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Danielle Ooyoung Pyun,Miri K. Chung,Ho Jung Choi 고려대학교 언어정보연구소 2013 언어정보 Vol.17 No.-
Pyun, Danielle O., Chung, Miri K. & Choi, Ho Jung. 2013. KFL learners’ acquisition of Korean locative particles: A corpus-based contrastive interlanguage analysis. Language Information. Volume 17. 23-46. Adopting the contrastive interlanguage analysis methodology, this study investigates KFL (Korean as a Foreign Language) learners’ acquisition of Korean locative case particles. A learner corpus compiled from eighty-seven intermediate learners of Korean was compared with a native speaker corpus on the frequency distribution of the five semantic categories of the Korean locative case (i.e, static location, dynamic location, time, goal, and source). In addition, learner errors on the use of locative case particles were quantified and examined according to the five semantic categories. The results of this study showed that KFL learners’ use of locative case particles substantially deviated from native speakers’ usage in frequency. Learners’ inaccurate and limited use of locative case particles were attributed to such factors as L1 transfer, overgeneralization, prior input, and interlanguage development.
Willingness-to-pay of patients with chronic skin diseases
( Jung Min Bae ),( Ro Woo Lee ),( Hyun Jeong Ju ),( Ju Hee Han ),( Ju Hee Lee ),( Yu Ri Woo ),( Ji Hae Lee ),( Chul Hwan Bang ),( Miri Kim ),( Jung Eun Kim ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.2
Background: Chronic skin diseases have significant impacts on the quality of life (QoL) of the patients, although not life threatening. Recently, willingness-to-pay (WTP) questionnaire was developed to assess disease burden economically. Objectives: To evaluate WTP in patients with chronic skin diseases in Korea. Methods: We enrolled patients with 7 chronic skin diseases including atopic dermatitis (AD), psoriasis, vitiligo, alopecia areata (AA), chronic urticaria (CU), rosacea, and seborrheic dermatitis (SD). QoL was evaluated using the Dermatology Life Quality Index (DLQI) questionnaire, and WTP was assessed from two aspects: monthly WTP for disease control and one-time WTP for disease cure. Results: A total of 477 patients (216 males; mean age: 41.6 years) were enrolled (AD: 85, psoriasis: 58, vitiligo: 93, AA: 47, CU: 82, rosacea: 58, and SD: 54). While the median DLQI score was highest in AD patients (13), the median monthly WTP control and one-time WTP cure were highest in vitiligo ($134 and $1891 each). WTP did not show a positive correlation with BSA in vitiligo, unlike AD and psoriasis. Conclusion: We demonstrate that WTP was the highest in vitiligo, although it had a lower DLQI score than others. It may imply that DLQI is not a critical indicator of patient’s treatment decision. Furthermore, vitiligo patients with small BSA (<1%) also have high WTP comparable to those with large BSA, unlike AD and psoriasis.
정미리(Miri Jung),황영(Young Hwang),김혜영(Hae Young Kim),조명철(Myeong Cheoul Cho),황인국(In Guk Hwang),유선미(Seon Mi Yoo),정헌상(Heon-Sang Jeong),이준수(Junsoo Lee) 한국식품영양과학회 2011 한국식품영양과학회지 Vol.40 No.5
