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Dancing Feet Dyskinesia in a Patient with GBA-PD
Diana A. Olszewska,Allan McCarthy,Alexandra I. Soto-Beasley,Ronald L. Walton,Owen A. Ross,Tim Lynch 대한파킨슨병및이상운동질환학회 2022 Journal Of Movement Disorders Vol.15 No.1
Dancing-like dyskinesia has been reported as part of a phenotype associated with pathogenic variants in the parkin gene responsible for autosomal-recessive Parkinson’s disease (PD) [1]. Parkin variants cause early-onset PD (EOPD, < age 50), with slow disease progression, sensitivity to levodopa, and frequent dystonia
Łucja Łaniewska-Trokenheim,Magdalena Olszewska,Marta Mikš-Krajnik,Anna Zadernowska 한국미생물학회 2010 The journal of microbiology Vol.48 No.4
The focus of this study was to monitor the survival of populations and the volatile compound profiles of selected Lactobacillus strains during long-term incubation in milk. The enumeration of cells was determined by both the Direct Epifluorescent Filter Technique using carboxyfluorescein diacetate (CFDA) staining and the plate method. Volatile compounds were analysed by the gas-chromatography technique. All strains exhibited good survival in cultured milks, but Lactobacillus crispatus L800 was the only strain with comparable growth and viability in milk, assessed by plate and epifluorescence methods. The significant differences in cell numbers between plate and microscopic counts were obtained for L. acidophilus strains. The investigated strains exhibited different metabolic profiles. Depending on the strain used, 3 to 8 compounds were produced. The strains produced significantly higher concentrations of acetic acid, compared to other volatiles. Lactobacillus strains differed from one another in number and contents of the volatile compounds.
Borawska, M.H.,Czechowska, S.K.,Markiewicz, R.,Hayirli, A.,Olszewska, E.,Kazim Sahin, D.V.M The Korean Society of Food Science and Nutrition 2009 Journal of medicinal food Vol.12 No.2
The effects of lycopene, genistein, and epigallocatechin-3-gallate (EGCG) on cell viability were tested in vitro using a normal human skin fibroblast (NHSF) cell line (CRL-1474) and granulation tissue fibroblasts (GTFs) obtained from a patient with middle ear cholesteatoma. Cell cultures were added with lycopene (1, 5, and $10\;{\mu}M$), genistein (1, 5, 10, 25, and $50\;{\mu}M$), and EGCG (1, 5, 10, 25, and $50\;{\mu}M$) and their respective control cultures were established by adding 5 mL/L tetrahydrofuran (THF), 5 mL/L dimethyl sulfoxide (DMSO), and 5 mL/L DMSO. A colorimetric assay was employed for determining cell viability using thiazolyl blue tetrazolium bromide. Cell viability was expressed as a percentage of the control. Data were analyzed using two-way analysis of variance separately for each compound. Lycopene addition decreased viability of NHSFs and GTFs compared with THF addition (64.1%, 60.5%, and 100%, respectively, P < .0001). Genistein addition also increased viability of both NHSFs and GTFs compared with DMSO addition (P < .02). Increasing EGCG concentration tended to cause a linear increase in viability of NHSFs but did not alter viability of GTFs (P < .10). Our data suggest that genistein and EGCG but not lycopene could help maintaining or improving skin health through enhancing viability of skin fibroblasts.
M.H. Borawska,S.K. Czechowska,R. Markiewicz,A. Hayirli,E. Olszewska,K. Sahin 한국식품영양과학회 2009 Journal of medicinal food Vol.12 No.2
The effects of lycopene, genistein, and epigallocatechin-3-gallate (EGCG) on cell viability were tested in vitro using a normal human skin fibroblast (NHSF) cell line (CRL-1474) and granulation tissue fibroblasts (GTFs) obtained from a patient with middle ear cholesteatoma. Cell cultures were added with lycopene (1, 5, and 10 μM), genistein (1, 5, 10, 25, and 50 μM), and EGCG (1, 5, 10, 25, and 50 μM) and their respective control cultures were established by adding 5 mL/L tetrahydrofuran (THF), 5 mL/L dimethyl sulfoxide (DMSO), and 5 mL/L DMSO. A colorimetric assay was employed for determining cell viability using thiazolyl blue tetrazolium bromide. Cell viability was expressed as a percentage of the control. Data were analyzed using two-way analysis of variance separately for each compound. Lycopene addition decreased viability of NHSFs and GTFs compared with THF addition (64.1%, 60.5%, and 100%, respectively, P < .0001). Genistein addition also increased viability of both NHSFs and GTFs compared with DMSO addition (P < .02). Increasing EGCG concentration tended to cause a linear increase in viability of NHSFs but did not alter viability of GTFs (P < .10). Our data suggest that genistein and EGCG but not lycopene could help maintaining or improving skin health through enhancing viability of skin fibroblasts.
Sulowski Maciej,Cias Andrzej,Frydrych Hanna,Frydrych Jerzy,Olszewska Irena,Golen Ryszard,Sowa Marek 한국분말야금학회 2006 한국분말야금학회 학술대회논문집 Vol.2006 No.1
The effect of different cooling rate on the structure and mechanical properties of Fe-3%Mn-(Cr)-(Mo)-0.3%C steels is described. Pre-alloyed Astaloy CrM and CrL, ferromanganese and graphite were used as the starting powders. Following pressing in a rigid die, compacts were sintered at and in atmospheres and cooled with cooling rates and . Convective cooled specimens were subsequently tempered at for 60 and 240 minutes.