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Muhammad Rafiq,Muhammad Saleem,Muhammad Hanif,Muhammad Rizwan Maqsood,Nasim Hasan Rama,Ki-Hwan Lee,서승염 대한화학회 2012 Bulletin of the Korean Chemical Society Vol.33 No.12
A series of aromatic hydrazides 3a-j were prepared by refluxing esters 2a-j with hydrazine hydrate in methanol, which were prepared by the esterification of 1a-j. Acetohydrazides 3a-j upon treatment with carbon disulfide and methanolic potassium hydroxide yielded potassium dithiocarbazate salts 4a-j, which on refluxing with hydrazine hydrate yielded substituted 4-amino-5-aryl-3H-1,2,4-triazole-3-thiones 5a-j. The target compounds 6a-j were synthesized by condensing furan-3-carboxylic acid in the presence of polyphosphoric acid under reflux. The structures of newly synthesized compounds were characterized by IR, 1H NMR, 13C NMR, elemental analysis and mass spectrometric studies. All the synthesized compounds were screened for their urease, acetylcholine esterase inhibition, antioxidant and alkaline phosphatase inhibition activity. Almost all of the compounds 6a-j showed good to excellent activities against urease and acetylcholine esterase more than the reference drugs. Compounds 6f and 6g were more potent scavenger of free radicals than the reference n-propyl gallate. Compound 6b and 6h showed excellent activities of alkaline phosphatase as compare to the reference KH2PO4.
Muhammad Rizwan Maqsood,Muhammad Hanif,Muhammad Rafiq,Muhammad Saleem,Sumera Zaib,Aftab Ahmed Khan,Mazhar Iqbal,Jamshed Iqbal,Nasim Hasan Rama,서승염,Ki-Hwan Lee 대한화학회 2012 Bulletin of the Korean Chemical Society Vol.33 No.12
The target compounds 6-11a-e were synthesized by condensing 4-amino-5-aryl-3H-1,2,4-triazole-3-thiones 5a-f with various aromatic carboxylic acids in the presence of phosphorous oxychloride. The structures of newly synthesized compounds were characterized by IR, 1H NMR, 13C NMR, elemental analysis and mass spectrometric studies. All the synthesized compounds were screened for their antibacterial activity. Almost all the tested compounds were potent against four different strains of bacteria when compared with that of reference drug ciprofloxacin. Compounds 6c, 6e, 8d, 9b, 9e, 11a and 11b showed nearly equal or lower MIC values than standard drug, against all four tested bacterial strains but rest of the compounds showed excellent antibacterial activities.
Maqsood, Muhammad Rizwan,Hanif, Muhammad,Rafiq, Muhammad,Saleem, Muhammad,Zaib, Sumera,Khan, Aftab Ahmed,Iqbal, Mazhar,Iqbal, Jamshed,Rama, Nasim Hasan,Seo, Sung-Yum,Lee, Ki-Hwan Korean Chemical Society 2012 Bulletin of the Korean Chemical Society Vol.33 No.12
The target compounds 6-11a-e were synthesized by condensing 4-amino-5-aryl-3H-1,2,4-triazole-3-thiones 5a-f with various aromatic carboxylic acids in the presence of phosphorous oxychloride. The structures of newly synthesized compounds were characterized by IR, $^1H$ NMR, $^{13}C$ NMR, elemental analysis and mass spectrometric studies. All the synthesized compounds were screened for their antibacterial activity. Almost all the tested compounds were potent against four different strains of bacteria when compared with that of reference drug ciprofloxacin. Compounds 6c, 6e, 8d, 9b, 9e, 11a and 11b showed nearly equal or lower MIC values than standard drug, against all four tested bacterial strains but rest of the compounds showed excellent antibacterial activities.
Rafiq, Muhammad,Saleem, Muhammad,Hanif, Muhammad,Maqsood, Muhammad Rizwan,Rama, Nasim Hasan,Lee, Ki-Hwan,Seo, Sung-Yum Korean Chemical Society 2012 Bulletin of the Korean Chemical Society Vol.33 No.12
A series of aromatic hydrazides 3a-j were prepared by refluxing esters 2a-j with hydrazine hydrate in methanol, which were prepared by the esterification of 1a-j. Acetohydrazides 3a-j upon treatment with carbon disulfide and methanolic potassium hydroxide yielded potassium dithiocarbazate salts 4a-j, which on refluxing with hydrazine hydrate yielded substituted 4-amino-5-aryl-3H-1,2,4-triazole-3-thiones 5a-j. The target compounds 6a-j were synthesized by condensing furan-3-carboxylic acid in the presence of polyphosphoric acid under reflux. The structures of newly synthesized compounds were characterized by IR, $^1H$ NMR, $^{13}C$ NMR, elemental analysis and mass spectrometric studies. All the synthesized compounds were screened for their urease, acetylcholine esterase inhibition, antioxidant and alkaline phosphatase inhibition activity. Almost all of the compounds 6a-j showed good to excellent activities against urease and acetylcholine esterase more than the reference drugs. Compounds 6f and 6g were more potent scavenger of free radicals than the reference n-propyl gallate. Compound 6b and 6h showed excellent activities of alkaline phosphatase as compare to the reference $KH_2PO_4$.
