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Biosafety and Toxicological Evaluation of Tissue-Cultured Echinacea purpurea Adventitious Roots
Murthy, Hosakatte Niranjana,Park, So-Young,Lee, Eun Jeong,Paek, Kee Yoeup Korean Society of Horticultural Science 2015 원예과학기술지 Vol.33 No.1
Echinacea purpurea (L.) Moench (purple cone flower) is an important medicinal plant; it can enhance immunity, relieve pain, and reduce inflammation, and also has hormonal, antiviral, and antioxidant effects. Adventitious root biomass of Echinacea purpurea was produced in commercial-scale bioreactors for use as a dietary supplement in the food industry and in traditional medicine. Biosafety and toxicological evaluations of tissue-cultured Echinacea purpurea adventitious roots (TCEPARs) were performed. Reverse mutation and chromosomal aberration tests showed no significant mutagenicity. Furthermore, repeated four-week oral dose tests performed in Sprague-Dawley rats did not show any notable changes in the general behavior of the rats, in the gross appearance of their internal organs, or in their mortality rate. There were no differences between the control group and the treatment group in parameters such as absolute body weight, hematology, blood chemistry, and absolute and relative organ weights. These findings indicate that TCEPARs are safe and nontoxic when consumed at an average dietary level and can be used as raw material for traditional medicine and the food industry.
Numerical simulation of an external prestressing technique for prestressed concrete end block
Murthy, A. Rama Chandra,Ganapathi, S. Chitra,Saibabu, S.,Lakshmanan, N.,Jayaraman, R.,Senthil, R. Techno-Press 2009 Structural Engineering and Mechanics, An Int'l Jou Vol.33 No.5
This paper presents the details of finite element (FE) modeling and analysis of an external prestressing technique to strengthen a prestressed concrete (PSC) end block. Various methods of external prestressing techniques have been discussed. In the proposed technique, transfer of external force is in shear mode on the end block creating a complex stress distribution. The proposed technique is useful when the ends of the PSC girders are not accessible. Finite element modeling issues have been outlined. Brief description about material nonlinearity including key aspects in modeling inelastic behaviour has been provided. Finite element (FE) modeling including material, loading has been explained in depth. FE analysis for linear and nonlinear static analysis has been conducted for varying external loadings. Various responses such as out-of-plane deformation and slip have been computed and compared with the corresponding experimental observations. From the study, it has been observed that the computed slope and slip of the steel bracket under external loading is in good agreement with the corresponding experimental observations.
Synthetic Approaches for the Nanoencapsulation of Fullerenes
Murthy, C. N.,Geckeler, K. E. WILEY-VCH Verlag 2006 Chem Inform Vol.37 No.41
<P>ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.</P>
Murthy, Indu K.,Bhat, Savithri,Sathyanarayan, Vani,Patgar, Sridhar,M., Beerappa,Bhat, P.R.,Bhat, D.M.,Gopalakrishnan, Ranjith,Jayaraman, Mathangi,Munsi, Madhushree,N.H., Ravindranath,M.A., Khalid,M., Institute of Forest Science 2014 Journal of Forest Science Vol.30 No.2
The tropical wet evergreen, tropical semi evergreen and moist deciduous forest types are projected to be impacted by climate change. In the Western Ghats region, a biodiversity hotspot, evergreen forests including semi evergreen account for 30% of the forest area and according to climate change impact model projections, nearly a third of these forest types are likely to undergo vegetation type change. Similarly, tropical moist deciduous forests which account for about 28% of the forest area are likely to experience change in about 20% of the area. Thus climate change could adversely impact forest biodiversity and product flow to the forest dependent households and communities in Uttara Kannada district of the Western Ghats. This study analyses the distribution of non-timber forest product yielding tree species through a network of twelve 1-ha permanent plots established in the district. Further, the extent of dependence of communities on forests is ascertained through questionnaire surveys. On an average 21% and 28% of the tree species in evergreen and deciduous forest types, respectively are, non-timber forest product yielding tree species, indicating potential high levels of supply of products to communities. Community dependence on non-timber forest products is significant, and it contributes to Rs. 1199 and Rs. 3561/household in the evergreen and deciduous zones, respectively. Given that the bulk of the forest grids in Uttara Kannada district are projected to undergo change, bulk of the species which provide multiple forest products are projected to experience die back and even mortality. Incorporation of climate change projections and impacts in forest planning and management is necessary to enable forest ecosystems to enhance resilience.
