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Qurat-ul-ain Sahi,김용수 한국원자력학회 2018 Nuclear Engineering and Technology Vol.50 No.6
In this article, we conducted molecular dynamics simulations to investigate the effect of applied strainand temperature on irradiation-induced damage in alpha-zirconium. Cascade simulations were performedwith primary knock-on atom energies ranging between 1 and 20 KeV, hydrostatic and uniaxialstrain values ranging from 2% (compression) to 2% (tensile), and temperatures ranging from 100 to1000 K. Results demonstrated that the number of defects increased when the displacement cascadeproceeded under tensile uniaxial hydrostatic strain. In contrast, compressive strain states tended todecrease the defect production rate as compared with the reference no-strain condition. The proportionsof vacancy and interstitial clustering increased by approximately 45% and 55% and 25% and 32% for 2%hydrostatic and uniaxial strain systems, respectively, as compared with the unstrained system, whereasboth strain fields resulted in a 15e30% decrease in vacancy and interstitial clustering under compressiveconditions. Tensile strains, specifically hydrostatic strain, tended to produce larger sized vacancy andinterstitial clusters, whereas compressive strain systems did not significantly affect the size of defectclusters as compared with the reference no-strain condition. The influence of the strain system on radiationdamage became more significant at lower temperatures because of less annealing than in highertemperature systems.
Thickness effect on magnetocrystalline anisotropy of MnPt(0 0 1) film
Qurat-ul-ain,Cuong, Do Duc,Odkhuu, Dorj,Rhim, S.H.,Hong, S.C. Elsevier 2018 Journal of magnetism and magnetic materials Vol.467 No.-
<P><B>Abstract</B></P> <P>We investigated the magnetocrystalline anisotropy (MCA) of MnPt(0 0 1) film and MnPt/MgO(0 0 1) using <I>ab initio</I> electronic structure calculations. We found that the magnetic ground state of the MnPt film strongly depends on thickness (n). In bulk and in film with n ≥ 7 monolayers; AFM-II is the magnetic ground state. However, as the film thickness reduces, the magnetic ground state shifts from AFM-II to AFM-III. We employ layer-by-layer Heisenberg model to explain thickness dependent ground state transition. AFM-III state in the Mn-terminated film shows large perpendicular MCA(PMCA), which further enhances on a MgO(0 0 1) substrate. We conclude that the interface plays a key role for the enhancement of PMCA on the substrate.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Thickness- and surface-termination- dependent MCA of MnPt(0 0 1) film is investigated. </LI> <LI> The Mn-terminated MnPt(0 0 1) film has different magnetic ground state from in bulk when thickness is <7 ML. </LI> <LI> The magnetic structures of the film are studied phenomenologically using rather simplified Heisenberg model. </LI> <LI> The Mn-terminated MnPt(0 0 1) film in AFM-III state shows PMCA when thickness is <9 ML. </LI> <LI> From calculations on MnPt/MgO(0 0 1) it is found that the Mn-O interface enhance PMCA significantly. </LI> </UL> </P>
Comparative proteomics and global genome-wide expression data implicate role of ARMC8 in lung cancer
Amin, Asif,Bukhari, Shoiab,Mokhdomi, Taseem A,Anjum, Naveed,Wafai, Asrar H,Wani, Zubair,Manzoor, Saima,Koul, Aabid M,Amin, Basit,Qurat-ul-Ain, Qurat-ul-Ain,Qazi, Hilal,Tyub, Sumira,Lone, Ghulam Nabi,Q Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.9
Background: Cancer loci comprise heterogeneous cell populations with diverse cellular secretions. Therefore, disseminating cancer-specific or cancer-associated protein antigens from tissue lysates could only be marginally correct, if otherwise not validated against precise standards. Materials and Methods: In this study, 2DE proteomic profiles were examined from lysates of 13 lung-adenocarcinoma tissue samples and matched against the A549 cell line proteome. A549 matched-cancer-specific hits were analyzed and characterized by MALDI-TOF/MS. Results: Comparative analysis identified a total of 13 protein spots with differential expression. These proteins were found to be involved in critical cellular functions regulating pyrimidine metabolism, pentose phosphate pathway and integrin signaling. Gene ontology based analysis classified majority of protein hits responsible for metabolic processes. Among these, only a single non-predictive protein spot was found to be a cancer cell specific hit, identified as Armadillo repeat-containing protein 8 (ARMC8). Pathway reconstruction studies showed that ARMC8 lies at the centre of cancer metabolic pathways. Conclusions: The findings in this report are suggestive of a regulatory role of ARMC8 in control of proliferation and differentiation in lung adenocarcinomas.