Is there a characteristic pattern of ambulatory blood pressure profile in type 1 diabetic children and adolescents?

Morić Bernardica Valent,Šamija Ivan,Sabolić Lavinia La Grasta,Stipančić Gordana 대한소아내분비학회 2022 Apem Vol.27 No.4

Purpose: To examine the characteristics of ambulatory blood pressure (ABP) including blood pressure variability (BPV) and its association with albuminuria in type 1 diabetic (T1D) children and to identify potential predictors of high-normal albuminuria and microalbuminuria.Methods: ABP monitoring was performed in 201 T1D children and adolescents (mean age, 14.7±3.8 years) with T1D duration over 1 year. The level of albuminuria was assessed as the albumin/creatinine ratio (ACR) and patients were further classified as low-normal, high-normal or microalbuminuria.Results: Fifteen T1D children (7.5%) were hypertensive using office blood pressure (BP) and 10 (5%) according to ABP. T1D subjects had elevated 24-hour systolic BP (SBP) and diastolic BP (DBP) (+0.2 and + 0.3 standard deviation score [SDS]) and nighttime SBP and DBP (+0.6 and +0.8 SDS) compared to reference values. Patients with microalbuminuria had significantly higher 24-hour, daytime and nighttime DBP compared to normoalbuminuric subjects. There was a high percentage of nondippers (74.1%). Nighttime diastolic BPV was significantly higher in subjects with high-normal compared to low-normal albuminuria (<i>p</i>=0.01). A weak correlation was found between ACR and daytime DBP SDS (<i>r</i>=0.29, <i>p</i><0.001 and nighttime DBP SDS (<i>r</i>=0.21, <i>p</i>=0.003). Age and nighttime diastolic BPV were predictors of high-normal albuminuria while nighttime DBP was a strong predictor for microalbuminuria.Conclusion: T1D children have impaired BP regulation although most of them do not fulfill the criteria for sustained hypertension. There is an association between diastolic ABP and diastolic BPV with rising levels of albuminuria pointing to a clear connection between BP and incipient diabetic nephropathy.

Is there a characteristic pattern of ambulatory blood pressure profile in type 1 diabetic children and adolescents?

Morić Bernardica Valent,Šamija Ivan,Sabolić Lavinia La Grasta,Stipančić Gordana 대한소아내분비학회 2022 Annals of Pediatirc Endocrinology & Metabolism Vol.27 No.4

Purpose: To examine the characteristics of ambulatory blood pressure (ABP) including blood pressure variability (BPV) and its association with albuminuria in type 1 diabetic (T1D) children and to identify potential predictors of high-normal albuminuria and microalbuminuria. Methods: ABP monitoring was performed in 201 T1D children and adolescents (mean age, 14.7±3.8 years) with T1D duration over 1 year. The level of albuminuria was assessed as the albumin/creatinine ratio (ACR) and patients were further classified as low-normal, high-normal or microalbuminuria. Results: Fifteen T1D children (7.5%) were hypertensive using office blood pressure (BP) and 10 (5%) according to ABP. T1D subjects had elevated 24-hour systolic BP (SBP) and diastolic BP (DBP) (+0.2 and + 0.3 standard deviation score [SDS]) and nighttime SBP and DBP (+0.6 and +0.8 SDS) compared to reference values. Patients with microalbuminuria had significantly higher 24-hour, daytime and nighttime DBP compared to normoalbuminuric subjects. There was a high percentage of nondippers (74.1%). Nighttime diastolic BPV was significantly higher in subjects with high-normal compared to low-normal albuminuria (P=0.01). A weak correlation was found between ACR and daytime DBP SDS (r=0.29, P<0.001 and nighttime DBP SDS (r=0.21, P=0.003). Age and nighttime diastolic BPV were predictors of high-normal albuminuria while nighttime DBP was a strong predictor for microalbuminuria. Conclusion: T1D children have impaired BP regulation although most of them do not fulfill the criteria for sustained hypertension. There is an association between diastolic ABP and diastolic BPV with rising levels of albuminuria pointing to a clear connection between BP and incipient diabetic nephropathy.

