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FIXED POINT SOLUTION METHODS FOR SOLVING EQUILIBRIUM PROBLEMS
Anh, Pham Ngoc,Hien, Nguyen Duc Korean Mathematical Society 2014 대한수학회보 Vol.51 No.2
In this paper, we propose new iteration methods for finding a common point of the solution set of a pseudomonotone equilibrium problem and the solution set of a monotone equilibrium problem. The methods are based on both the extragradient-type method and the viscosity approximation method. We obtain weak convergence theorems for the sequences generated by these methods in a real Hilbert space.
Anh Thu Ngoc Lam,윤진하,Nguyen Hoang Ly,주상우 한국바이오칩학회 2018 BioChip Journal Vol.12 No.2
The nanodiamond (ND) conjugates of gefitinib (GF) and erlotinib (EL) were assembled for in vitro lung cancer treatments. The carboxylate infrared bands along with the negative surface charge of -28.3 (±2.1) mV were found efficient to conjugate the nitrogen- containing quinazoline ring drugs, due to the electrostatic interactions, resulting from the surface changes to -12.0 (±1.2) mV and -9.1 (±1.2) mV after adsorption of GF and EL on NDs, respectively. The physicochemical properties of NDs were characterized by transmission electron microcopy, X-ray diffraction, X-ray photoelectron, infrared and Raman spectroscopic tools. The size distributions of NDs after the self-assembly of GF and EL could be checked by dynamic light scattering measurements. The uptake of NDs in cancer cells was estimated by fluorescence microscopy. Cell viability appeared to decrease by 30-50% at 50 and 100 nM of GF and EL, respectively, after the treatment of PEG-assembled NDs compared to the cases using free drugs. Our ND conjugates may be potentially useful for overcoming the chemoresistances in lung cancer cells.
Distribution of Factors Affecting Foreign Direct Investment in ASEAN Countries
Anh Thi Lan NGUYEN(Anh Thi Lan NGUYEN ),Chau Thi Minh PHAM(Chau Thi Minh PHAM ),Hanh Hong NGUYEN(Hanh Hong NGUYEN ),Dat Ngoc NGUYEN(Dat Ngoc NGUYEN ),Duy Van NGUYEN(Duy Van NGUYEN ) 한국유통과학회 2023 유통과학연구 Vol.21 No.2
Purpose: Research on attracting foreign direct investment plays an important role in ASEAN countries. ASEAN has needed FDI capital for development and integration with many developing countries. Research design, data and methodology: This study is conducted to assess the impact of factors: inflation (INF), economic growth (GDP), population (POP), and trade (TRADE) on attracting foreign direct investment (FDI) of ASEAN countries. The study will find out how factors distribution contributes to FDI attraction. The study collects data from 10 ASEAN countries from 2010 to 2020. With data collected for ten countries from 2010 to 2020, data analysis with panel data will be used in this study. The Regression with Driscoll-Kraay standard errors correction model will be used in the study. Results: Panel data analysis shows that economic growth and population positively impact FDI attraction in ASEAN countries. However, two factors: INF and TRADE, do not affect FDI. Conclusions: Countries need to focus on economic development, create many good conditions for people and domestic enterprises and create opportunities for foreign investors to pay more attention. improving the quality of domestic human resources will help to better improve the working quality factor when the demand for high-quality human resources increases.
Biocatalytic Production of 3-OH Phlorizin by CYP102A1 via Regioselective Hydroxylation
Ngoc Anh NGUYEN,Ngoc Tan CAO,Jeong-Hoon KIM,Chul-Ho YUN 한국생물공학회 2021 한국생물공학회 학술대회 Vol.2021 No.10
Phlorizin and its aglycone phloretin from the apple tree and its products are currently considered health-beneficial polyphenols from apples useful in treating hyperglycemia and obesity. Recently, we showed that phloretin can be regioselectively hydroxylated to make 3-OH phloretin by Bacillus megaterium CYP102A1 and human P450 enzymes. The 3-OH phloretin has a potent inhibitory effect on differentiating 3T3-L1 preadipocytes into adipocytes and lipid accumulation. The glucoside of 3-OH phloretin would be a promising agent with increased bioavailability and water solubility compared with its aglycone. However, procedures to make 3-OH phlorizin using chemical methods are not currently available. Here, a biocatalytic strategy for the efficient synthesis of a possibly valuable hydroxylated product was developed via CYP102A1-catalyzed regioselective hydroxylation. The production of 3-OH phlorizin by CYP102A1 was confirmed by HPLC and LC-MS spectroscopy in addition to enzymatic removal of its glucose moiety. Taken together, we found a panel of mutants from B. megaterium CYP102A1 can catalyze regioselective hydroxylation of phlorizin to produce 3-OH phlorizin, a catechol product.
Ngoc Tan CAO,Ngoc Anh NGUYEN,Chan-Mi PARK,Chul-Ho YUN 한국생물공학회 2021 한국생물공학회 학술대회 Vol.2021 No.10
Statins inhibit the 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMG-CoA reductase), which plays a central role in the cholesterol production. They reduce cardiovascular disease and mortality in those who are at high risk of cardiovascular disease. Monacolin J is a statin compound as a lovastatin precursor. It is found in red yeast rice with various strains of the yeast Monascus purpureus. Monacolin J has a hydroxyl substituent at position C’-8 of monacolin L. This study was conducted to synthesize new statin compounds from monacolin J through bacterial CYP102A1 catalysis. Here we found the catalytic ability of CYP102A1 to catalyze regioselective hydroxylation of monacolin J. More specifically, a major product was found with a hydroxyl group attached at C-6’a position of monacolin J, which has never been reported. C-6’a-hydroxymethyl monacolin J has shown the ability to inhibit HMG-CoA reductase higher than the monacolin J substrate itself. Human liver microsomes and human CYP3A4 also showed the ability to catalyze monacolin J to produce the same product of CYP102A1-catalyzed reaction. This result will be a premise as a new platform for development of statin drug candidates.