Poster Session : PS 0051 ; Cardiology : Albuminuria During Acute Myocardial Infarction; A Strong Predictor for Short Term Mortality in Acute Coronary Syndrome

( Prahlad Karki ),( Hemant Shrestha ),( Pramod Acharya ),( Nikesh Shrestha ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: Studies have shown that albuminuria is associated with increased risk of morbidity and mortality after an attack of acute coronary syndrome than non-albuminuric patients. Objective: To see the occurrence of albuminuria and its prognostic signifi cance for short term outcome during hospital stay in Acute coronary syndrome. Methods: Albuminuria was measured as urinary albumin to creatinine ratio on fi rst day of admission, and divided into three categories; normoalbuminuria (M0): 30mg/ gm, microalbuminuria (M1): 30-300mg/gm, macroalbuminuria (M2): 300mg/gm. Sample size of 124 was calculated with frequency of albuminuria of 30% in ACS (CI: 95%, alpha error-0.05, power of study = 80% i.e. beta error = 0.2 and odds ratio between case and control group- 3). Patients were monitored and followed up closely during hospital stay. Results: One hundred and seventeen (117) patients out of 134 enrolled had albuminuria (87%; M1:93, M2:24). Patients presenting with blood sugar of 140 mg/dl had signifi cantly high albuminuria. The complications were more in patients with albuminuria than those with normoalbuminuria (p=0.02). Complications increased as the level of albuminuria increased with highest in macroalbuminuric group (p=0.005). In multivariate analysis, the variables which signifi cantly affected the outcome were systolic blood pressure 140 mmHg, smoking, type 2 diabetes mellitus and age > 65 years. Though albuminuria was not signifi cant variable in multivariate analysis, it showed tendency to develop complications (OR - 3.28, 95% CI: 0.95-11.4). Total leucocyte count 11,000/ mm3, type 2 diabetes mellitus, smoking, and albuminuria were found to be associated with signifi cantly increased mortality after Acute coronary syndrome. Conclusion: Albuminuria is a useful variable for predicting short term outcome. It may provide simple assessment tools for predicting outcome in ACS in resource poor settings if validated further.

A Novel Image Thresholding for Infrared Thermal Image Segmentation

Hyun, Dai Joon Manda, Manikanta Prahlad 청주대학교 산업과학연구소 2022 産業科學硏究 Vol.39 No.2

Image thresholding is one of the popular approaches for image segmentation. Traditional thresholding methods face challenges in finding the optimal threshold value for infrared thermal image thresholding. In this paper, we propose a new approach to find the optimal threshold value for infrared thermal image segmentation. Creating a criterion function model using the one-dimensional histogram information of the image to get the possible object and background region separations in the image is the primary objective of the proposed method. For that, a cumulative probability distribution dependent iterative model is developed. Thereafter, a mathematical model based on sine function is utilized to extract an optimal threshold value for two-level infrared thermal image segmentation. We have experimented with our method on several infrared thermal images collected from standard image databases to describe the performance, and they are compared to the state-of-the-art methods to interpret the ability of the proposed method. 이미지 임계방법은 이미지 분리에 사용되는 가장 단순하면서도 널리 사용되는 방법이다. 그러나 전통적인 이미지 임계방법은 적외선 열 이미지에 대해서는 낮은 정확도를 가진다. 이 논문에서 우리는 적외선 열 이미지에 대한 최적의 임계값을 찾는 새로운 방법을 제안하고자 한다. 이 문제는 주어진 이미지의 회색조 히스토그램에서 기준 함수를 구하고 그로부터 이미지의 물체와 배경을 분리하는 것을 목적으로 가진다. 이를 위해 우리는 누적확률분포 기반의 반복적인 이미지 임계방법이 제안한다. 제안 방법에서는 사인 함수에 기반한 수학적인 모델이 최적의 임계값을 추출하는데 사용된다. 제안방법은 많은 수의 적외선 열 이미지 분리에 적용되고 최신 연구들의 결과들과 비교, 평가된다.