Low-cost and low-technology oriented improvement of visual environment at intersections by ergonomic installation of traffic convex mirrors for preventive safety against crossing collisions

Mori Mori,Sadao Horino,Yuji Inomata,Hiroki Sasayama,Yuko Hirota 대한인간공학회 2007 대한인간공학회 학술대회논문집 Vol.- No.-

In Japan, Quarter-million crossing collisions at intersections accounted for one-fourth of the total accidents in 2005. Three-fourths of collisions took place at urban intersections, more than half of them occurred at uncontrolled intersections. Risks of crossing collisions depend on the quality of visual environment at intersection. This study aimed to assess the legibility and effectiveness of 23 traffic convex mirrors installed at 10 urban intersections, after the road management authority inspected and repaired. The legibility of mirror was assessed by means of the photographs of each mirror taken from the drivers’ viewpoint at a legal stop line, entering from the lower priority direction. “Three ergonomics requirements” suggested by the authors were used as the criteria of legibility assessment; (1) Position of road lane, (2) Blind area and (3) Road surface markings. Combining these 3 criteria, the comprehensive assessment of mirror was indicated in 2-grade scale, such as “Good” or “Poor”, namely so dangerous to be improved. A field assessment revealed that 11 among 23 mirrors were still improperly installed. However, simulation analysis showed that 7 among 11 poor mirrors could be improved by adjusting the angle of mirror plate or displacing mirror plate/poles. In conclusion, the present official guideline in regard with installing mirror should be revised to add newly “three ergonomics requirements” for preventive safety. Application of these new guidelines in practice, a typical low-cost and low technology-oriented improvement to reduce crossing collisions, was highly recommended.

Insect-produced Elicitors, Fatty Acid Amino Acid Conjugates:Insights from Physiological Point of View

Naoki Mori,Naoko Yoshinaga 한국응용곤충학회 2013 한국응용곤충학회 학술대회논문집 Vol.2013 No.04

Fatty acid-amino acid conjugates (FACs), first identified from beet armyworm Spodoptera exigua larvae (Alborn et al., 1997), have been found in noctuid as well as sphingid caterpillar oral secretions and especially volicitin [N-(17-hydroxylinolenoyl)- L-glutamine, 17OH-volicitn] and its biochemical precursor, N-linolenoyl- L-glutamine, are known elicitors of induced volatile emissions in corn plants. We conducted FAC screening of 29 lepidopteran species and found FACs in 19 of these species (Yoshinaga & Mori et al., 2010). Thus, FACs are quite commonly synthesized through a broad range of lepidopteran caterpillars. From an evolutionary perspective, it is presumed that volicitin and the other FACs, although consequently unfavorable to the insect in the plant-herbivore interactions, are produced because they are essential part of the primary metabolism of the insects. In this context, we suggested that FACs in Spodoptera litura play an active role in nitrogen assimilation by regulating the amount of glutamine in the larval midgut (Yoshinaga & Mori et al., 2008). The benefits of the physiological function of FACs for the herbivores need to outweigh the costs caused by induction of plant defense

Crop improvement : Original Paper ; Expression of an enhancin gene from the Trichoplusia ni granulosis virus confers resistance to Lepidopterous insect pests to rice

( Mari Mori ),( Harushige Kitamura ),( Atsushi Kondo ),( Koji Dohi ),( Masashi Mori ),( Masanori Kaido ),( Kazuyuki Mise ),( Eiichi Shimojyo ),( Yoshifumi Hashimoto ) 한국식물생명공학회 ( 구 한국식물조직배양학회 ) 2006 Plant Biotechnology Vol.23 No.1

