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North, Colin M,Kim, Byung-Sam,Snyder, Neil,Crawford, Robert B,Holsapple, Michael P,Kaminski, Norbert E Academic Press 2009 TOXICOLOGICAL SCIENCES Vol.107 No.1
<P>Suppression of humoral immune responses by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) has been well established to require the aryl hydrocarbon receptor; however, the downstream mechanisms for this immunotoxic response remain poorly understood. Based on evidence demonstrating that primary hepatocytes pretreated with interferon-gamma (IFN-gamma) exhibited decreased induction of cytochrome P450 1A1 (CYP1A1) by TCDD, and that serum factors alter the sensitivity of the in vitro T-cell-dependent IgM antibody forming cell (AFC) response, it was hypothesized that IFN-gamma attenuates suppression of humoral immune responses by TCDD. In fact, concomitant addition of IFN-gamma (100 U/ml) produced a concentration-related attenuation of TCDD-mediated suppression of the anti-sheep erythrocyte (anti-sRBC) IgM AFC response. Time-of-addition studies performed by adding 100 U/ml IFN-gamma at 0, 1, 2, 4, 12, 24, 48, and 72 h post-TCDD showed that suppression of the AFC response was prevented only when IFN-gamma was added within 2 h of TCDD treatment. mRNA levels of the IgM components, immunoglobulin kappa light chain, immunoglobulin mu heavy chain, and immunoglobulin J-chain were significantly decreased by TCDD treatment, an effect that was completely reversed by IFN-gamma (100 U/ml) cotreatment. Further studies showed that IFN-alpha, IFN-beta, and IFN-gamma significantly attenuate TCDD-induced increases in CYP1A1 mRNA levels to varying degrees, but concentrations as high as 1000 U/ml of type I IFNs did not reverse the effect of TCDD on the anti-sRBC IgM AFC response. In summary, IFN-gamma prevents TCDD-mediated suppression of the IgM AFC response in a concentration- and time-related manner by altering transcriptional effects associated with TCDD treatment.</P>
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Global Perspectives on Democracy and Public Stadium Finance
Timothy Kellison,Michael P. Sam,Sungil Hong,Kamilla Swart,Michael J. Mondell 글로벌지식마케팅경영학회 2020 Journal of Global Sport Management Vol.5 No.4
Arenas, ballparks, and stadiums built for professional sports teams or mega-events all around the world often come with large public costs. In democratic states, citizens are assumed to have a role in public policymaking, but previous research suggests the strength of this role can vary case-to-case. To examine the incidence of public stadium finance and public participation across the geopolitical landscape, a collective case study was employed and organized into regime type (i.e., full democracies, flawed democracies, hybrid regimes, authoritarian regimes). The results of the study show clear contrasts in the financing mechanisms within and between regime types. Additionally, each case-study grouping contained examples of citizen-led public participation, though the efficacy of these democratic actions is questionable. This review complements the growing literature on public policy and stadium finance by assessing public engagement in current stadium-subsidy debates around the world.
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