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RISS 인기검색어
- 검색키워드
- 저자 : Mehmet Yakut (검색결과 3 건)
- 무료
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Gokhan Polat,Sitki Ozturk,Mehmet Yakut 한국전자통신연구원 2015 ETRI Journal Vol.37 No.4
The third-party FFT IP cores available in today’s markets do not provide the desired speed demands for optical communication. This study deals with the design and implementation of a 256-point Radix-4 100 Gbit/s FFT, where computational steps are reconsidered and optimized for high-speed applications, such as radar and fiber optics. Alternative methods for FFT implementation are investigated and Radix-4 is decided to be the optimal solution for our fully parallel FPGA application. The algorithms that we will implement during the development phase are to be tested on a Xilinx Virtex-6 FPGA platform. The proposed FFT core has a fully parallel architecture with a latency of nine clocks, and the target clock rate is 312.5 MHz.
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Beray Kiran,Mutlu Karkucak,Tahsin Yakut,Kemal Ozerkan,Sebnem Sag,Mehmet Ture 대한부인종양학회 2010 Journal of Gynecologic Oncology Vol.21 No.3
Objective: This work investigates the role of glutathione S-transferase M1 (GSTM1), glutathione S-transferase T1(GSTT1), and glutathione S-transferase P1 (GSTP1) enzymes and polymorphisms, which are found in phase II detoxification reactions in the development of cervical cancer. Methods: This study was conducted with 46 patients diagnosed with cervical cancer and 52 people with no cancer history. Multiplex PCR methods were used to evaluate the GSTM1 and GSTT1 gene polymorphism. However, the GSTP1 (Ile105Val) gene polymorphism was studied using a PCR-RFLP method. The patient and control groups were compared using a chi-square test with p<0.05. Results: In the patient group, statistical significance was determined for gravidity (p=0.03), parity (p=0.01), and the number of living children (p=0.01) compared to the control group. The gene frequency of GSTM1, GSTT1, and GSTP1polymorphisms was evaluated. We observed that GSTM1 and GSTT1 null genotype frequencies were 54.3% and 32.6%respectively, while GSTP1 (Ile/Val), (Ile/Ile), (Val/Val) genotype frequencies were 52%, 44%, and 4%, respectively, in the cervical cancer patients. No statistical variation was determined between the control and patient groups in terms of GSTM1, GSTT1, and GSTP1 polymorphisms (p>0.05). Conclusion: Our results demonstrate that GSTT1, GSTM1, and GSTP1 polymorphisms are not associated with cervical cancer in Turkish patients.
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Sag, Sebnem Ozemri,Gorukmez, Ozlem,Ture, Mehmet,Gorukmez, Orhan,Topak, Ali,Sahinturk, Serdar,Ocakoglu, Gokhan,Gulten, Tuna,Ali, Ridvan,Yakut, Tahsin Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.2
Background: Myeloproliferative disorders (MPDs) are clonal hematologic malignancies originating at the level of the pluripotent hematopoietic stem cell. Matrix metalloproteases (MMPs) are proteolytic enzymes that contribute to all stages of malignancy progression. Genetic variants in the MMP genes may influence the biological function of these enzymes and change their role in carcinogenesis and progression. To our knowledge, this is the first investigation of associations between the -735 C/T and -1562 C/T polymorphisms in the MMP2 and MMP9 genes, respectively, and the risk of essential thrombocytosis (ET), and polycythemia vera (PV). Materials and Methods: The case-control study included JAK2V617F mutation positive 102 ET and PV patients and 111 controls. Polymorphisms were determined by using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and electrophoresis. Results: No statistically significant differences were detected between patient (ET+PV) and control groups regarding genotype distribution for MMP2 gene-735 C/T and MMP9 gene -1562 C/T polymorphisms and C/T allele frequency (p>0.050). Statistically borderline significance was observed between PV and control groups regarding genotype distribution for the MMP9 gene -1562 C/T polymorphism (p=0.050, OR=2.26, 95%Cl=0.99-5.16). Conclusions: Consequently this study supported that CC genotype of MMP9 gene -1562 C/T polymorphism may be related with PV even if with borderline significance.
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