A synthesis method of gene networks based on gene expression by network learning

Yoshihiro Mori,Yasuaki Kuroe,Takehiro Mori 제어로봇시스템학회 2006 제어로봇시스템학회 국제학술대회 논문집 Vol.2006 No.10

Effect of a dynamic absorber on friction-induced vibration of a rectangular plate

Hiroki Mori,Oleksandr Mikhyeyev,Takuo Nagamine,Mizue Mori,Yuichi Sato 대한기계학회 2010 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.24 No.1

When a plate-like object is rubbed by rubber, friction-induced vibration is generated. To reduce the friction-induced vibration, we experimentally investigate the characteristics of the vibration of a rectangular glass plate. The results show that the frequency of the frictioninduced vibration is almost the same as the natural frequency of a glass plate. The vibration is generated when the natural frequency of a rubbing system is close to that of a glass plate. We then examine the effect of a dynamic absorber mounted on the glass plate. The results demonstrate that the damping of a dynamic absorber is effective for suppressing the friction-induced vibration. Numerical simulation is also performed using a simplified analytical model. The calculated results agree qualitatively with the experimental ones.

From the Sequence to Cell Modeling : Comprehensive Functional Genomics in Escherichia coli

Mori, Hirotada 한국생화학분자생물학회 2004 BMB Reports Vol.37 No.1

As a result of the enormous amount of information that has been collected with E. coli over the past half century (e.g. genome sequence, mutant phenotypes, metabolic and regulatory networks, etc.), we now have detailed knowledge about gene regulation, protein activity, several hundred enzyme reactions, metabolic pathways, macromolecular machines, and regulatory interactions for this model organism. However, understanding how all these processes interact to form a living cell will require further characterization, quantification, data integration, and mathematical modeling, systems biology. No organism can rival E. coli with respect to the amount of available basic information and experimental tractability for the technologies needed for this undertaking. A focused, systematic effort to understand the E. cofi cell will accelerate the development of new post-genomic technologies, including both experimental and computational tools. It will also lead to new technologies that will be applicable to other organisms, from microbes to plants, animals, and humans. E. coli is not only the best studied free-living model organism, but is also an extensively used microbe for industrial applications, especially for the production of small molecules of interest. It is an excellent representative of Gram-negative commensal bacteria. E. cofi may represent a perfect model organism for systems biology that is aimed at elucidating both its free-living and commensal life-styles, which should open the door to whole-cell modeling and simulation.

The Outbreak of the Sino-Japanese War and the Issue of Suzerain-Vassal as Viewed from the Standpoint of Chosŏn

Mori Mayuko(모리마유코) 고려대학교 한국사연구소 2012 International Journal of Korean History Vol.17 No.1