Qayyum, Muhammad Farooq,Rehman, Muhammad Zia ur,Ali, Shafaqat,Rizwan, Muhammad,Naeem, Asif,Maqsood, Muhammad Aamer,Khalid, Hinnan,Rinklebe, Jö,rg,Ok, Yong Sik Elsevier 2017 CHEMOSPHERE - Vol.174 No.-
<P><B>Abstract</B></P> <P>Cadmium (Cd) accumulation in agricultural soils is one of the major threats to food security. The application of inorganic amendments such as mono-ammonium phosphate (MAP), gypsum and elemental sulfur (S) could alleviate the negative effects of Cd in crops. However, their long-term residual effects on decreasing Cd uptake in latter crops remain unclear. A field that had previously been applied with treatments including control and 0.2, 0.4 and 0.8% by weight of each MAP, gypsum and S, and grown with wheat and rice and thereafter wheat in the rotation was selected for this study. Wheat (<I>Triticum aestivum</I> L.) was grown in the same field as the third crop without further application of amendments to evaluate the residual effects of the amendments on Cd uptake by wheat. Plants were harvested at maturity and grain, and straw yield along with Cd concentration in soil, straw, and grains was determined. The addition of MAP and gypsum significantly increased wheat growth and yield and decreased Cd accumulation in straw and grains compared to control while the reverse was found in S application. Both MAP and gypsum decreased AB-DTPA extractable Cd in soil while S increased the bioavailable Cd in soil. Both MAP and gypsum increased the Cd immobilization in the soil and S decreased Cd immobilization in a dose-additive manner. We conclude that MAP and gypsum had a significant residual effect on decreasing Cd uptake in wheat. The cost-benefit ratio revealed that gypsum is an effective amendment for decreasing Cd concentration in plants.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Residual monoammonium phosphate (MAP) and gypsum reduced the Cd uptake in wheat. </LI> <LI> Amendment of residual elemental sulfur (S) increased Cd uptake in plants. </LI> <LI> Gypsum had the highest cost-benefit ratio compared with MAP and elemental S. </LI> <LI> Gypsum may be used to enhance crop production in Cd-contaminated soils. </LI> </UL> </P>
Muhammad Maqsood,Rahmatullah Qureshi,Masroor Ikram,M. Sheeraz Ahmad,Bushra Jabeen,Muhammad Rafique Asi,Junaid Ahmed Khan,Safdar Ali,Lothar Lilge 한국한의학연구원 2018 Integrative Medicine Research Vol.7 No.2
Background: The Pakistani Salt Range has a rich floral diversity including Withania coagulans from the Solanaceae family. Methods: The crude methanolic extracts of the root, leaf, leaf stalk, and fruit of this plant were screened for their cytotoxic activity against human (HeLa, MCF-7, RD) and rat (RG2 and INS-1) cancer cell lines at 20 μg/mL and compared to methotrexate. The IC50 values indicated that leaf stalk and fruit extracts exert an 80% or higher cytotoxic activity against all cell lines at 24 hours. Results: The leaf stalk extract showed the highest cytotoxic efficacy against all tested cell lines, with IC50 values ranging from 0.96 ± 0.01 μg/mL to 4.73 ± 0.05 μg/mL followed by the fruit extract with IC50 values of 0.69 ± 0.01–6.69 ± 0.06 μg/mL after 48–72 hours incubation. The leaf stalk and seed extracts were analyzed for polyphenols and flavonoids using RP-HPLC. The total flavonoid content (TFC) was calculated for all tested samples, and the highest TFC was recorded for the root extract (394.34 ± 1.26 μg/g). The total phenolic content (TPC) was found in the seed extract (307.86 ± 9.42 μg/g) of W. coagulans. The highest contents of myricetin (358.46 ± 2.91 μg/g) were noted in the leaf extract, and highest quercetin was recorded in the seed extract (21.43 ± 0.13 μg/g). The highest gallic acid concentration (83.62 ± 0.71 μg/g) was recorded in leaf stalk extract and p-hydroxybenzoic acid in the seed extract (157.46 ± 1.43 μg/g). Conclusion: The present study gives a scientific insight and comparative analysis of various plant parts in this medicinally important plant species from the Salt Range of Pakistan against both human and rat cancer cells.