본 연구에서는 40여종의 육성계통 고추의 기능성 성분의 함량을 분석 및 활성 평가를 함으로써 우수 고추 품종 개발을 위한 database를 제공하고자 하였다. 연구 결과 capsaicinoid의 함량은 0.1에서 204.2 ㎎/100 g으로 나타났으며 ascorbic acid 함량은 279.1에서 1695.5 ㎎/100 g으로 넓은 분포 범위를 보였다. Polyphenol 함량은 2.6에서 10.2 ㎎/g 수준으로, flavonoid 함량은 1.4에서 5.7 ㎎/g 수준으로 나타났다. 항산화 활성 측정 결과는 육성계통 고추 breeding line No. 2500은 다른 계통에 비해 가장 높은 DPPH와 ABTS 라디칼 제거능을 나타내었으며 polyphenol과 flavonoid 함량 및 환원력이 다른 육성계통에 비해 높은 값을 나타내었다. 항암 효과는 breeding line No. 3201이 암세포 증식 저해율 84.5%로 가장 높은 효과를 나타내었으며 항염증 효과는 breeding line No. 3232가 75.2%로 가장 높은 nitric oxide 생성 억제율을 확인하였다. 본 연구에서는 육성계통에 따른 고추의 기능성 성분을 분석하고 다양한 생리활성을 평가하여 우수 품종 개량을 위한 성분 및 활성 database로 활용될 수 있을 것으로 생각된다. The purpose of this study was to determine the capsaicinoid and antioxidant compounds and to evaluate thebiological activity of 40 different pepper (Capsicum annuum L.) breeding lines. Capsaicinoid and ascorbic acidcontent were measured with HPLC. Total polyphenolic and flavonoid contents and antioxidant activity weremeasured with spectrophotometric methods. The antiproliferative qualities of the samples against human breasttumor cells (MCF7) were assessed with a MTT assay. The nitric oxide content in the culture media was measuredto evaluate the anti-inflammatory qualities of the samples using Raw264.7 macrophages. The capsaicinoid, ascorbicacid, polyphenolic and flavonoid content of the 40 pepper breeding lines were 0.1~204.2 ㎎/100 g (dryweight basis, DWB), 279.1~1695.5 ㎎/g (DWB), 2.6~10.2 ㎎/g (DWB), and 1.4~5.7 ㎎/g (DWB), respectively.The highest antioxidant, antiproliferative, and anti-inflammatory qualities were found in breeding line numbers2500, 3201, and 3232, respectively. This study provides basic information useful to plant breeders and biotechnologistswho are planning to breed pepper genotypes with high phytochemical content.
고추의 육성계통에 따른 Capsaicinoids와 Ascorbic Acid 분석
정미리(Miri Jung),황영(Young Hwang),김혜영(Hae Young Kim),정헌상(Heong-Sang Jeong),박지성(Jisung Park),박동복(Dongbok Park),이준수(Junsoo Lee) 한국식품영양과학회 2010 한국식품영양과학회지 Vol.39 No.11
본 연구에서는 130여종의 육성계통 고추의 capsaicinoids와 ascorbic acid 등의 기능성 성분의 함량을 분석함으로써 부가가치 높은 우수 고추 품종 개발을 위한 database를 제공하고자 하였다. Capsaicinoids 및 ascorbic acid 분석을 위해 역상 HPLC를 이용하였다. 연구 결과 capsaicin의 평균함량은 29.0 ㎎/100g, dihydrocapsaicin은 15.8 ㎎/100g으로 나타났으며 ascorbic acid의 평균 함량은 809.8 ㎎/100g이었다. 육성계통 고추 No.2687의 capsaicin 함량은 219.6㎎/100g, dihydrocapsaicin 함량은 110.8 ㎎/100g으로 가장 높게 분석되었으나 ascorbic acid 함량은 264.9 ㎎/100g으로 가장 낮게 분석되었다. 또한 육성계통 고추 No. 2524가 ascorbic acid의 함량이 1695.5 ㎎/100g으로 가장 높았으나 capsaicinoid 함량은 평균 이하로 낮게 나타났다. 분석방법을 검증하기 위해 재현성, 반복성 및 회수율을 구하였으며 그 결과 재현성과 반복성의 CV는 5% 이하였으며 회수율은 90% 이상으로 우수하였다. 본 연구 결과는 고추의 육성 계통별 기능성 성분의 함량을 분석하고 그 결과를 토대로 우수품종 개발을 위한 기초자료를 제공함에 그 의의가 있다. Peppers (Capsicum annuum L.) are a rich source of phytochemicals including polyphenolics, flavonoids, capsaicinoids and ascorbic acid. Capsaicinoids are a group of 12 or more related alkaloids responsible for the pungent sensation in the fruits of the genus Capsicum. Ascorbic acid is another functional and nutritional constituent of peppers. In this study, the contents of two major capsaicinoids (capsaicin and dihydrocapsaicin) and ascorbic acid in 131 pepper breeding lines were quantified by HPLC. In 131 pepper breeding lines, capsaicin and dihydrocapsaicin contents were in the range of 0.0 to 219.6 and 0.0 to 110.8 ㎎/100 g, respectively. The breeding lines with higher capsaicin content contained higher dihydrocapsaicin content as well. Ascorbic acid contents were 264.9 to 1695.5 ㎎/100 g for the 131 pepper breeding lines. The analytical method validation parameters including accuracy, repeatability, and reproducibility were calculated to ensure the method's validity. This study provides basic information to plant breeders and biotechnologists who are planning to breed genotypes with high content of phytochemicals.
