Bilateral Acute Anterior Uveitis and Optic Disc Edema Following a Snake Bite

Praveen K Kumar,Shashi Ahuja,Praveen S Kumar 대한안과학회 2014 Korean Journal of Ophthalmology Vol.28 No.2

The authors wish to report a case of bilateral acute anterior uveitis and optic disc edema following ahemotoxic snake bite, in order to highlight the concomitant occurrence of these conditions and the potentialadverse effects of anti-snake venom (ASV). A 35-year-old male was bitten by a viper at seventeen thirtyhours, and was started on ASV. Two days following treatment he experienced sudden onset redness andpainful diminution of vision in both eyes (OU). On examination, the patient’s visual acuity (VA) in OU was 20/ 200. Examination revealed fresh keratic precipitates, cells, and flare in the anterior chamber (AC), posteriorsynechiae, sluggish and ill-sustained pupillary reaction, and hyperemic, edematous disc with blurredmargins in OU. He was started on topical steroids, cycloplegics and intravenous methylprednisolone. Following treatment, the patient showed improvement and was continued on topical medications and oralprednisolone tapered over 3 weeks, after which VA OU improved, the AC showed no cells and flare anddisc edema resolved. Uveitis and optic disc edema in snake bite can either be due to the direct toxic effectsof the venom or the effect of ASV. Steroids have a beneficial role in the management of these symptoms.

Ocular Manifestations of Venomous Snake Bite over a One-year Period in a Tertiary Care Hospital

Praveen Kumar K V,Praveen Kumar S,Nirupama Kasturi,Shashi Ahuja 대한안과학회 2015 Korean Journal of Ophthalmology Vol.29 No.4

Purpose: Ocular manifestations in snake-bite injuries are quite rare. However, the unusual presentations, diagnosis and their management can pose challenges when they present to the ophthalmologist. Early detection of these treatable conditions can prevent visual loss in these patients who are systemically unstable and are unaware of their ocular condition. To address this, a study was conducted with the aim of identifying the various ocular manifestations of snake bite in a tertiary care center. Methods: This is a one-year institute-based prospective study report of 12 snake bite victims admitted to a tertiary hospital with ocular manifestations between June 2013 to June 2014, which provides data about the demographic characteristics, clinical profiles, ocular manifestations, and their outcomes. Results: Twelve cases of snake bite with ocular manifestations were included of which six were viper bites, three were cobra bites and three were unknown bites. Six patients presented with bilateral acute angle closure glaucoma (50%), two patients had anterior uveitis (16.6%) of which one patient had concomitant optic neuritis. One patient had exudative retinal detachment (8.3%), one patient had thrombocytopenia with subconjunctival hemorrhage (8.3%) and two patients had external ophthalmoplegia (16.6%). Conclusions: Bilateral angle closure glaucoma was the most common ocular manifestation followed by anterior uveitis and external ophthalmoplegia. Snake bite can result in significant ocular morbidity in a majority of patients but spontaneous recovery with anti-snake venom, steroids and conservative management results in good visual prognosis.

Application of Genetic Algorithm in Software Testing

Praveen Ranjan Srivastava,Tai-hoon Kim 보안공학연구지원센터 2009 International Journal of Software Engineering and Vol.3 No.4

Power spectrum density analysis for the influence of complete denture on the brain function of edentulous patients - pilot study

Praveen Perumal,Gopi Naveen Cher,Kuttae Viswanathan Anitha,Jetti Ramesh Reddy,Balasubramanium Muthukumar 대한치과보철학회 2016 The Journal of Advanced Prosthodontics Vol.8 No.3

PURPOSE This pilot study was to find the influence of complete denture on the brain activity and cognitive function of edentulous patients measured through Electroencephalogram (EEG) signals. MATERIALS AND METHODS The study recruited 20 patients aged from 50 to 60 years requiring complete dentures with inclusion and exclusion criteria. The brain function and cognitive function were analyzed with a mental state questionnaire and a 15-minute analysis of power spectral density of EEG alpha waves. The analysis included edentulous phase and post denture insertion adaptive phase, each done before and after chewing. The results obtained were statistically evaluated. RESULTS Power Spectral Density (PSD) values increased from edentulous phase to post denture insertion adaption phase. The data were grouped as edentulous phase before chewing (EEG p1-0.0064), edentulous phase after chewing (EEG p2-0.0073), post denture insertion adaptive phase before chewing (EEG p3-0.0077), and post denture insertion adaptive phase after chewing (EEG p4-0.0096). The acquired values were statistically analyzed using paired t-test, which showed statistically significant results (P<.05). CONCLUSION This pilot study showed functional improvement in brain function of edentulous patients with complete dentures rehabilitation

Numerical Simulation of Capillary Tube for Selected Refrigerants Using Homogeneous Equilibrium Model

Praveen Alok,Debjyoti Sahu 대한설비공학회 2019 International Journal Of Air-Conditioning and Refr Vol.27 No.1

In this work, a set of computational investigation results of two-phase refrigerant flow through adiabatic capillary are presented. There are various sizes of capillary tubes that can be selected related to commercially available copper tubes. Earlier refrigerants and new refrigerants like R12, R22, R134a, R410A and R32 are used for the flow analysis. Homogeneous-equilibrium model is employed with user-defined properties of the refrigerants for computation using ANSYS CFX. Several important parameters can be predicted rapidly and accurately using this method such as refrigerant mass flow rate, vapor mass fraction, local Mach no. etc. The mean deviation in mass flow rate is found to be ∼ ∼ 1.18% for the same length of capillary tube and the mean deviation of tube length is found to be ∼ ∼ 1.48% for the same experimental mass flow rate with choked flow condition.

