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Ganggang Mu,Qianshan Ding,Hongyan Li,Li Zhang,Lingli Zhang,Ke He,Lu Wu,Yunchao Deng,Dongmei Yang,Lianlian Wu,Ming Xu,Jie Zhou,Honggang Yu 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-
The mechanism by which gastrin promotes pancreatic cancer cell metastasis is unclear. The process of directing polarized cancer cells toward the extracellular matrix is principally required for invasion and distant metastasis; however, whether gastrin can induce this process and its underlying mechanism remain to be elucidated. In this study, we found that gastrin-induced phosphorylation of paxillin at tyrosine 31/118 and RhoA activation as well as promoted the metastasis of PANC-1 cancer cells. Depletion of Gα12 and Gα13 inhibited the phosphorylation of paxillin and downstream activation of GTP-RhoA, blocked the formation and aggregation of focal adhesions and facilitated polarization of actin filaments induced by gastrin. Suppression of RhoA and ROCK also exhibited identical results. Selective inhibition of the CCKBR–Gα12/13–RhoA–ROCK signaling pathway blocked the reoriented localization of the Golgi apparatus at the leading edge of migrated cancer cells. YM022 and Y-27632 significantly suppressed hepatic metastasis of orthotic pancreatic tumors induced by gastrin in vivo. Collectively, we demonstrate that gastrin promotes Golgi reorientation and directional polarization of pancreatic cancer cells by activation of paxillin via the CCKBR–Gα12/13–RhoA–ROCK signal pathway.
Xingyou Huang,Xiaowu Yang,Fuhai Geng,Hua Zhang,Qianshan He,Lingbing Bu 한국광학회 2010 Current Optics and Photonics Vol.14 No.3
A micro-pulse LIDAR system (MPL) was employed to measure the aerosol over Pudong, Shanghai from July 2008 to January 2009. Based on Fernald method, aerosol optical variables such as extinction coefficient were retrieved and analyzed. Results show that aerosol exists mainly in low layers; aerosol loading reaches its maximum in the afternoon, and then decreases with time until its minimum at night. Most of the aerosol concentrates in the layer below 3 km, and optical extinction coefficient in the layer below 2 km contributes 84.25% of that below 6 km. Two extinction coefficient peaks appear in the near surface layer up to 500 m and in the level around 1000 m. Aerosol extinction coefficient shows a seasonal downward trend from summer to winter.