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Review on Bacterial Stress Topics
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간호·간병통합서비스병동 간호사의 자기효능감과 안전문화인식이 환자안전간호활동에 미치는 영향
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바움가르텐 『미학』과 비코 『신학문』에 나타난 계몽의 긴장 -미학과 문화학의 학문적 접근을 위한 시도-
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Hierarchical Peer-to-Peer Systems
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The relationships between isometric muscle strength and respiratory functions of the Turkish National Paralympic Goalball Team
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Polymer Micelles as Supports for the Production of Millimetric Polyethylene Beads
- 검색키워드
- 저자 : Michael E. Rosenfeld (검색결과 5 건)
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Song, Young-Sun,Cho, Mi-Kyung,Cho, Chung-Won,Rosenfeld, Michael E. The Korean Society of Food Science and Nutrition 2009 Journal of medicinal food Vol.12 No.1
It is documented that hyperhomocysteinemia (HHcy) is an independent risk factor for atherosclerosis, but whether elevated plasma homocysteine contributes to the progression of atherosclerosis in aged animals with hypercholesterolemia is still unknown. HHcy was induced in apolipoprotein E (ApoE) knockout mice (male, 32 weeks old) by feeding 2% methionine/low folate (1 mg/kg) diet for 20 weeks. HHcy induced by methionine feeding significantly increased oxidative stress, as measured by thiobarbituric-reactive substances in livers (P < .05) and genetic expression of Cu,Zn-superoxide dismutase, in methionine-fed animals compared with controls (P < .05). Furthermore, lipoprotein profiles were changed, in that low-density lipoprotein-cholesterol was shifted to very low-density lipoprotein in the methionine-supplemented group. However, nuclear factor ${\kappa}B$ activity, atherosclerotic lesions, hepatic glutathione level, lipid profiles, and activities of aspartate aminotransferase and alanine aminotransferase were not significantly different. These findings suggest that HHcy induced by methionine may promote disturbances in lipid peroxidation and modify lipoprotein metabolism but not contribute to the progression of atherosclerotic lesion in aged ApoE knockout mice.
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송영선,조미경,조정원,Michael E. Rosenfeld 한국식품영양과학회 2009 Journal of medicinal food Vol.12 No.1
It is documented that hyperhomocysteinemia (HHcy) is an independent risk factor for atherosclerosis, but whether elevated plasma homocysteine contributes to the progression of atherosclerosis in aged animals with hypercholesterolemia is still unknown. HHcy was induced in apolipoprotein E (ApoE) knockout mice (male, 32 weeks old) by feeding 2% methionine/low folate (1 mg/kg) diet for 20 weeks. HHcy induced by methionine feeding significantly increased oxidative stress, as measured by thiobarbituric-reactive substances in livers (P < .05) and genetic expression of Cu,Zn-superoxide dismutase, in methionine-fed animals compared with controls (P < .05). Furthermore, lipoprotein profiles were changed, in that low-density lipoprotein-cholesterol was shifted to very low-density lipoprotein in the methionine-supplemented group. However, nuclear factor κB activity, atherosclerotic lesions, hepatic glutathione level, lipid profiles, and activities of aspartate aminotransferase and alanine aminotransferase were not significantly different. These findings suggest that HHcy induced by methionine may promote disturbances in lipid peroxidation and modify lipoprotein metabolism but not contribute to the progression of atherosclerotic lesion in aged ApoE knockout mice.
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Young-Sun Song,Michael E. Rosenfeld 한국식품영양과학회 2004 Journal of medicinal food Vol.7 No.2
It is well documented that hyperhomocysteinemia (HHcy) is an independent risk factor for atherosclerosis. This study was designed to investigate whether some of atherosclerotic effects ascribed to HHcy are mediated by oxidative stress and nuclear factor kappa B (NFB) activation in peritoneal macrophages of C57BL/6 mice fed 2% methionine, low folate (1mg/kg) diet for 12 weeks. Plasma homocysteine concentration of mice fed methionine was 49 mol/L by 12 week of feeding, 5 times higher than that of controls. HHcy induced by methionine feeding significantly elevated oxidative stress, as measured by superoxide anion radical level (p<0.05) in peritoneal macrophages. Furthermore, NFB binding activities of peritoneal macrophages was higher in the methionine group than in the control group. These results suggest that HHcy induced by methionine may intensify disturbances in peroxidation and inflammatory mediator activation in peritoneal macrophages as possible mechanisms of its atherogenic role.
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Combinatorial patterns of histone acetylations and methylations in the human genome
Wang, Zhibin,Zang, Chongzhi,Rosenfeld, Jeffrey A,Schones, Dustin E,Barski, Artem,Cuddapah, Suresh,Cui, Kairong,Roh, Tae-Young,Peng, Weiqun,Zhang, Michael Q,Zhao, Keji Nature Publishing Group 2008 Nature genetics Vol.40 No.7
Histones are characterized by numerous posttranslational modifications that influence gene transcription. However, because of the lack of global distribution data in higher eukaryotic systems, the extent to which gene-specific combinatorial patterns of histone modifications exist remains to be determined. Here, we report the patterns derived from the analysis of 39 histone modifications in human CD4<SUP>+</SUP> T cells. Our data indicate that a large number of patterns are associated with promoters and enhancers. In particular, we identify a common modification module consisting of 17 modifications detected at 3,286 promoters. These modifications tend to colocalize in the genome and correlate with each other at an individual nucleosome level. Genes associated with this module tend to have higher expression, and addition of more modifications to this module is associated with further increased expression. Our data suggest that these histone modifications may act cooperatively to prepare chromatin for transcriptional activation.
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Chung-Mu Park,Chung-Won Cho,Michael E. Rosenfeld,Young-Sun Song 한국식품영양과학회 2008 Journal of medicinal food Vol.11 No.4
The present study was designed to investigate whether hyperhomocysteinemia (HHcy) induced by methionine supplementation promotes oxidative stress and nuclear factor κB (NFκB) activation in livers of C57BL/6 mice when fed a 2% methionine and low folate (1 mg/kg) diet for 12 weeks. Plasma homocysteine concentrations of mice fed methionine were found to be 49 μmol/L by 12 weeks of feeding, which was five times higher than that of controls. HHcy induced by methionine feeding significantly increased oxidative stress, as measured by thiobarbituric acid-reactive substances (P < .05) in livers. This was further confirmed by lower levels of hepatic glutathione (P < .05) and elevated mRNA expressions of hepatic antioxidative enzymes, such as Cu,Zn-superoxide dismutase, catalase, glutathione reductase, and L-gulonolactone oxidase in methionine-fed animals (P < .05). Hepatic function of mice fed methionine seems to be normal, while hepatic triglyceride concentration was lowered by methionine feeding. NFκB nuclear binding activities of livers were higher in the methionine group than in the control group. The above results suggest that HHcy induced by methionine may promote disturbances in lipid peroxidation and antioxidant processes and be a pro-inflammatory mediator in livers of C57BL/6 mice.
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