Murthy, A. Rama Chandra,Palani, G.S.,Iyer, Nagesh R. Techno-Press 2009 Structural Engineering and Mechanics, An Int'l Jou Vol.32 No.3
This paper presents analytical methodologies for remaining life prediction of plain concrete structural components considering tension softening and size effects. Non-linear fracture mechanics principles (NLFM) have been used for crack growth analysis and remaining life prediction. Various tension softening models such as linear, bi-linear, tri-linear, exponential and power curve have been presented with appropriate expressions. Size effect has been accounted for by modifying the Paris law, leading to a size adjusted Paris law, which gives crack length increment per cycle as a power function of the amplitude of a size adjusted stress intensity factor (SIF). Details of tension softening effects and size effect in the computation of SIF and remaining life prediction have been presented. Numerical studies have been conducted on three point bending concrete beams under constant amplitude loading. The predicted remaining life values with the combination of tension softening & size effects are in close agreement with the corresponding experimental values available in the literature for all the tension softening models.
Barriers to Realization of Forestry Mitigation Potential in India
Murthy, Indu K,Prasad KV, Devi Institute of Forest Science 2018 Journal of Forest Science Vol.34 No.5
Implementation of mitigation options on land is important for realisation of the goals of the Paris Agreement to stabilize temperature at $2^{\circ}C$. In India, the Intended Nationally Determined Contribution (INDC) targets include a forestry goal of creation of carbon sinks of 2.5 to 3 billion tonnes by 2030. There are however, multiple barriers to implementation of forestry mitigation options in India. They include environmental, social, financial, technological and institutional barriers. The barriers are varied not just across land categories but also for a land category depending on its regional location and distribution. In addition to these barriers is the impeding climate change that places at risk realisation of the mitigation potential as rising temperatures, drought, and fires associated with projected climate change may lead to forests becoming a weaker sink or a net carbon source before the end of the century.
The Relationships between CO<sub>2</sub> Emissions, Economic Growth and Life Expectancy
MURTHY, Uma,SHAARI, Mohd Shahidan,MARIADAS, Paul Anthony,ABIDIN, Noorazeela Zainol Korea Distribution Science Association 2021 The Journal of Asian Finance, Economics and Busine Vol.8 No.2
The issue of the relationship between environmental degradation and human health has been widely addressed by medical doctors. However, economists have sparsely debated it. The release of carbon dioxide (CO2) into the air can cause several environmental problems and, thus, it can affect human health. Therefore, it is imperative to examine the effect of CO2 emissions on life expectancy in the D-8 countries (Malaysia, Indonesia, Bangladesh, Nigeria, Egypt, Iran, Pakistan, and Turkey) from 1992 to 2017. The panel ARDL method is employed and, then, the PMG estimator is selected. The results show that economic growth, population growth and health expenditure can significantly and positively affect life expectancy, but CO2 emissions can have a significant and negative effect on life expectancy. Since, the major findings reveal that life expectancy can be explained by CO2 emissions. Hence, it is important to formulate policies on reducing CO2 emissions so that life expectancy will not be affected. Energy diversification policies should be formulated or improved in some countries. This is to ensure that the countries are not highly dependent on non-renewable energy that can harm the environment. The government should increase its expenditure on the health sector to save more lives by extend human lifespan.
Effect of steel fibres and nano silica on fracture properties of medium strength concrete
Murthy, A. Ramachandra,Ganesh, P. Techno-Press 2019 Advances in concrete construction Vol.7 No.3
This study presents the fracture properties of nano modified medium strength concrete (MSC). The nano particle used in this study is nano silica which replaces cement about 1 and 2% by weight, and the micro steel fibers are added about 0.4% volume of concrete. In addition to fracture properties, mechanical properties, namely, compressive strength, split tensile strength, and flexural strength of nano modified MSC are studied. To ensure the durability of the MSC, durability studies such as rapid chloride penetration test, sorptivity test, and water absorption test have been carried out for the nano modified MSC. From the study, it is observed that significant performance improvement in nano modified MSC in terms of strength and durability which could be attributed due to the addition pozzolanic reaction and the filler effect of nano silica. The incorporation of nano silica increases the fracture energy about 30% for mix without nano silica. Also, size independent fracture energy is arrived using two popular methods, namely, RILEM work of fracture method with $P-{\delta}$ tail correction and boundary effect method. Both the methods resulted in nearly the same size-independent $G_F$ irrespective of the notch to depth ratio of the same specimen. This shows evidence that either of the two procedures could be used in practice for analysis of cracked concrete structures.