Poster Session:PS 0194 ; Endocrinology : Increased Serum Hs-Crp Level in Conjunction with Other Cardiovascular Risk Factors in Subclinical Hypothyroidism

( Rajendra Kc ),( Madhab Lamsal ),( Prahlad Karki ),( Shankar Majhi ),( Nirmal Baral ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: Several potential cardiovascular risk factors were reported in patients with subclinical hypothyroidism (SCH) but the association still remains controversial therefore, we aimed to evaluate cardiovascular risk factors in subjects with subclinical hypothyroidism. Methods: A total of 100 subjects with subclinical hypothyroidism and 100 age and gender matched euthyroid controls, were included in the study. Serum free T3, free T4 and TSH were estimated by fl uorescent immunoassay. Total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) were assayed by enzymatic colorimetric method, and high sensitivity C-reactive protein (hs-CRP) by enzyme immunoassay. Data were analyzed by SPSS version 20. Results: Mean levels of diastolic blood pressure (82.1±6.0 vs 79.1±6.1 mmHg, p=0.001), total cholesterol (199.6±31.6 vs 184.3±30.8 mg/dl, p=0.001) and LDL-C (104.0±27.5 vs 94.6±25.4, p=0.012), and median hs-CRP (0.92 (0.30-2.17) vs 0.56 (0.33-1.35), p=0.03) were significantly higher in SCH than the euthyroids. Within the SCH group, mean diastolic blood pressure, TC, LDL-C, and median hs-CRP levels were signifi cantly higher in subjects with TSH=10 mU/L than those with TSH<10 mU/ L. Individual analysis revealed that the prevalence of borderline elevated total cholesterol (=200mg/dL), elevated LDL-C (=100mg/dL) and raised hs-CRP (=3mg/L) were signifi cantly higher in SCH than ineuthyroid group. TSH levels in SCH was positively correlated with diastolic blood pressure (r=0.33, p=0.001), total cholesterol (r=0.39, p<0.001), LDL-C (r=0.42, p<0.001) and hs-CRP (r=0.51, p<0.001). Conclusions: Subclinical hypothyroidism was associated with higher diastolic blood pressure, higher total cholesterol, LDL-C and higher hs-CRP levels, this might increase the risk of accelerated arteriosclerosis.

Polymer-Based Flexible Visuo-Haptic Display

Sungryul Yun,Suntak Park,Bongjae Park,Seung Koo Park,Prahlad, Harsha,Von Guggenberg, Philip,Ki-Uk Kyung IEEE 2014 IEEE/ASME transactions on mechatronics Vol.19 No.4

<P>We report a flexible visuo-haptic display that allows for interactive haptic feedback on the visual display. The visuo-haptic display is fabricated by integrating a dielectric elastomer (DE) based thin film actuator array into a flexible display and pressure sensors. The DE actuator array consists of nine active cells, which generate thickness-mode deformation in response to voltage signal. The flexible display presents images of the aligned three alphabet characters at each section in 3 × 3 matrix during light propagation via optical multiwaveguide. The pressure sensors are placed on the bottom of the DE actuator array for haptic feedback. The performance of the DE actuators is proved to be capable of realizing sufficient vibro-tactile sensation in the perceivable range of human touch sense. The integrated system enables the visual display to provide interactive haptic feedback such as key pressing, contact vibration sensations, etc., in accordance with user input.</P>

Flexible Visio-Haptic Display

Kyung, K.-U.,Lee, J.-u.,Park, S.,Prahlad, H.,von Guggenberg, P. SPRINGER-VERLAG 2012 Lecture Notes in Computer Science Vol.7283 No.-

Molecular-based identification and phylogeny of genomic and proteomic sequences of mosquito-borne flavivirus

Sunil Kumar Gupta,Sarita Singh,Anuradha Nischal,Kamlesh Kumar Pant,Prahlad Kishore Seth 한국유전학회 2014 Genes & Genomics Vol.36 No.1

Mosquito-borne flaviviruses (MBFVs) areimportant cause of emerging and re-emerging human diseasesnearly worldwide, transmitted by arthropod vectors(mostly aedes and culex mosquitoes), with particular referenceto yellow fever virus, Japanese encephalitis virus,dengue fever virus, St. Louis encephalitis virus, MurrayValley encephalitis virus, etc. In over 100 countries, morethan 2.5 billion people are at risk of infection, andapproximately 20 million infections are reported annually. Through the analysis of gene sequence data of these viruspopulations it is possible to infer phylogenetic relationships,which in turn can yield important epidemiologicalinformation, including their demographic history. Earlyattempts to define the evolutionary relationships and originsof viruses in the genus flavivirus are hampered by thelack of genetic information particularly amongst theMBFVs. In this study, complete genome, translated polyprotein,structural and non-structural proteins of MBFVshave been targeted and revealed an extensive series ofclades defined by their epidemiology and disease associations. The branching patterns of at the deeper nodes of theresultant trees were different from those reported in theprevious study. The significance of these observations isdiscussed.