Influence of supplementary cementitious materials on strength and durability characteristics of concrete

Praveen Kumar, V.V.,Ravi Prasad, D. Techno-Press 2019 Advances in concrete construction Vol.7 No.2

The present study is focused on the mechanical and durability properties of ternary blended cement concrete mix of different grades 30 MPa, 50 MPa and 70 MPa. Three mineral admixtures (fly ash, silica fume and lime sludge) were used as a partial replacement of cement in the preparation of blended concrete mix. The durability of ternary blended cement concrete mix was studied by exposing it to acids HCl and $H_2SO_4$ at 5% concentration. Acid mass loss factors (AMLF), acid strength loss factor (ASLF) and acid durability factor (ADF) were determined, and the results were compared with the control mix. Chloride ions penetration was investigated by conducting rapid chlorination penetration test and accelerated corrosion penetration test on control mix and ternary blended cement concrete. From the results, it was evident that the usage of these mineral admixtures is having a beneficiary role on the strength as well as durability properties. The results inferred that the utilization of these materials as a partial replacement of cement have significantly enhanced the compressive strength of blended concrete mix in 30 MPa, 50 MPa and 70 MPa by 42.95%, 32.48% and 22.79%. The blended concrete mix shown greater resistance to acid attack compared to control mix concrete. Chloride ion ingress of the blended cement concrete mix was low compared to control mix implying the beneficiary role of mineral admixtures.

Disturbance due to internal heat source in thermoelastic solid using dual phase lag model

Praveen Ailawalia,Amit Singla 국제구조공학회 2015 Structural Engineering and Mechanics, An Int'l Jou Vol.56 No.3

The dual-phase lag heat transfer model is employed to study the problem of isotropic generalized thermoelastic medium with internal heat source. The normal mode analysis is used to obtain the exact expressions for displacement components, force stress and temperature distribution. The variations of the considered variables through the horizontal distance are illustrated graphically. The results are discussed and depicted graphically.

In vitro and in vivo evaluation of gastro-retentive carvedilol loaded chitosan beads using Gastroplus(TM)

Praveen, R.,Prasad Verma, P.R.,Venkatesan, J.,Yoon, D.H.,Kim, S.K.,Singh, S.K. ELSEVIER 2017 INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES Vol.102 No.-

The objective of present investigation was to develop gastro-retentive controlled release system of carvedilol using biological macromolecule, chitosan. 3<SUP>2</SUP> full factorial design was adopted for optimization of tripolyphosphate (X<SUB>1</SUB>) and curing time (X<SUB>2</SUB>). Bead stability in 0.1N HCl, buoyancy duration, density, drug loading, dissolution efficiency and cumulative percentage release at 8th hour were evaluated as dependent variables. The levels of X<SUB>1</SUB> and X<SUB>2</SUB> of optimized formulation having maximum desirability was found to 2.0% w/v and 62.66min, respectively. The in silico predicted responses and observed response were found to be in good agreement (percent bias error: -13.295 to +13.269). SEM images showed numerous pores in the cross sectional image that renders buoyancy. AUC<SUB>0-~</SUB> of optimized formulation was 1.47 times higher as compared to suspension corroborating enhanced extent of absorption. T<SUB>max</SUB> and mean residence time were significantly higher from optimized formulation vis a vis suspension. In silico study indicated maximum regional absorption from the duodenum (94.1%) followed by jejunum (5.6%). Wagner-Nelson and Loo-Reigelman method were the preferred deconvolution approach over numerical deconvolution to establish IVIVC. In conclusion, the study showed that gastro-retentive controlled release system prepared using chitosan could be a potential drug carrier of carvedilol with improved bioavailability.

Pharmacokinetic evaluation of cefdinir-loaded floating alginate beads in rabbits using LC–MS/MS

Praveen R,Sandeep Kumar Singh,Priya Ranjan Prasad Verma 한국약제학회 2016 Journal of Pharmaceutical Investigation Vol.46 No.3

The present investigation aims to compare the pharmacokinetic parameters of Cefdinir in rabbits, from floating alginate (an anionic polysaccharide obtained from cell walls of brown algae) beads and conventional suspension, using a new LC–MS/MS method. Formulations equivalent to 20 mg/kg were administered orally to test and reference group and blood samples were collected at selected time intervals up to 24 h. Plasma concentrations of Cefdinir were determined using validated LC–MS/MS method and pharmacokinetic parameters were derived by non-compartment model. Statistically significant (p\0.05) increase in Cmax, Tmax, AUC0–? and MRT was observed in case of floating alginate beads, whereas KE and t1/2 remained relatively constant. MRT and tmax increased significantly as a result of controlled drug release. Relative bioavailability was 337.45 % for the floating beads. Thus, alginate based floating formulation improve the bioavailability (3.37 fold) of Cefdinir compared to suspension. The absorption of Cefdinir from floating beads was found mainly from duodenum (73.0 %) and Jejunum 1 and 2 (13.0 %).

Comparative study on magnetic field generation to navigate the micro-robot generated using Helmholtz coil

Praveen Kumar(프라빈 쿠마르),Seoksoon Lee(이속순) 항공우주시스템공학회 2017 항공우주시스템공학회 학술대회 발표집 Vol.2017 No.4