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Min-JungKim,Kyo-YoungLee,Kyung-HeeMin,이명석,Choong-IllCheon,EunsookSong 한국유전학회 2003 Genes & Genomics Vol.25 No.2
In vitro t r a n s l a t i o n o f c y t o c h r o m e c o x i d a s e o n m i t o c h o n d r i a o f m o u s e tissues was compared with the level of mitochondrial DNA (mtDNA) deletion and of the transcript during aging. Translation activity of mitochondria from old testis declined considerably compared with old brain and liver. In the region of 12S rRNA and URF6L spanning COXI gene locus, age-related mtDNA deletion was considerable and multiple ranging from 7.4 kb to 9.17 kb deletion in old brain and testis, but barely detectable in old liver. The transcript amount of subunit I of cytochrome c oxidase decreased substantially in old testis, while being little reduced in brain and liver. Deletion, transcription and translation levels semed to be related to testis during aging but not in brain. Especially deletion level was not related with age in brain and liver. Present observation from testis suggests that, among the gene mutation and gene expresion steps, translational alteration may play a major role in irreversible aging process.Key words : translation, deletion, cytochrome c oxidase, aging, mouse testis mitochondria.Expression and Phylogenetic Analysis of Human Endogenous Retrovirus HERV-W env Family in Brain Tissues Kyung-Won Hong1+, Joo-Mi Yi1+, Kyung-Mi Shin1, Tae-Hyung Kim2, Jae-Won Huh1, Young-Choon Le3, Won-Ho Le1, Timothy J. Crow4 and Heui-So Kim1*1Division of Biological Sciences, College of Natural Sciences, Pusan National University, Pusan 609-735, Korea2Interdisciplinary Program of Bioinformatics, Pusan National University, Pusan 609-735, Korea
A Method and Tool for Identifying Domain Components Using Object Usage Information
이우진,권오천,Min-JungKim,Gyu-SangShin 한국전자통신연구원 2003 ETRI Journal Vol.25 No.2
To enhance the productivity of software development and accelerate time to market, software developers have recently paid more attention to a component-based development (CBD) approach due to the benefits of component reuse. Among CBD processes, the identification of reusable components is a key but difficult process. Currently, component identification depends mainly on the intuition and experience of domain experts. In addition, there are few systematic methods or tools for component identification that enable domain experts to identify reusable components. This paper presents a systematic method and its tool called a component identifier that identifies software components by using object-oriented domain information, namely, use case models, domain object models, and sequence diagrams. To illustrate our method, we use the component identifier to identify candidates of reusable components from the object-oriented domain models of a banking system. The component identifier enables domain experts to easily identify reusable components by assisting and automating identification processes in an earlier development phase.
S-50 Tumor staging of gastric cancer by endoscopic ultrasonography compared with CT
( Jung Kim ),( Sang Gyun Kim ),( Seung Jun Han ),( Jae Yong Park ),( Sooyeon Oh ),( Hyun Chae Jung ),( Ji Min Choi ),( Joo Hyun Lim ) 대한내과학회 2016 대한내과학회 추계학술대회 Vol.2016 No.1
Background:?Endoscopic ultrasonography (EUS) is useful for predicting the invasion depth of gastric cancer. We evaluated the accuracy of EUS compared with computerized tomography (CT) in gastric cancer.?Methods:?The patients who were diagnosed as gastric cancer and underwent EUS and CT from September 2005 to February 2016 were retrospectively reviewed. The staging of depth of tumor invasion (T staging) and detection of lymph node enlargement (N staging) by EUS and CT were compared with the pathological staging after endoscopic or surgical resection. Results:?A total of 4850 patients were finally analyzed. The overall accuracy of T staging by EUS was 51.7%; 59.6% in early gastric cancer, and 28.9% in advanced gastric cancer. When T1a and T1b were combined as T1, the accuracy of T staging by EUS and CT was 76.7% and 70.2%, respectively (p<0.001). The accuracy of N staging by EUS and CT was 78.7% and 81.4%, respectively (p<0.001). In multivariate analysis, the accuracy of T staging by EUS was significantly decreased by presence of ulcer, large tumor size, and advanced stage.?Conclusions:?EUS was superior to CT in T staging of gastric cancer. Presence of ulcer, large tumor size, and advanced stage were associated with decreased accuracy in T staging.