Muhammad Maqsood,Gunnar Seide 한국섬유공학회 2018 Fibers and polymers Vol.19 No.5
Polylactic acid (PLA) is a biodegradable and compostable polymer obtained from annually renewable resources and is acknowledged to be sustainable and non-polluting polymer with substantial commercial prospective as a textile fiber however, there is lack of literature on apparel applications of this polymer. Therefore in this study it was aimed to develop biobased compostable gloves from PLA draw textured melt spun yarns and to examine the effect of yarn linear density, fabric structure and stitch density on thermo-physiological comfort and moisture management properties of PLA based gloves. 100 % PLA based multifilament yarns of two different linear densities were melt spun and later draw textured on false twist texturing machine to be used for gloves knitting. Single jersey and rib structures were produced with two different stitch densities to investigate their effect on thermal conductivity, thermal resistance, relative water vapour permeability, air permeability and moisture management properties of the gloves. Minitab statistical software was employed to analyze the results of test samples. The coefficients of determinations (R2 values) presented good estimation capability of the established regression models. The outcomes of this research may be useful in determining suitable manufacturing requirements of PLA based gloves to accomplish precise thermo-physiological and moisture management properties.
Ensemble-classifiers-assisted detection of cerebral microbleeds in brain MRI
Ateeq, Tayyab,Majeed, Muhammad Nadeem,Anwar, Syed Muhammad,Maqsood, Muazzam,Rehman, Zahoor-ur,Lee, Jong Weon,Muhammad, Khan,Wang, Shuihua,Baik, Sung Wook,Mehmood, Irfan Elsevier 2018 Computers & electrical engineering Vol.69 No.-
<P>Cerebral Microbleeds (CMBs) are considered as an essential indicator in the diagnosis of critical cerebrovascular diseases such as ischemic stroke and dementia. Manual detection of CMBs is prone to errors due to complex morphological nature of CMBs. In this paper, an efficient method is presented for CMB detection in Susceptibility-Weighted Imaging (SWI) scans. The proposed framework consists of three phases: i) brain extraction, ii) extraction of initial candidates based on threshold and size based filtering, and iii) feature extraction and classification of CMBs from other healthy tissues in order to remove false positives using Support Vector Machine, Quadratic Discriminant Analysis (QDA) and ensemble classifiers. The proposed technique is validated on a dataset of 20 subjects with CMBs that consists of 14 subjects for training and 6 subjects for testing. QDA classifier achieved the best sensitivity of 93.7% with 56 false positives per patient and 5.3 false positives per CMB. (C) 2018 Elsevier Ltd. All rights reserved.</P>
An Efficient Optimization Technique for Node Clustering in VANETs Using Gray Wolf Optimization
( Muhammad Fahad Khan ),( Farhan Aadil ),( Muazzam Maqsood ),( Salabat Khan ),( Bilal Haider Bukhari ) 한국인터넷정보학회 2018 KSII Transactions on Internet and Information Syst Vol.12 No.9
Many methods have been developed for the vehicles to create clusters in vehicular ad hoc networks (VANETs). Usually, nodes are vehicles in the VANETs, and they are dynamic in nature. Clusters of vehicles are made for making the communication between the network nodes. Cluster Heads (CHs) are selected in each cluster for managing the whole cluster. This CH maintains the communication in the same cluster and with outside the other cluster. The lifetime of the cluster should be longer for increasing the performance of the network. Meanwhile, lesser the CH's in the network also lead to efficient communication in the VANETs. In this paper, a novel algorithm for clustering which is based on the social behavior of Gray Wolf Optimization (GWO) for VANET named as Intelligent Clustering using Gray Wolf Optimization (ICGWO) is proposed. This clustering based algorithm provides the optimized solution for smooth and robust communication in the VANETs. The key parameters of proposed algorithm are grid size, load balance factor (LBF), the speed of the nodes, directions and transmission range. The ICGWO is compared with the well-known meta-heuristics, Multi-Objective Particle Swarm Optimization (MOPSO) and Comprehensive Learning Particle Swarm Optimization (CLPSO) for clustering in VANETs. Experiments are performed by varying the key parameters of the ICGWO, for measuring the effectiveness of the proposed algorithm. These parameters include grid sizes, transmission ranges, and a number of nodes. The effectiveness of the proposed algorithm is evaluated in terms of optimization of number of cluster with respect to transmission range, grid size and number of nodes. ICGWO selects the 10% of the nodes as CHs where as CLPSO and MOPSO selects the 13% and 14% respectively.