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Mukesh Kumar 한국물리학회 2012 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.60 No.9
The induced current (fraction of the wall current) flowing through a strip is a very crucial quantity in stripline-type pick-ups and kickers. Quantities like the output voltage, coupling impedance and kicker constant depend on the fraction of the wall current flowing through the strip. Due to the fringe field at the side edges of the strip the effective angular width of the strip and, hence, the fraction of the wall current intercepted by the strip is enhanced. This paper presents a calculation, by using CST EM studio, of the fraction of the wall current intercepted by the strip. A correction factor for the effect of the fringe field on the current induced in the strip is also presented. The results obtained through simulations and through a new expression are compared with earlier existing expressions.
Design and Investigation of the DM- PC-TFET-Based Biosensor for Breast Cancer Cell Detection
Mukesh Kumar Bind,Sajai Vir Singh,Kaushal Kumar Nigam 한국전기전자재료학회 2023 Transactions on Electrical and Electronic Material Vol.24 No.5
In this paper, a dielectric modulated polarity control tunnel field-effect transistor (DM-PC-TFET)- based biosensor has been proposed for the first time for breast cancer cells (BCCs) detection. The detection method is based on the signifi cant difference in dielectric constant between cancerous and healthy breast cell lines in the microwave frequency band.When BCCs with different dielectric constants are filled in the sensing region of the proposed DM-PC-TFET-based biosensor, the electrical characteristics of the device vary, allowing for early-stage breast cancer detection. The sensing ability of the proposed biosensor has been investigated in terms of variation in drain current, threshold voltage, subthreshold swing, ON/ OFF current ratio, and transconductance characteristics. The proposed bio-sensor demonstrates drain current sensitivity of 7.82 × 1010 , I ON /I OFF ratio sensitivity of 2 .01 × 109 , and trans-conductance sensitivity of 2.32 × 1012 for T47D (a breast cancer cell line). Additionally, the proposed biosensor’s selectivity, linearity, and noise characteristics are evaluated in this study too. Furthermore, the sensitivity of the DM-PC-TFET biosensor has also been investigated with variations in BCCs charge density, temperature, device geometry, and non-uniform arrangement of cancer cell lines within the nano-cavity region. The simulation results of the proposed biosensor are generated using a 2D technology computer-aided design tool. The results demonstrate that the proposed biosensor can be used as a suitable and effi cient nano-device for the early detection of breast cancer.
Orthosiphon pallidus, a Potential Treatment for Patients with Breast Cancer
Mukesh K. Singh,Hemant Dhongade,Dulal Krishna Tripathi 대한약침학회 2017 Journal of pharmacopuncture Vol.20 No.4
Objective: Orthosiphon pallidus (O. pallidus), which belongs to the Lamiaceae family, is a popular garden plant that is widely used for the treatment of various diseases, such as urinary lithiasis, fever, hepatitis, cancer and jaundice. The objective of the present work was to investigate the antioxidant free-radical scavenging and the anticancer activities of O. pallidus against human breast-cancer cell lines. Methods: The antioxidant activity of Orthosiphon pallidus aqueous extract (OPAE) was investigated using different models, such as the 1,1-diphenyl-2-picrylhydrazyl (DPPH) and the 2, 2’-azinobis-(3-ethylbenzothiazoline- 6-sulfonic acid) (ABTS) models, as were the Fe+ chelation, the hydroxyl radical and superoxide radical scavenging, and total reducing power activities. The anticancer activities of the extract were determined by using the 3-(4, 5- dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide (MTT) and the sulforhodamine (SRB) assays on the MCF-7 and the MDA-MB-231 cancer cell lines. Results: The aqueous Orthosiphon pallidus extract showed potent activity in in-vitro models. It significantly inhibited the scavenging of hydroxyl and superoxide radicals, but induced a remarkable Fe+ chelation activity. For both cell lines, the percent cytotoxicity was found to increase steadily with increasing OPAE concentration up to 240 μg/mL. Conclusion: These results suggest that Orthosiphon pallidus has excellent antioxidant, antimicrobial, and anticancer activities against human breast-cancer cell lines.
Mukesh Kumar Yadav,Kallol Das,류정주,Seong-Keun Lim,Jin-Sil Choi,Lee Seung-Yeol,Hee-Young Jung 한국균학회 2023 韓國菌學會誌 Vol.51 No.2
A fungal strain designated KNUF-21-66Q1 was isolated from soil in Chungcheongbuk Province, Korea. Moderate growth of colonies was observed on potato dextrose agar, oatmeal agar (OA), malt extract agar, and cornmeal agar media at 25℃, and the detailed morphology was examined on OA medium. The colonies on OA medium were flat, had entire margin, hyaline, and yellow concentric rings in 3-4 weeks. Conidiomata were pycnidial, solitary or clustered, globose to subglobose, black-brown, and 300-500 μm in diameter. Conidiogenous cells were smooth, hyaline, globose to ampulliform, and 6.0- 9.0×3.0-6.0 μm in size (n=15). Conidia were hyaline to pale brown, slightly golden, obovoid to slightly ellipsoidal, smooth, guttulate, and 3.0-4.7×2.1-3.3 μm in size (n=100). The strain was confirmed based on phylogenetic analysis using internal transcribed spacer regions, the partial 28S rDNA of large subunit, and β-tubulin gene sequences. The morphological observations and phylogenetic analysis revealed that the strain KNUF-21-66Q1 was similar to the previously described Paraconiothyrium kelleni. To our knowledge, this is the first report of P. kelleni in Korea.
Biological and Medicinal Properties of Grapes and Their Bioactive Constituents: An Update
Mukesh Yadav,Shalini Jain,Aarti Bhardwaj,Ravinder Nagpal,Monica Puniya,Radha Tomar,Vinod Singh,Om Parkash,G.B.K.S. Prasad,Francesco Marotta,Hariom Yadav 한국식품영양과학회 2009 Journal of medicinal food Vol.12 No.3
The grape is one of the most valued conventional fruits, worldwide. Although most of the parts of the grapevine are useful, primarily, the grape is considered as a source of unique natural products not only for the development of valuable medicines against a number of diseases, but also for manufacturing various industrial products. Over the last few decades, apart from the chemistry of grape compounds, considerable progress has been made towards exploring the biological activities of various grape-derived constituents. Today, it is well established that in addition to serving as food, the grape is a major source of several phytochemicals. The main biologically active and well-characterized constituent from the grape is resveratrol, which is known for various medicinal properties in human diseases. This review discusses the roles of various grape-derived phytochemicals in relation to various diseases.