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RISS 인기검색어
- 검색키워드
- 저자 : Naveen Prasad (검색결과 5 건)
- 무료
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Generation of Monodisperse Inorganic–Organic Janus Microspheres in a Microfluidic Device
Prasad, Naveen,Perumal, Jayakumar,Choi, Chang-Hyung,Lee, Chang-Soo,Kim, Dong-Pyo WILEY-VCH Verlag 2009 Advanced Functional Materials Vol.19 No.10
<P>This study presents a simple synthetic approach for the in situ preparation of monodisperse hybrid Janus microspheres (HJM) having organic and inorganic parts in a PDMS-based microfluidic device. Based on the mechanism of shear-force-driven break-off, merged droplets of two photocurable oligomer solutions having distinctive properties are generated into an immiscible continuous phase. Functionalized perfluoropolyether (PFPE) as the organic phase and hydrolytic allylhydridopolycarbosilane (AHPCS) as the inorganic phase are used for the generation in aqueous medium of HJM with well-defined morphology and high monodispersity (average diameter of 162 µm and a 3.5% coefficient of variation). The size and shape of the HJM is controlled by varying the flow rate of the disperse and continuous phases. The HJM have two distinctive regions: a hydrophobic hemisphere (PFPE) having a smooth surface and a relatively hydrophilic region (AHPCS) with a rough, porous surface. In addition, pyrolysis and subsequent oxidation of these HJM convert them into SiC-based ceramic hemispheres through the removal of the organic portion and etching off the silica shell. The selective incorporation of magnetic nanoparticles into the inorganic part shows the feasibility of the forced assembly of HJM in an applied magnetic field.</P> <B>Graphic Abstract</B> <P>Monodisperse hybrid microspheres (HJM) having organic and inorganic parts are prepared in a PDMS-based microfluidic device. The HJM have two distinct regions: a hydrophobic perfluoropolyether hemisphere and a relatively hydrophilic polycarbosilane region. After pyrolysis and subsequent oxidation, a SiC-based ceramic hemisphere (see image) is obtained by means of decomposition of the organic portion. <img src='wiley_img/1616301X-2009-19-10-ADFM200801181-content.gif' alt='wiley_img/1616301X-2009-19-10-ADFM200801181-content'> </P>
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Nitric oxide suppresses L-type calcium currents in basilar artery smooth muscle cells in rabbits
Sharma, Naveen,Bhattarai, Janardhan Prasad,Hwang, Pyoung Han,Han, Seong Kyu Informa UK (TaylorFrancis) 2013 Neurological research Vol.35 No.4
<P>Nitric oxide (NO) is well known to be a vasodilator, and NO donor compounds are currently used for treating vasospasm following subarachnoid hemorrhage. However, the action mechanism of cerebral vascular relaxation is not yet clear. L-type calcium channels have been determined to play an essential role in smooth muscle contraction. To investigate the role of L-type calcium channels in NO-induced relaxation of basilar smooth muscle cells, we examined the effect of the NO donor, sodium nitroprusside (SNP) on calcium (Ca2+) currents using smooth muscle cells isolated from a rabbit basilar artery.</P>
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최창형,Naveen Prasad,이내림,이창수 한국바이오칩학회 2008 BioChip Journal Vol.2 No.1
This study is an experimental investigation of a microfluidic method for the formation of droplets and mixing efficiency in continuous microfluidic channels. Droplet size strongly depends on the total aqueous flow rate under a fixed oil flow rate. In the case of different wetting properties, a hydrophobically homogeneous microfluidic channel produces smaller droplets than that of a heterogeneous microfluidic channel b ecause of the different wettability of the formed aqueous droplets. However, high mixing efficiency in the two types of microfluidic channel is achieved by droplet recirculation. Although an increase in droplet size demands a longer mixing time, the microfluidic approach provides rapid mixing and no reagent dispersion. This mixing method in microfluidics can be applied to a variety of chemical syntheses or biochemical reactions at the nanoliter scale. This study is an experimental investigation of a microfluidic method for the formation of droplets and mixing efficiency in continuous microfluidic channels. Droplet size strongly depends on the total aqueous flow rate under a fixed oil flow rate. In the case of different wetting properties, a hydrophobically homogeneous microfluidic channel produces smaller droplets than that of a heterogeneous microfluidic channel b ecause of the different wettability of the formed aqueous droplets. However, high mixing efficiency in the two types of microfluidic channel is achieved by droplet recirculation. Although an increase in droplet size demands a longer mixing time, the microfluidic approach provides rapid mixing and no reagent dispersion. This mixing method in microfluidics can be applied to a variety of chemical syntheses or biochemical reactions at the nanoliter scale.
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Sharma, Naveen,Cho, Dong Hyu,Kim, Sun Young,Bhattarai, Janardhan Prasad,Hwang, Pyoung Han,Han, Seong Kyu Informa UK (TaylorFrancis) 2012 Neurological research Vol.34 No.3
<P>Although magnesium is a well-known treatment for vasospasm following subarachnoid hemorrhage, its mechanism of action for cerebral vascular relaxation is not clear. In addition, it is known that L-type calcium (Ca(2+)) channels play a pivotal role in smooth muscle contraction. To investigate the role of L-type Ca(2+) channels in the magnesium-induced relaxation of basilar smooth muscle cells, we examined the effect of magnesium sulfate on L-type Ca(2+) currents using freshly isolated smooth muscle cells from rabbit basilar arteries.</P>
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Manisha H.,Velayudham M.,Kumara B. N.,Naveen M. H.,Shim Yoon-Bo,Prasad K. Sudhakara 한국탄소학회 2023 Carbon Letters Vol.33 No.3
The rapid synthesis techniques and interesting multidisciplinary applications make carbon nanodots (CNDs) stand out from semiconductor quantum dots. Moreover, CNDs derived from green precursors have gained more importance beyond chemically derived CNDs due to sustainable synthesis opportunities. However, the presence of molecular impurities or intermediates or fluorophores was neglected during the entire process. Herein, we illustrate the sustainable synthesis of CNDs from Hemigraphis alternata plant leaves with extended carbonization procedure (3 and 9 min) along with simultaneous ethylene glycol and diethyl ether solvent treatment method for the successful removal of interfering fluorophores. To unravel the distinction between purified CNDs (P-CNDs) and organic fluorescent carbon nanostructures (org-FCNs), we carried out photophysical, structural, and morphological studies. A quantum yield (QY) of 69 and 42% was observed for crude org-FCNs, and crude P-CNDs; however after purification, QY of 1% and absence of one component from the fluorescent decays curve suggest the removal of fluorophores. Further, HR-TEM and DLS studies showed the quasi-spherical amorphous particles having < 10 nm particle size for P-CNDs. Besides, in vitro biocompatibility investigation and cellular uptake assay (1–100 μg/mL) against the MDA-MB 468 cell lines proves the ≥ 95% cell viability and good internalization for both org-FCNs and P-CNDs. Hence, our study shows the presence of fluorophore impurities in plant-derived CNDs, the removal and resemblance in biocompatibility properties. Hence, this information can be considered during the synthesis and isolation of CNDs.
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