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RISS 인기검색어
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- 저자 : Naser Karimi (검색결과 5 건)
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Aidy Ali,Karimi Elahe,Ghaneialvar Hori,Mohammadpour Shahram,Abbasi Naser 경희대학교 융합한의과학연구소 2020 Oriental Pharmacy and Experimental Medicine Vol.20 No.3
Hepatoxicity is a common complication of acetaminophen. This study was to evaluate the effects of Nectaroscordum tripedale extract (NTE) and its bioactive component tetramethylpyrazine (TMP) on acetaminophen-induced liver failure. The presence of TMP in NTE was determined by HPLC. The hepatoprotective effect of NTE and TMP (50, 100 and 200 mg/kg, respectively) was evaluated by the assay of liver function parameters; total bilirubin, alanine aminotransaminase (ALT), aspartate aminotransaminase (AST), alkaline phosphatase activities (ALP) and superoxide dismutase (SOD). Results revealed that TMP was 1.24 mg/g in NTE. LD50 of the NTE and TMP was 3800 mg/kg and 2700 mg/kg, respectively. NTE and TMP (100 and 200 mg/kg) decreased the ALT, AST, ALP, and bilirubin but the SOD increased in a dose-dependent manner in acetaminophen-induced liver failure rats. In conclusion, NTE and its fraction TMP may be a protecting liver candidate against acetaminophen-induced hepatotoxicity.
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Mehran Alavi,Naser Karimi,Iraj Salimikia 한국공업화학회 2019 Journal of Industrial and Engineering Chemistry Vol.72 No.-
It was used green biosynthesized zinc oxide (ZnO) NPs (average diameter of 50–60 nm) with abilities of antibacterial against sensetive and MDR bacteria including Escherichia coli ATCC 25922, Serratia marcescens ATCC13880, Pseudomonas aeruginosa ATCC 27853 (gram negative), and Staphylococcus aureus ATCC 43300 and Staphylococcus epidermidis ATCC 12258 (gram positive). High reduction in biofilm formation was 63.43% (0.562 ± 0.015) and 62.88% (0.582 ± 0.025) at 100 μg/mL concentration against control for S. epidermidis and P. aeruginosa respectively. In conclusion, this investigation illustrated simple green synthesis of ZnO NPs with suitable advantages of antioxidant, antibacterial, anti-biofilm, anti-QS activities, and also anti-swarming motility against MDR bacteria.
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Mercedeh Tajbakhsh,Abdollah Karimi,Abolghasem Tohidpour,Naser Abbasi,Fatemeh Fallah,Maziar Mohammad Akhavan 한국미생물학회 2018 The journal of microbiology Vol.56 No.2
Cathelicidins are a family of antimicrobial peptides which exhibit broad antimicrobial activities against antibiotic-resistant bacteria. Considering the progressive antibiotic resistance, cathelicidin is a candidate for use as an alternative approach to treat and overcome the challenge of antimicrobial resistance. Cathelicidin-BF (Cath-BF) is a short antimicrobial peptide, which was originally extracted from the venom of Bungarus fasciatus. Recent studies have reported that Cath-BF and some related derivatives exert strong antimicrobial and weak hemolytic properties. This study investigates the bactericidal and cytotoxic effects of Cath-BF and its analogs (Cath-A and Cath-B). Cath-A and Cath-B were designed to increase their net positive charge, to have more activity against methicillin resistant S. aureus (MRSA). The results of this study show that Cath-A, with a +17-net charge, has the most noteworthy antimicrobial activity against MRSA strains, with minimum inhibitory concentration (MIC) ranging between 32–128 μg/ml. The bacterial kinetic analysis by 1 × MIC concentration of each peptide shows that Cath-A neutralizes the clinical MRSA isolate for 60 min. The present data support the notion that increasing the positive net charge of antimicrobial peptides can increase their potential antimicrobial activity. Cath-A also displayed the weakest cytotoxicity effect against human umbilical vein endothelial and H9c2 rat cardiomyoblast cell lines. Analysis of the hemolytic activity reveals that all three peptides exhibit minor hemolytic activity against human erythrocytes at concentrations up to 250 μg/ml. Altogether, these results suggest that Cath-A and Cath-B are competent candidates as novel antimicrobial compounds against MRSA and possibly other multidrug resistant bacteria.
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Ghafour Ahmad Khanbeigi,Gholamreza Jahanfarnia,Naser Mansour Sharifloo,Mohamad Kazem Sheikh-el-Eslami,Kaveh Karimi 대한전기학회 2020 Journal of Electrical Engineering & Technology Vol.15 No.5
In this paper a close solution is presented to determine the trade-off between cost and safety to cope with station blackout (SBO) in Pressurized Water Reactors (PWRs). To compute the profi t of each generation unit, a Supply Function Equilibrium (SFE) model swhich considers carbon tax is used in a uniform electricity market. A hierarchical heuristic method is applied for decision making on safety improvement of Nuclear Power Plants (NPPs). In this method the break-even point is used as a criterion to make a decision on comparing cost of safety improvement and profi t of NPP in a deregulated electricity market. This method is applied in a case of adding an Emergency Water Supply (EWS) and an Emergency Diesel Generator (EDG) to a NPP where impacts of its investment cost and its profi t are investigated. The achieved results show that the break-even point of investment cost and net profi t of the NPP by adding the EDG is one month later than NPP with addition of EWS.
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Masoud Rahimi,Elham Mohamadian,Soheil Dadari,Mohammad Moein Arbab,Naser Karimi 한국화학공학회 2017 Korean Journal of Chemical Engineering Vol.34 No.4
Microalgae are considered the biological drug factories of the future. To benefit from these microfactories, the intracellular metabolite of algae should be extracted. One of the most economically competitive methods is the ultrasound technique. This study was concerned with ultrasound-assisted extractions of useful substances from microalgae by comparing direct and indirect irradiation methods with respect to the extraction rate and yields. It is most likely that the direct and indirect irradiations had different irradiation powers. The systems were exposed to ultrasound wave (1.7 MHz) for 240min. For each system, the changes of optical density, concentration and biovolume of Chlorella were estimated. In addition, the concentration of extracted chlorophylls (a, b and a+b), carotenoid and lipid were measured. The factors were studied after 30, 60, 120, 180 and 240 min of exposure to ultrasound irradiation. Both direct and indirect irradiation systems produced cavitation in the cell membrane, and they reduced the concentration and biovolume of the Chlorella cells. The amount of lipids and chlorophylls was greater in the direct irradiation as compared to the indirect one, and it caused more cell disruption. However, the extraction of the carotenoid was less effective because direct irradiation produced more transmitted power of ultrasound, resulting in degradation of carotenoid. The results and analysis presented in this research showed that selection of the best method of irradiation is an important step, and it depends on the biomaterials to be extracted.
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