Poster Session:PS 0233 ; Gastroenterology : Alcoholic Liver Disease in Nepal: Identifying Home- Made Alcohol as Culprit

( Bickram Pradhan ),( Antoine Hadengue ),( Shatdal Chaudhary ),( Francois Chappuis ),( Dharanidhar Baral ),( Pascal Gache ),( Prahlad Karki ),( Suman Rijal ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: Though the type of alcohol consumed is not thought to be associated with Alcoholic Liver Disease (ALD), some studies have shown a beverage specifi c effect. The prevalence of alcohol use disorders (AUD) is very high in Nepal due to easy availability of cheap locally brewed alcoholic beverages. In the present study we aim to detect the prevalence of ALD in patients with AUD and to study the effects of the different types of alcoholic beverages on the liver. Methods: This cross-sectional study was conducted in the internal Medicine department of a tertiary care center in Nepal. All patients classifi ed as having either alcohol abuse or alcohol dependence by DSM IV were evaluated for presence of ALD. Results: A total 1332 patients were screened of which 447 patients (292 males and 155 females) had AUD. Chronic liver disease (CLD) was detected in 144 patients (10.8%). Most of the patients consumed home made locally brewed alcohol like chhang (62%), rakshi (77%) and tongba(16.3%). On multivariate analysis the following variables were found to be signifi cantly associated with CLD: Male sex (OR 1.81, 95% CI [1.12-2.94] p value 0.02): rakshi consumption = 30 units (OR 2.53, 95% CI [1.07-6.01] p value 0.04): togba consumption (OR 3.02, 95% CI [1.22-7.50] p value 0.02 Conclusions: There was a signifi cant increase in the risk of developing ALD with the consumption of rakshi and tongba after adjusting for total unit consumed. The absence of striking differences between our patients with CLD and non-CLD patients as regards the amount of alcohol consumed demonstrates that, although alcohol consumption is a pre-requisite for the development of ALD, other factors like type of alcoholic beverage consumed may be involved.

열화상카메라와 하드웨어 가속기를 이용한 고온 특징점 추출 연구

오병철(ByeongCheol Oh),박찬수(Chan Su Park),마니칸타 프라할라드 만다(Manikanta Prahlad Manda),김희석(Hi Seok Kim) 한국정보기술학회 2019 Proceedings of KIIT Conference Vol.2019 No.6

Evaluation of Anti Nutritional Factors in Fungal Fermented Cereals

Minakshee Dwivedi,Vasantha Kuntavalli Yajnanarayana,Manjeet Kaur,Avinash Prahlad Sattur 한국식품과학회 2015 Food Science and Biotechnology Vol.24 No.6

Cereals and legumes are rich in minerals, but the bioavailability of these minerals is usually low due to the presence of anti-nutritional factors, such as phytate, trypsin inhibitors, and tannin. Reductions in the influence of these factors is necessary to derive the full nutritive value of cereals and grains. Penicillium camemberti was grown on millets (kodo millet and proso millet) and legumes (moth beans and cow peas). Fermented grains were analyzed for the influence of anti-nutritional factors. Fermentation reduced the phytic acid content in proso millets. The tannin contents were reduced in both moth beans and cow peas while there were reductions of 38.3% and 74.3% in alkaloid contents in fermented moth beans and cowpeas. The trypsin inhibitor contents also decreased in all legumes and millets after solid state fermentation.

필름형 유연 시-촉각 융합 디스플레이

윤성률(Sungryul Yun),박선택(Suntak Park),박봉제(Bongje Park),박승구(Seung Koo Park),남세광(Saekwang Nam),경기욱(Ki-Uk Kyung),Harsha Prahlad,Philip von Guggenberg 한국로봇학회(논문지) 2013 로봇학회 논문지 Vol.8 No.3