청일전쟁은 동아시아 근대사의 분수령이 된 사건이다. 청일전쟁 이전의 동아시아에는 청조를 중심으로 한 중화질서와 국제법을 기반으로 한 조약체제의 두 가지 질서가 공존했는데, 전쟁 이후에는 전자가 붕괴되고 후자로 일원화되었던 것이다. 따라서 청일전쟁의 결과 무너진 朝鮮과 淸朝의 宗屬關係가 개전 과정에서 어떻게 논의되었는지를 밝히는 것은 중요하다. 본고는 이 문제를 조선에 주목하여 분석한 논문이다. 여기서 조선이라 함은 지리적인 관점을 의미하여 구체적으로는 駐朝鮮 日本公使館과 조선정부에 초점을 맞추었다. 1885년의 天律條約에서는 표면적으로는 청과 일본의 평등성이 표명되었지만, 1885년 이후의 동아시아 정세에서 청조가 국제적인 지위를 높여갔던 반면에 일본의 지위는 상대적으로 낮아졌다. 청조는 이러한 국제관계를 배경으로 조선에 대한 간섭을 강화하였는데, 이에 대해 조선은 ‘屬國自主’의 ‘自主’를 바탕으로 대외정책을 전개하였다. 일본은 朝淸의 종속관계를 인정하지 않았지만 영국과의 불평등조약 개정을 우선하였기 때문에 종속문제를 거론함으로써 유발되는 청조와의 대립을 원하지 않았고, 따라서 조선독립에 대한 논의도 끝낼 수 없었다. 이에 1885년 이후의 동아시아 국제질서는 ‘屬國自主’가 括抗하는 朝淸關係와 天律條約에 의해 표면상 대등한 淸日關係, 그리고 독립론을 보류한 朝日關係가 뒤섞여 균형을 이룬 채 청일전쟁 전까지 유지되었다. 그러나 1894년에 김옥균 암살과 동학농민운동에 대한 청조의 출병이 이어지면서 일본정부는 점차 청일개전으로 기울어졌다. 다만 일본정부는 구미열강의 눈을 의식하여 개전 과정에서 종속문제를 거론하는 것을 기피하고, 대신에 조선내정개혁을 그 명분으로 삼았다. 한편 駐朝鮮 日本公使館은 조선의 독립을 명확하게 하기 위해 종속문제를 거론함으로써 개전으로 유도해가고자 하였다. 그러나 일본정부와 공사관은 통신망의 불통으로 이러한 입장 차이에 대해 충분히 상의할 수 없었다. 결국 공사관이 정부에서 부여된 재량권을 바탕으로 왕궁점거를 단행하여 청일 개전의 단서를 열었다. 다음으로 같은 시기의 조선정부의 대응을 살펴보았다. 청일전쟁의 원인은 조선정부가 동학농민운동에 대해 종속관계에 기탁하여 청조에 원병을 요청한 데에 있다. 청병의 출병으로 인해 天津조약에 따라 일본군도 조선에 출병하였고, 동학농민운동이 수습된 후에도 청일 양군은 그대로 조선에 주둔하였다. 이에 대해 조선정부는 일본군을 철병시키고자 종속관계에 의거하여 ‘平安道監司-駐津督理-天律海關道(-李鴻章)’라는 정보 전달 라인을 가동하고 청조의 원조를 이끌어내고자 하였다. 동시에 조선정부는 구미열강과 체결한 조약 중의 居中調整 조문을 활용하여 駐朝鮮 각국 대표에게 청일 양군의 철병을 조정해줄 것을 요청하였다. 조선정부의 이러한 시도는 청일 개전을 막는 데에 큰 영향을 미치지 못했다. 하지만 개전 직전에 조선정부가 종속관계와 조약체제의 두 가지 질서를 유지하고자 한 것은 조선의 대외정책을 외교의 근대화라는 근대성만으로는 이해할 수 없을 것임을 시사한다.

Vulnerability assessment of strategic buildings based on ambient vibrations measurements

Mori, Federico,Spina, Daniele Techno-Press 2015 Structural monitoring and maintenance Vol.2 No.2

This paper presents a new method for seismic vulnerability assessment of buildings with reference to their operational limit state. The importance of this kind of evaluation arises from the civil protection necessity that some buildings, considered strategic for seismic emergency management, should retain their functionality also after a destructive earthquake. The method is based on the identification of experimental modal parameters from ambient vibrations measurements. The knowledge of the experimental modes allows to perform a linear spectral analysis computing the maximum structural drifts of the building caused by an assigned earthquake. Operational condition is then evaluated by comparing the maximum building drifts with the reference value assigned by the Italian Technical Code for the operational limit state. The uncertainty about the actual building seismic frequencies, typically significantly lower than the ambient ones, is explicitly taken into account through a probabilistic approach that allows to define for the building the Operational Index together with the Operational Probability Curve. The method is validated with experimental seismic data from a permanently monitored public building: by comparing the probabilistic prediction and the building experimental drifts, resulting from three weak earthquakes, the reliability of the method is confirmed. Finally an application of the method to a strategic building in Italy is presented: all the procedure, from ambient vibrations measurement, to seismic input definition, up to the computation of the Operational Probability Curve is illustrated.