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Small RNAs: Classification, Biogenesis, and Function
V. Narry Kim 한국분자세포생물학회 2005 Molecules and cells Vol.19 No.1
Eukaryotes produce various types of small RNAs of 19-28 nt in length. With rapidly increasing numbers of small RNAs listed in recent years, we have come to realize how widespread their functions are and how diverse the biogenesis pathways have evolved. At the same time, we are beginning to grasp the common fea-tures and rules governing the key steps in small RNA pathways. In this review, I will summarize the current classification, biogenesis, action mechanism and func-tion of these fascinating molecules.
Biogenesis of small RNAs in animals
Kim, V. Narry,Han, Jinju,Siomi, Mikiko C. Nature Publishing Group 2009 NATURE REVIEWS MOLECULAR CELL BIOLOGY Vol.10 No.2
Small RNAs of 20–30 nucleotides can target both chromatin and transcripts, and thereby keep both the genome and the transcriptome under extensive surveillance. Recent progress in high-throughput sequencing has uncovered an astounding landscape of small RNAs in eukaryotic cells. Various small RNAs of distinctive characteristics have been found and can be classified into three classes based on their biogenesis mechanism and the type of Argonaute protein that they are associated with: microRNAs (miRNAs), endogenous small interfering RNAs (endo-siRNAs or esiRNAs) and Piwi-interacting RNAs (piRNAs). This Review summarizes our current knowledge of how these intriguing molecules are generated in animal cells.