein disulfide isomerase family proteins and peroxiredoxins, tubulins, histones, hemoglobin, and prolyl 4-hydroxylase family proteins.Conclusions: This study provides fundamental information on the proteome networks involved in the growth and development of healthy fetal discs in humans. Systematic cataloging of proteins involved in various structural and regulatory processes has been performed. Proteins expressed most abundantly (collagen type XIV alpha 1 chain, biglycan, matrilin 1, and thrombospondin 1) in their respective clusters also elucidate the possibility of utilizing these proteins for potential regenerative therapies.

Motion-Preserving Navigated Primary Internal Fixation of Unstable C1 Fractures

Rajasekaran Shanmuganathan,Soundararajan Dilip Chand Raja,Shetty Ajoy Prasad,Kanna Rishi Mugesh 대한척추외과학회 2020 Asian Spine Journal Vol.14 No.4

Study Design: Prospective observational study.Purpose: To assess the safety, efficacy, and benefits of computed tomography (CT)-guided C1 fracture fixation.Overview of Literature: The surgical management of unstable C1 injuries by occipitocervical and atlantoaxial (AA) fusion compromises motion and function. Monosegmental C1 osteosynthesis negates these drawbacks and provides excellent functional outcomes.Methods: The patients were positioned in a prone position, and cranial traction was applied using Mayfield tongs to restore the C0–C2 height and obtain a reduction in the displaced fracture fragments. An intraoperative, CT-based navigation system was used to enable the optimal placement of C1 screws. A transverse rod was then placed connecting the two screws, and controlled compression was applied across the fixation. The patients were prospectively evaluated in terms of their clinical, functional, and radiological outcomes, with a minimal follow-up of 2 years.Results: A total of 10 screws were placed in five patients, with a mean follow-up of 40.8 months. The mean duration of surgery was 77±13.96 minutes, and the average blood loss was 84.4±8.04 mL. The mean combined lateral mass dislocation at presentation was 14.6±1.34 mm and following surgery, it was 5.2±1.64 mm, with a correction of 9.4±2.3 mm (<i>p</i> <0.001). The follow-up CT showed excellent placement of screws and sound healing. There were no complications and instances of AA instability. The clinical range of movement at 2 years in degrees was as follows: rotation to the right (73.6°±9.09°), rotation to the left (71.6°±5.59°), flexion (35.4°±4.5°), extension (43.8°±8.19°), and lateral bending on the right (28.4°±10.45°) and left (24.8°±11.77°). Significant improvement was observed in the functional Neck Disability Index from 78±4.4 to 1.6±1.6. All patients returned to their occupation within 3 months.Conclusions: Successful C1 reduction and fixation allows a motion-preserving option in unstable atlas fractures. CT navigation permits accurate and adequate monosegmental fixation with excellent clinical and radiological outcomes, and all patients in this study returned to their preoperative functional status.

Free vibration of tapered arches made of axially functionally graded materials

Rajasekaran, S. Techno-Press 2013 Structural Engineering and Mechanics, An Int'l Jou Vol.45 No.4

The free vibration of axially functionally graded tapered arches including shear deformation and rotatory inertia are studied through solving the governing differential equation of motion. Numerical results are presented for circular, parabolic, catenary, elliptic and sinusoidal arches with hinged-hinged, hinged-clamped and clamped-clamped end restraints. In this study Differential Quadrature element of lowest order (DQEL) or Lagrangian Interpolation technique is applied to solve the problems. Three general taper types for rectangular section are considered. The lowest four natural frequencies are calculated and compared with the published results.