( Miri Kim ),( Kyung Eun Kim ),( Haw Young Jung ),( Baik Kee Cho ),( Dae Ho Cho ),( Hyun Jeong Park ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2
Background: Rosacea is a chronic inflammatory skin disease characterized by erythema of the central face. Erythroid differentiation regulator 1 (Erdr1) is an anti-metastatic factor and negatively regulated by IL-18. IL-18 is a well-known proinflammatory cytokine and functions as an angiogenic mediator in inflammation. To our knowledge, this is the first report on an association between Erdr1 and an inflammatory skin disease. Objectives: To investigate the expression of Erdr1 in rosacea and the effect of rErdr1 on rosacea-like skin lesions induced by LL-37 in mouse. Methods: An immunohistochemical staining of Erdr1 was performed in 5 normal subjects and 11 rosacea patients to compare the expression level of Erdr1 between rosacea and the normal skin. To determine the influence of Erdr1 on rosacea, a rosacea-like BALB/c mouse model induced by LL-37 was used. Balb/c mice were intradermally injected with cathelicidin peptide LL-37 (40 μl, 320 μM) four times every 12 hours. Immunohistochemical analysis was performed for CD4, CD8, CD34 and vascular endothelial growth factor (VEGF). Results: We found that epidermal Erdr1 expression was significantly lower in rosacea patients than in normal controls. LL-37 injection induced typical rosacea features, including erythema, telangiectasia, and inflammation. The treatment with rErdr1 resulted in a significant reduction of erythema, inflammatory cell infiltration, including CD4+ and CD8+ T cells and microvessel density with VEGF. Conclusion: These results suggest that rErdr1 has the potential for the treatment of rosacea.
Jung Ha Kyung,Kim Jin Young,Lee Mu Sook,Lee Ji Yeon,Park Jae Seok,Hyun Miri,Kim Hyun Ah,Kwon Yong Shik,Choi Sang-Woong,Moon Sung Min,Suh Young Joo 대한영상의학회 2020 Korean Journal of Radiology Vol.21 No.11
Objective: We investigated the prevalence of pneumonia in novel coronavirus disease 2019 (COVID-19) patients using chest radiographs to identify the characteristics of those with initially negative chest radiographs, who were positive for pneumonia on follow-up. Materials and Methods: Retrospective cohort data of 236 COVID-19 patients were reviewed. Chest radiography was performed on admission, with serial radiographs obtained until discharge. The ‘positive conversion group’ was defined as patients whose initial chest radiographs were negative but were positive for pneumonia during follow-up. Patients with initially positive chest radiographs were defined as the ‘initial pneumonia group.’ Patients with negative initial and follow-up chest radiographs were defined as the ‘non-pneumonia group.’ Clinical and laboratory findings were compared between groups, and predictors of positive conversion were investigated. Results: Among 236 patients, 108 (45.8%) were in the non-pneumonia group, 69 (29.2%) were in the initial pneumonia group, and 59 (25%) were in the positive conversion group. The patients in the ‘initial pneumonia group’ and ‘positive conversion group’ were older, had higher C-reactive protein (CRP) and lactate dehydrogenase levels, and lower absolute lymphocyte counts than those in the ‘non-pneumonia group’ (all p < 0.001). Among patients with negative initial chest radiographs, age ≥ 45 years (odds ratio [OR]: 3.93, 95% confidence interval [CI]: 1.76–8.75, p = 0.001), absolute lymphocyte count < 1500 cells/μL (OR: 2.25, 95% CI: 1.03–4.89, p = 0.041), and CRP > 0.5 mg/dL (OR: 3.91, 95% CI: 1.54–9.91, p = 0.004) were independent predictors for future development of pneumonia. Conclusion: More than a half of COVID-19 patients initially had normal chest radiographs; however, elderly patients (≥ 45 years of age) with abnormal laboratory findings (elevated CRP and low absolute lymphocyte counts) developed pneumonia on follow-up radiographs.